iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cpo-022337

Ensembl Protein ID

ENSCPOP00000009027.2

UniProt Accession

H0VG10; H0VG10_CAVPO

Genbank Protein ID

ENSCPOP00000009027

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02008383

Gene Name

NOD2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000010054.3	ENSCPOT00000010145.2	ENSCPOP00000009027.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/CARD	1.20e-10	41.8	141	180

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/CARD

   S: 3    eeyrlllstlqdrvrklLdvtdvldkylseflleeekeli 42
           +e+rl+++t ++r+r+lLd+++v++++l++fll+  +e +
   Q: 141  DEIRLPIFTASQRARRLLDLATVKANGLAAFLLQYIEESP 180
           8********************************8777765 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MSSQEAFQAQ RSQLVGLLVS GSLEGFESIL DWLLSWEVLS WEEYEGLRLP SQPLSHAARH 60
LLDMVWNKGS WSCQKFLEAV QEAQTDSQPP ELHDSWDSHS CHPVQDLQRH RPAIVRRLYS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGCTCAC AGGAAGCTTT CCAGGCACAG AGGAGCCAGC TGGTGGGGCT GCTTGTGTCA 60
GGGTCCTTGG AGGGCTTTGA AAGCATCCTG GACTGGCTGC TGTCCTGGGA GGTGCTCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome

Interpro

IPR001315--CARD
IPR011029--DEATH-like_dom
IPR001611--Leu-rich_rpt
IPR007111--NACHT_NTPase
IPR027417--P-loop_NTPase

PROSITE

PS50209--CARD
PS50837--NACHT

Pfam

PF00619--CARD
PF13516--LRR_6

Gene Ontology

GO:0016323--C:basolateral plasma membrane
GO:0009986--C:cell surface
GO:0008180--C:COP9 signalosome
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0031982--C:vesicle
GO:0005524--F:ATP binding
GO:0032500--F:muramyl dipeptide binding
GO:0042834--F:peptidoglycan binding
GO:0071225--P:cellular response to muramyl dipeptide
GO:0002374--P:cytokine secretion involved in immune response
GO:0042742--P:defense response to bacterium
GO:0016045--P:detection of bacterium
GO:0032498--P:detection of muramyl dipeptide
GO:0045087--P:innate immune response
GO:0030277--P:maintenance of gastrointestinal epithelium
GO:0070431--P:nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0050871--P:positive regulation of B cell activation
GO:1900017--P:positive regulation of cytokine production involved in inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050718--P:positive regulation of interleukin-1 beta secretion
GO:0032740--P:positive regulation of interleukin-17 production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0032757--P:positive regulation of interleukin-8 production
GO:0046330--P:positive regulation of JNK cascade
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1901224--P:positive regulation of NIK/NF-kappaB signaling
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032760--P:positive regulation of tumor necrosis factor production
GO:0002830--P:positive regulation of type 2 immune response
GO:0042981--P:regulation of apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001822	Ailuropoda melanoleuca	76.50	0.00e+00	1396.00
IUUC-Ame-011021	Astyanax mexicanus	45.34	0.00e+00	872.00
IUUC-Bta-013241	Bos taurus	76.60	0.00e+00	1531.00
IUUC-Cja-019633	Callithrix jacchus	76.50	0.00e+00	1174.00
IUUC-Cfa-020039	Canis familiaris	77.37	0.00e+00	1512.00
IUUC-Csa-023906	Chlorocebus sabaeus	80.08	0.00e+00	1584.00
IUUC-Dre-027568	Danio rerio	45.83	0.00e+00	816.00
IUUC-Dno-029098	Dasypus novemcinctus	76.23	0.00e+00	1413.00
IUUC-Dor-031102	Dipodomys ordii	83.65	0.00e+00	628.00
IUUC-Ete-032943	Echinops telfairi	75.94	0.00e+00	1095.00
IUUC-Eca-034310	Equus caballus	79.59	0.00e+00	1527.00
IUUC-Eeu-034589	Erinaceus europaeus	82.58	7.00e-162	564.00
IUUC-Fca-036252	Felis catus	74.40	0.00e+00	743.00
IUUC-Gac-041442	Gasterosteus aculeatus	43.94	0.00e+00	791.00
IUUC-Ggo-044861	Gorilla gorilla	80.17	0.00e+00	1539.00
IUUC-Hsa-046093	Homo sapiens	79.98	0.00e+00	1539.00
IUUC-Itr-048543	Ictidomys tridecemlineatus	79.17	0.00e+00	1451.00
IUUC-Lch-049454	Latimeria chalumnae	52.38	0.00e+00	903.00
IUUC-Laf-053553	Loxodonta africana	78.34	0.00e+00	1421.00
IUUC-Mcc-055772	Macaca mulatta	80.46	0.00e+00	1568.00
IUUC-Meu-056785	Macropus eugenii	48.38	2.00e-112	400.00
IUUC-Mmr-060596	Microcebus murinus	78.63	0.00e+00	1501.00
IUUC-Mdo-062983	Monodelphis domestica	64.70	0.00e+00	1076.00
IUUC-Mmu-063951	Mus musculus	77.37	0.00e+00	1513.00
IUUC-Mpu-066412	Mustela putorius furo	77.47	0.00e+00	1522.00
IUUC-Mlu-067601	Myotis lucifugus	76.38	0.00e+00	1387.00
IUUC-Nle-069913	Nomascus leucogenys	80.43	0.00e+00	1307.00
IUUC-Opr-070999	Ochotona princeps	78.40	0.00e+00	943.00
IUUC-Ont-072512	Oreochromis niloticus	44.90	0.00e+00	846.00
IUUC-Oan-073564	Ornithorhynchus anatinus	59.46	0.00e+00	1065.00
IUUC-Ocu-074837	Oryctolagus cuniculus	81.62	0.00e+00	1538.00
IUUC-Ola-086555	Oryzias latipes	44.14	0.00e+00	795.00
IUUC-Oga-088909	Otolemur garnettii	77.66	0.00e+00	1477.00
IUUC-Oar-089315	Ovis aries	75.56	0.00e+00	1468.00
IUUC-Ptr-090542	Pan troglodytes	80.17	0.00e+00	1538.00
IUUC-Pan-092545	Papio anubis	80.27	0.00e+00	1561.00
IUUC-Pma-094167	Petromyzon marinus	33.97	3.00e-64	239.00
IUUC-Ppa-095344	Physcomitrella patens	25.56	3.00e-05	44.30
IUUC-Pfo-096976	Poecilia formosa	43.98	0.00e+00	818.00
IUUC-Pab-098481	Pongo abelii	79.59	0.00e+00	1524.00
IUUC-Pca-100135	Procavia capensis	78.41	0.00e+00	1113.00
IUUC-Pva-102127	Pteropus vampyrus	76.69	0.00e+00	1370.00
IUUC-Rno-105783	Rattus norvegicus	77.08	0.00e+00	1481.00
IUUC-Sar-113448	Sorex araneus	70.36	0.00e+00	877.00
IUUC-Tru-118708	Takifugu rubripes	43.44	0.00e+00	771.00
IUUC-Tni-120172	Tetraodon nigroviridis	36.12	4.00e-32	131.00
IUUC-Tbe-127661	Tupaia belangeri	82.58	0.00e+00	808.00
IUUC-Ttr-128318	Tursiops truncatus	72.34	0.00e+00	1333.00
IUUC-Vpa-130502	Vicugna pacos	71.43	7.00e-81	295.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence