iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091242

UUCD1 version

UUC-PaT-00191

Ensembl Protein ID

ENSPTRP00000007307.4

UniProt Accession

H2Q4P8; H2Q4P8_PANTR

Genbank Protein ID

JAA07997.1; JAA16943.1; JAA26813.1; JAA35851.1

Protein Name

Cullin 5

Genbank Nucleotide ID

AACZ03080390; GABF01005202; GABD01006287; GABE01008888

Gene Name

CUL5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000004246.5	ENSPTRT00000007919.4	ENSPTRP00000007307.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	1.60e-230	767.0	22	672

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 2    lreavkkilrqesv.kkeyeelytavynlclsk..vgaklYkklkevleefikqvkkkveesedeq.lLktynreWekfreqlkvlrki 86
           +r +v k+lrqesv k+++ +l+++v+++cl++  + ak++++lke++ efikq++++v +++d++ lLk+y++eW+kf++q+++l+k+
   Q: 22   MRPIVLKLLRQESVtKQQWFDLFSDVHAVCLWDdkGPAKIHQALKEDILEFIKQAQARVLSHQDDTaLLKAYIVEWRKFFTQCDILPKP 110
           7899****************************9999***************************************************** PP
   S: 87   fayldrtyvkk.....skkv..sevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveLslnk...laiyk 165
           f++l+ t ++k     +++v  s vrkL+ld+w+++i+++ik+rl+++++kl++aeR gea+d++l+ gv+es+v+L++n    l+iy+
   Q: 111  FCQLEITLMGKqgsnkKSNVedSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGVRESYVNLCSNPedkLQIYR 199
           ***********8765544448899*******************************************************99999***** PP
   S: 166  esFEakfleatqefykaesaeflqenevdeYlkkvearlneeeeraaryleestetk....Llevvekeliakhlesllaelvallrdk 250
           ++FE+++l++t++fy++++ ++lq+n+v++Y+k+++a+l+eee+ra ryle+++e++    L+e+++++l++++ e++lae++ +++++
   Q: 200  DNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEEEKRALRYLETRRECNsveaLMECCVNALVTSFKETILAECQGMIKRN 288
           *******************************************************999999**************************** PP
   S: 251  ktedlsrmykLlsrvlngleellkeleshikeqgkaalt..aeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfv 337
           +te+l++m++L+++v+ng+e++lk+le+hi ++g+a+++  ae++++d++kyVe+ll+l+n+++klv+eaF++d++Fl+a+dka++++v
   Q: 289  ETEKLHLMFSLMDKVPNGIEPMLKDLEEHIISAGLADMVaaAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVV 377
           **************************************99999********************************************** PP
   S: 338  nknsvlka................akspEllAryiDqlLrks..skglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgk 408
           n+++++k+                +k+pEllA+y+D+lLrk+  sk+lt+ee+ea+l++vllv+ky+++kdvF++y+k hL++RL++++
   Q: 378  NDATIFKLelplkqkgvglktqpeSKCPELLANYCDMLLRKTplSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDI 466
           ***************************************************************************************** PP
   S: 409  sasseaEesviekLkeec.gaeftskLerMfqdlkvSedlnrqFk.eekenteesesvelsvlvLsagaWptasetekvsLPaelekti 495
           sa+se+Ee+++e+L+e++ +a++++kL+rMfqd+kvSedln++Fk ++k+n+ + +++++++++L+agaW+++se++ vsLP+ele++i
   Q: 467  SADSEIEENMVEWLREVGmPADYVNKLARMFQDIKVSEDLNQAFKeMHKNNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLI 555
           *********************************************5688888899********************************** PP
   S: 496  ekfeefYlekhsgRkLqWqhtlgraelkaelkkgkyelqVstfQmavLLafnns..ekvsveelkkatelpeeeLrrtlqsLvs.sk.. 579
           +++eefY+++hsgRkL+W+h ++++ +++++++g+y+l+V+tfQ+avL+a+n++  ek+s+e+lk atelp++eLrrtl+sLv+ +k  
   Q: 556  PEVEEFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRprEKISFENLKLATELPDAELRRTLWSLVAfPKlk 644
           *****************************************************999****************************99999 PP
   S: 580  kqvlkkepeske...ieeedlfsvNqef 604
           +qvl +ep+ ++   ++e++lfsvNqef
   Q: 645  RQVLLYEPQVNSpkdFTEGTLFSVNQEF 672
           9********977778************9 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MATSNLLKNK GSLQFEDKWD FMRPIVLKLL RQESVTKQQW FDLFSDVHAV CLWDDKGPAK 60
IHQALKEDIL EFIKQAQARV LSHQDDTALL KAYIVEWRKF FTQCDILPKP FCQLEITLMG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAGTCAACA CATATTTACT GGGCGCATTC TATGCACGAG TTATTGAAGA CAGCTGTTGT 60
GAGCATTTCA GGACAATGCA CCTCCCTTAA CACCGAGTCC GGGATTTGGG GCGGGGTGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0031466--C:Cul5-RING ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002082	Ailuropoda melanoleuca	98.85	0.00e+00	1553.00
IUUC-Apl-003564	Anas platyrhynchos	99.61	0.00e+00	1553.00
IUUC-Aca-004319	Anolis carolinensis	99.36	0.00e+00	1566.00
IUUC-Ame-011742	Astyanax mexicanus	96.93	0.00e+00	1531.00
IUUC-Bta-012515	Bos taurus	100.00	0.00e+00	1529.00
IUUC-Cel-018522	Caenorhabditis elegans	51.35	0.00e+00	756.00
IUUC-Cja-018785	Callithrix jacchus	99.87	0.00e+00	1570.00
IUUC-Cfa-020932	Canis familiaris	99.87	0.00e+00	1527.00
IUUC-Cpo-022317	Cavia porcellus	99.74	0.00e+00	1570.00
IUUC-Csa-023949	Chlorocebus sabaeus	100.00	0.00e+00	1573.00
IUUC-Cho-024570	Choloepus hoffmanni	99.53	1.00e-127	449.00
IUUC-Cin-025540	Ciona intestinalis	73.02	8.00e-152	529.00
IUUC-Csv-025978	Ciona savignyi	65.06	0.00e+00	1008.00
IUUC-Dre-027958	Danio rerio	96.92	0.00e+00	1546.00
IUUC-Dno-029195	Dasypus novemcinctus	99.74	0.00e+00	1561.00
IUUC-Dor-030573	Dipodomys ordii	87.25	2.00e-173	602.00
IUUC-Dme-032083	Drosophila melanogaster	68.13	0.00e+00	921.00
IUUC-Ete-032428	Echinops telfairi	82.69	0.00e+00	1237.00
IUUC-Eca-033232	Equus caballus	99.87	0.00e+00	1570.00
IUUC-Eeu-035348	Erinaceus europaeus	100.00	0.00e+00	756.00
IUUC-Fca-035401	Felis catus	99.35	0.00e+00	1534.00
IUUC-Fal-037514	Ficedula albicollis	99.48	0.00e+00	1551.00
IUUC-Gmo-038577	Gadus morhua	94.13	0.00e+00	1495.00
IUUC-Gga-041096	Gallus gallus	99.35	0.00e+00	1554.00
IUUC-Gac-042108	Gasterosteus aculeatus	95.02	0.00e+00	1508.00
IUUC-Ggo-045313	Gorilla gorilla	99.49	0.00e+00	1565.00
IUUC-Hsa-045974	Homo sapiens	100.00	0.00e+00	1573.00
IUUC-Itr-049009	Ictidomys tridecemlineatus	100.00	0.00e+00	1569.00
IUUC-Lch-050615	Latimeria chalumnae	99.08	0.00e+00	1516.00
IUUC-Loc-051807	Lepisosteus oculatus	98.33	0.00e+00	1548.00
IUUC-Laf-053601	Loxodonta africana	99.87	0.00e+00	1560.00
IUUC-Mcc-055260	Macaca mulatta	100.00	0.00e+00	1571.00
IUUC-Meu-056632	Macropus eugenii	99.58	0.00e+00	958.00
IUUC-Mga-059658	Meleagris gallopavo	99.36	0.00e+00	1553.00
IUUC-Mmr-061424	Microcebus murinus	89.73	0.00e+00	1359.00
IUUC-Mdo-061836	Monodelphis domestica	99.62	0.00e+00	1567.00
IUUC-Mmu-063757	Mus musculus	98.46	0.00e+00	1552.00
IUUC-Mpu-065823	Mustela putorius furo	99.74	0.00e+00	1570.00
IUUC-Mlu-066969	Myotis lucifugus	99.48	0.00e+00	1553.00
IUUC-Nle-069943	Nomascus leucogenys	100.00	0.00e+00	1573.00
IUUC-Opr-070820	Ochotona princeps	100.00	0.00e+00	868.00
IUUC-Ont-072527	Oreochromis niloticus	96.03	0.00e+00	1528.00
IUUC-Oan-072743	Ornithorhynchus anatinus	99.60	0.00e+00	1525.00
IUUC-Ocu-074586	Oryctolagus cuniculus	100.00	0.00e+00	1573.00
IUUC-Ola-087526	Oryzias latipes	96.03	0.00e+00	1527.00
IUUC-Oga-088425	Otolemur garnettii	95.36	0.00e+00	1519.00
IUUC-Oar-089785	Ovis aries	100.00	0.00e+00	1573.00
IUUC-Pan-092246	Papio anubis	100.00	0.00e+00	1573.00
IUUC-Psi-094081	Pelodiscus sinensis	99.61	0.00e+00	1558.00
IUUC-Pma-094735	Petromyzon marinus	81.80	0.00e+00	746.00
IUUC-Pfo-097305	Poecilia formosa	95.90	0.00e+00	1518.00
IUUC-Pab-098248	Pongo abelii	93.85	0.00e+00	1452.00
IUUC-Pca-100756	Procavia capensis	88.27	0.00e+00	876.00
IUUC-Pva-102990	Pteropus vampyrus	85.90	0.00e+00	919.00
IUUC-Rno-105887	Rattus norvegicus	98.72	0.00e+00	1554.00
IUUC-Sha-107016	Sarcophilus harrisii	99.62	0.00e+00	1567.00
IUUC-Sar-113558	Sorex araneus	94.17	0.00e+00	1486.00
IUUC-Ssc-115414	Sus scrofa	100.00	0.00e+00	1573.00
IUUC-Tgu-116801	Taeniopygia guttata	98.59	0.00e+00	1545.00
IUUC-Tru-117565	Takifugu rubripes	96.28	0.00e+00	1530.00
IUUC-Tsy-119292	Tarsius syrichta	94.01	0.00e+00	1375.00
IUUC-Tni-120471	Tetraodon nigroviridis	96.16	0.00e+00	1523.00
IUUC-Tbe-127838	Tupaia belangeri	94.23	0.00e+00	1502.00
IUUC-Ttr-128345	Tursiops truncatus	99.49	0.00e+00	1564.00
IUUC-Vpa-130191	Vicugna pacos	90.85	0.00e+00	855.00
IUUC-Xtr-132810	Xenopus tropicalis	98.85	0.00e+00	1558.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence