iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-036252

Ensembl Protein ID

ENSFCAP00000007886.3

UniProt Accession

M3W9P9; M3W9P9_FELCA

Genbank Protein ID

ENSFCAP00000007886

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02018766

Gene Name

NOD2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000008505.3	ENSFCAT00000008507.3	ENSFCAP00000007886.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/CARD	1.80e-13	50.8	169	225

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/CARD

   S: 3    eeyrlllstlqdrvrklLdvtdvldkylseflleeekelilaaaetkgnmqaaelLLk 60
           +e+rl+++t ++r+r+lLd+++v++++l++fll +++el+++ a + g++++  + ++
   Q: 169  DEIRLPVFTSSQRARRLLDLATVKANGLAAFLLRHVQELPVPVALPFGDAACE-KYMS 225
           8*************************************************998.5555 PP

Organism

Felis catus

Protein Sequence
(Fasta)

KGREGLGAVG KEAVRSPVLI SLSFPGYEMC TQEALQAQRS QLVGLLVSGS LEGFESILDW 60
LLSWEVLSWE DYEGLSLLGQ PLSQLARRLL DTVWKKGAWG CEQLIAAVRE AQTGCQAPEL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGGGAAGGG AGGGCCTGGG GGCAGTTGGG AAGGAGGCGG TGGTAAGTGG GGTCCGTGCT 60
CTCCTAGGCT TTGAAATGAC TTAGTTTGCG CTATGATTTT TACTTCACCT GGGGCTAAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome

Interpro

IPR001315--CARD
IPR011029--DEATH-like_dom
IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR007111--NACHT_NTPase
IPR027417--P-loop_NTPase

PROSITE

PS50209--CARD
PS51450--LRR
PS50837--NACHT

Pfam

PF00619--CARD
PF13516--LRR_6

Gene Ontology

GO:0016323--C:basolateral plasma membrane
GO:0009986--C:cell surface
GO:0008180--C:COP9 signalosome
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0031982--C:vesicle
GO:0005524--F:ATP binding
GO:0032500--F:muramyl dipeptide binding
GO:0042834--F:peptidoglycan binding
GO:0071225--P:cellular response to muramyl dipeptide
GO:0002374--P:cytokine secretion involved in immune response
GO:0042742--P:defense response to bacterium
GO:0016045--P:detection of bacterium
GO:0032498--P:detection of muramyl dipeptide
GO:0045087--P:innate immune response
GO:0030277--P:maintenance of gastrointestinal epithelium
GO:0070431--P:nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0050871--P:positive regulation of B cell activation
GO:1900017--P:positive regulation of cytokine production involved in inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050718--P:positive regulation of interleukin-1 beta secretion
GO:0032740--P:positive regulation of interleukin-17 production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0032757--P:positive regulation of interleukin-8 production
GO:0046330--P:positive regulation of JNK cascade
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1901224--P:positive regulation of NIK/NF-kappaB signaling
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032760--P:positive regulation of tumor necrosis factor production
GO:0002830--P:positive regulation of type 2 immune response
GO:0042981--P:regulation of apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001822	Ailuropoda melanoleuca	82.54	0.00e+00	812.00
IUUC-Ame-011021	Astyanax mexicanus	38.60	4.00e-178	618.00
IUUC-Bta-013241	Bos taurus	80.18	0.00e+00	860.00
IUUC-Cja-019633	Callithrix jacchus	78.09	0.00e+00	808.00
IUUC-Cfa-020039	Canis familiaris	86.61	0.00e+00	899.00
IUUC-Cpo-022337	Cavia porcellus	74.40	0.00e+00	794.00
IUUC-Csa-023906	Chlorocebus sabaeus	79.03	0.00e+00	845.00
IUUC-Dre-027568	Danio rerio	35.70	8.00e-134	471.00
IUUC-Dno-029098	Dasypus novemcinctus	79.75	0.00e+00	723.00
IUUC-Dor-031102	Dipodomys ordii	73.09	0.00e+00	676.00
IUUC-Ete-032943	Echinops telfairi	77.17	2.00e-149	523.00
IUUC-Eca-034310	Equus caballus	85.89	0.00e+00	862.00
IUUC-Eeu-034589	Erinaceus europaeus	86.19	4.00e-169	588.00
IUUC-Gac-041442	Gasterosteus aculeatus	43.22	2.00e-125	443.00
IUUC-Ggo-044861	Gorilla gorilla	79.39	0.00e+00	839.00
IUUC-Hsa-046093	Homo sapiens	79.22	0.00e+00	837.00
IUUC-Itr-048543	Ictidomys tridecemlineatus	79.68	0.00e+00	815.00
IUUC-Lch-049454	Latimeria chalumnae	62.02	1.00e-128	454.00
IUUC-Laf-053553	Loxodonta africana	78.40	0.00e+00	786.00
IUUC-Mcc-055772	Macaca mulatta	80.46	0.00e+00	823.00
IUUC-Meu-056785	Macropus eugenii	67.38	1.00e-112	401.00
IUUC-Mmr-060596	Microcebus murinus	80.58	0.00e+00	828.00
IUUC-Mdo-062983	Monodelphis domestica	72.70	5.00e-150	525.00
IUUC-Mmu-063951	Mus musculus	72.85	0.00e+00	781.00
IUUC-Mpu-066412	Mustela putorius furo	84.01	0.00e+00	878.00
IUUC-Mlu-067601	Myotis lucifugus	80.67	0.00e+00	738.00
IUUC-Nle-069913	Nomascus leucogenys	86.76	1.00e-178	620.00
IUUC-Opr-070999	Ochotona princeps	77.26	3.00e-153	535.00
IUUC-Ont-072512	Oreochromis niloticus	37.20	2.00e-164	572.00
IUUC-Oan-073564	Ornithorhynchus anatinus	61.52	5.00e-172	598.00
IUUC-Ocu-074837	Oryctolagus cuniculus	82.27	0.00e+00	863.00
IUUC-Ola-086555	Oryzias latipes	43.39	4.00e-114	405.00
IUUC-Oga-088909	Otolemur garnettii	81.18	0.00e+00	870.00
IUUC-Oar-089315	Ovis aries	80.04	0.00e+00	848.00
IUUC-Ptr-090542	Pan troglodytes	79.22	0.00e+00	837.00
IUUC-Pan-092545	Papio anubis	78.53	0.00e+00	823.00
IUUC-Pma-094167	Petromyzon marinus	33.17	3.00e-47	182.00
IUUC-Ppa-095344	Physcomitrella patens	25.36	2.00e-07	51.20
IUUC-Pfo-096976	Poecilia formosa	41.99	1.00e-116	414.00
IUUC-Pab-098481	Pongo abelii	79.05	0.00e+00	833.00
IUUC-Pca-100135	Procavia capensis	71.30	0.00e+00	639.00
IUUC-Pva-102127	Pteropus vampyrus	75.60	0.00e+00	731.00
IUUC-Rno-105783	Rattus norvegicus	75.18	0.00e+00	802.00
IUUC-Sce-106163	Saccharomyces cerevisiae	25.00	3.20e-02	34.70
IUUC-Sar-113448	Sorex araneus	77.89	0.00e+00	824.00
IUUC-Tru-118708	Takifugu rubripes	42.29	4.00e-107	382.00
IUUC-Tni-120172	Tetraodon nigroviridis	34.87	2.00e-30	125.00
IUUC-Tbe-127661	Tupaia belangeri	85.60	2.00e-174	606.00
IUUC-Ttr-128318	Tursiops truncatus	73.16	0.00e+00	735.00
IUUC-Vpa-130502	Vicugna pacos	74.74	2.00e-155	543.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence