iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-098248

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Cullin-5

Genbank Nucleotide ID

ABGA01336850

Gene Name

CUL5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000003842.2	ENSPPYT00000004573.2	ENSPPYP00000004398.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	8.70e-204	678.8	138	624

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 155  eLslnk...laiykesFEakfleatqefykaesaeflqenevdeYlkkvearlneeeeraaryleestetk....Llevvekeliakhl 236
           +L++n    l+iy+++FE+++l++t++fy++++ ++lq+n+v++Y+k+++a+l+eee+ra ryle+++e++    L+e+++++l++++ 
   Q: 138  NLCSNPedkLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEEEKRALRYLETRRECNsveaLMECCVNALVTSFK 226
           566666677************************************************************999999************** PP
   S: 237  esllaelvallrdkktedlsrmykLlsrvlngleellkeleshikeqgkaalt..aeekekdpkkyVerllelknklqklvseaFnnda 323
           e++lae++ ++++++te+l++m++L+++v+ng+e++lk+le+hi ++g+a+++  ae++++d++kyVe+ll+l+n+++klv+eaF++d+
   Q: 227  ETILAECQGMIKRNETEKLHLMFSLMDKVPNGIEPMLKDLEEHIISAGLADMVaaAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDP 315
           ****************************************************99999******************************** PP
   S: 324  kFlkaldkafetfvnknsvlka................akspEllAryiDqlLrks..skglteeeleaqldkvllvfkyisekdvFek 394
           +Fl+a+dka++++vn+++++k+                +k+pEllA+y+D+lLrk+  sk+lt+ee+ea+l++vllv+ky+++kdvF++
   Q: 316  RFLTARDKAYKAVVNDATIFKLelplkqkgvglktqpeSKCPELLANYCDMLLRKTplSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMR 404
           ***************************************************************************************** PP
   S: 395  yYkkhLakRLlsgksasseaEesviekLkeec.gaeftskLerMfqdlkvSedlnrqFk.eekenteesesvelsvlvLsagaWptase 481
           y+k hL++RL++++sa+se+Ee+++e+L+e++ +a++++kL+rMfqd+kvSedln++Fk ++k+n+ + +++++++++L+agaW+++se
   Q: 405  YHKAHLTRRLILDISADSEIEENMVEWLREVGmPADYVNKLARMFQDIKVSEDLNQAFKeMHKNNKLALPADSVNIKILNAGAWSRSSE 493
           ***********************************************************5688888899******************** PP
   S: 482  tekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkaelkkgkyelqVstfQmavLLafnns..ekvsveelkkatelpeeeL 568
           ++ vsLP+ele++i+++eefY+++hsgRkL+W+h ++++ +++++++g+y+l+V+tfQ+avL+a+n++  ek+s+e+lk atelp++eL
   Q: 494  KVFVSLPTELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRprEKISFENLKLATELPDAEL 582
           *******************************************************************999******************* PP
   S: 569  rrtlqsLvs.sk..kqvlkkepeske...ieeedlfsvNqef 604
           rrtl+sLv+ +k  +qvl +ep+ ++   ++e++lfsvNqef
   Q: 583  RRTLWSLVAfPKlkRQVLLYEPQVNSpkdFTEGTLFSVNQEF 624
           *********999999********977778************9 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MATSNLLKNK GSLQFEDKWD FMRPIVLKLL RQESVTKQQW FDLFSDVHAV CLWDDKGPAK 60
IHQALKEDIL EFIKQAQARV LSHQDDTALL KAYIVEWRKF FTQCDILPKP FCQLEITLMG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCTCATTCT ATGCACGAGT TATTGAAGAC AGCTGTTGTG AGCATTTCAG GACAATGCAC 60
CTCCCTTAAC ACCGAGTCCG GGATTTGGGG CGGGGTGCGG GAAAACGCCA GGTCCCGCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0031466--C:Cul5-RING ubiquitin ligase complex
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002082	Ailuropoda melanoleuca	92.69	0.00e+00	1432.00
IUUC-Apl-003564	Anas platyrhynchos	93.39	0.00e+00	1432.00
IUUC-Aca-004319	Anolis carolinensis	93.33	0.00e+00	1449.00
IUUC-Ame-011742	Astyanax mexicanus	90.78	0.00e+00	1412.00
IUUC-Bta-012515	Bos taurus	93.68	0.00e+00	1407.00
IUUC-Cel-018522	Caenorhabditis elegans	48.64	0.00e+00	694.00
IUUC-Cja-018785	Callithrix jacchus	93.72	0.00e+00	1450.00
IUUC-Cfa-020932	Canis familiaris	93.54	0.00e+00	1405.00
IUUC-Cpo-022317	Cavia porcellus	93.59	0.00e+00	1449.00
IUUC-Csa-023949	Chlorocebus sabaeus	93.85	0.00e+00	1452.00
IUUC-Cho-024570	Choloepus hoffmanni	77.21	1.00e-91	330.00
IUUC-Cin-025540	Ciona intestinalis	73.02	9.00e-152	529.00
IUUC-Csv-025978	Ciona savignyi	61.80	0.00e+00	933.00
IUUC-Dre-027958	Danio rerio	90.77	0.00e+00	1425.00
IUUC-Dno-029195	Dasypus novemcinctus	93.56	0.00e+00	1440.00
IUUC-Dor-030573	Dipodomys ordii	87.25	2.00e-173	602.00
IUUC-Dme-032083	Drosophila melanogaster	67.78	0.00e+00	833.00
IUUC-Ete-032428	Echinops telfairi	87.23	0.00e+00	999.00
IUUC-Eca-033232	Equus caballus	93.72	0.00e+00	1449.00
IUUC-Eeu-035348	Erinaceus europaeus	100.00	0.00e+00	756.00
IUUC-Fca-035401	Felis catus	93.16	0.00e+00	1412.00
IUUC-Fal-037514	Ficedula albicollis	93.26	0.00e+00	1429.00
IUUC-Gmo-038577	Gadus morhua	88.12	0.00e+00	1380.00
IUUC-Gga-041096	Gallus gallus	93.16	0.00e+00	1432.00
IUUC-Gac-042108	Gasterosteus aculeatus	88.89	0.00e+00	1390.00
IUUC-Ggo-045313	Gorilla gorilla	93.33	0.00e+00	1444.00
IUUC-Hsa-045974	Homo sapiens	93.85	0.00e+00	1452.00
IUUC-Itr-049009	Ictidomys tridecemlineatus	93.85	0.00e+00	1450.00
IUUC-Lch-050615	Latimeria chalumnae	92.75	0.00e+00	1395.00
IUUC-Loc-051807	Lepisosteus oculatus	92.18	0.00e+00	1427.00
IUUC-Laf-053601	Loxodonta africana	93.68	0.00e+00	1438.00
IUUC-Mcc-055260	Macaca mulatta	93.85	0.00e+00	1450.00
IUUC-Meu-056632	Macropus eugenii	89.60	0.00e+00	837.00
IUUC-Mga-059658	Meleagris gallopavo	93.17	0.00e+00	1437.00
IUUC-Mmr-061424	Microcebus murinus	83.57	0.00e+00	1238.00
IUUC-Mdo-061836	Monodelphis domestica	93.46	0.00e+00	1446.00
IUUC-Mmu-063757	Mus musculus	92.31	0.00e+00	1431.00
IUUC-Mpu-065823	Mustela putorius furo	93.59	0.00e+00	1450.00
IUUC-Mlu-066969	Myotis lucifugus	93.29	0.00e+00	1432.00
IUUC-Nle-069943	Nomascus leucogenys	93.85	0.00e+00	1452.00
IUUC-Opr-070820	Ochotona princeps	88.99	0.00e+00	747.00
IUUC-Ont-071599	Oreochromis niloticus	90.26	0.00e+00	1409.00
IUUC-Oan-072743	Ornithorhynchus anatinus	93.28	0.00e+00	1404.00
IUUC-Ocu-074586	Oryctolagus cuniculus	93.85	0.00e+00	1452.00
IUUC-Ola-087526	Oryzias latipes	90.00	0.00e+00	1408.00
IUUC-Oga-088425	Otolemur garnettii	89.18	0.00e+00	1398.00
IUUC-Oar-089785	Ovis aries	93.85	0.00e+00	1452.00
IUUC-Ptr-091242	Pan troglodytes	93.85	0.00e+00	1452.00
IUUC-Pan-092246	Papio anubis	93.85	0.00e+00	1452.00
IUUC-Psi-094081	Pelodiscus sinensis	93.41	0.00e+00	1437.00
IUUC-Pma-094735	Petromyzon marinus	72.58	0.00e+00	640.00
IUUC-Pfo-097305	Poecilia formosa	89.88	0.00e+00	1400.00
IUUC-Pca-100756	Procavia capensis	88.27	0.00e+00	875.00
IUUC-Pva-102990	Pteropus vampyrus	76.88	0.00e+00	797.00
IUUC-Rno-105887	Rattus norvegicus	92.56	0.00e+00	1433.00
IUUC-Sha-107016	Sarcophilus harrisii	93.46	0.00e+00	1446.00
IUUC-Sar-113558	Sorex araneus	87.95	0.00e+00	1365.00
IUUC-Ssc-115414	Sus scrofa	93.85	0.00e+00	1452.00
IUUC-Tgu-116801	Taeniopygia guttata	92.44	0.00e+00	1423.00
IUUC-Tru-117565	Takifugu rubripes	90.13	0.00e+00	1409.00
IUUC-Tsy-119292	Tarsius syrichta	96.44	0.00e+00	1352.00
IUUC-Tni-120471	Tetraodon nigroviridis	90.01	0.00e+00	1408.00
IUUC-Tbe-127838	Tupaia belangeri	88.08	0.00e+00	1382.00
IUUC-Ttr-128345	Tursiops truncatus	93.33	0.00e+00	1444.00
IUUC-Vpa-130191	Vicugna pacos	80.87	0.00e+00	733.00
IUUC-Xtr-132810	Xenopus tropicalis	92.69	0.00e+00	1437.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence