iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Rno-105783

Ensembl Protein ID

ENSRNOP00000073236.1

UniProt Accession

A0A0G2K4Z7; A0A0G2K4Z7_RAT

Genbank Protein ID

ENSRNOP00000073236

Protein Name

Nucleotide-binding oligomerization domain-containing 2

Genbank Nucleotide ID

AABR07043075

Gene Name

Nod2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000014124.7	ENSRNOT00000080964.1	ENSRNOP00000073236.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC	RAID2
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/CARD	1.80e-12	48.0	141	194

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/CARD

   S: 3    eeyrlllstlqdrvrklLdvtdvldkylseflleeekelilaaaetkgnmqaael 57
           ee+rl+++t ++r+r+lLd++ v++++l++fll+++ +l++    + +++++  +
   Q: 141  EEIRLPIFTSSQRARRLLDLAAVKANGLAAFLLQHVRKLPASLSLPYEAAECQ-K 194
           8*****************************************99999999998.4 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MCSQEDFQAQ RSQLVALLVS GSLEGFESIL DWLLSWDVLS REDYEGLSLP GQPLSHSARR 60
LLDTVCNKGV WGCQKLFEAV QEAQANSHTF ELQGCWDVHS LHPTRDLQSH RPAIVRRLCS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAATGAGTAG CATACCAGTG GGCTCTGAAC CAACTTTGTG TGCACTATGA CATCCCATTT 60
TTGCTGGAAT TGGCATCTTT ACAGTAAGCC CCAGCTCTAC TCATGGAGCA GTAAGTAGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome

Interpro

IPR007109--Brix
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR001611--Leu-rich_rpt
IPR007111--NACHT_NTPase
IPR027417--P-loop_NTPase

PROSITE

PS50209--CARD
PS50837--NACHT

Pfam

PF00619--CARD
PF13516--LRR_6

Gene Ontology

GO:0016323--C:basolateral plasma membrane
GO:0009986--C:cell surface
GO:0008180--C:COP9 signalosome
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0031982--C:vesicle
GO:0005524--F:ATP binding
GO:0032500--F:muramyl dipeptide binding
GO:0042834--F:peptidoglycan binding
GO:0071225--P:cellular response to muramyl dipeptide
GO:0071407--P:cellular response to organic cyclic compound
GO:0002374--P:cytokine secretion involved in immune response
GO:0042742--P:defense response to bacterium
GO:0016045--P:detection of bacterium
GO:0032498--P:detection of muramyl dipeptide
GO:0045087--P:innate immune response
GO:0030277--P:maintenance of gastrointestinal epithelium
GO:0070431--P:nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0050871--P:positive regulation of B cell activation
GO:0008284--P:positive regulation of cell proliferation
GO:1900017--P:positive regulation of cytokine production involved in inflammatory response
GO:0002732--P:positive regulation of dendritic cell cytokine production
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050718--P:positive regulation of interleukin-1 beta secretion
GO:0032740--P:positive regulation of interleukin-17 production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0032757--P:positive regulation of interleukin-8 production
GO:0046330--P:positive regulation of JNK cascade
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1901224--P:positive regulation of NIK/NF-kappaB signaling
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032760--P:positive regulation of tumor necrosis factor production
GO:0002830--P:positive regulation of type 2 immune response
GO:0042981--P:regulation of apoptotic process
GO:0032495--P:response to muramyl dipeptide
GO:0007584--P:response to nutrient

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001822	Ailuropoda melanoleuca	77.07	0.00e+00	1342.00
IUUC-Ame-011021	Astyanax mexicanus	46.49	0.00e+00	864.00
IUUC-Bta-013241	Bos taurus	76.16	0.00e+00	1450.00
IUUC-Cja-019633	Callithrix jacchus	77.11	0.00e+00	1138.00
IUUC-Cfa-020039	Canis familiaris	76.36	0.00e+00	1436.00
IUUC-Cpo-022337	Cavia porcellus	77.08	0.00e+00	1410.00
IUUC-Csa-023906	Chlorocebus sabaeus	80.00	0.00e+00	1506.00
IUUC-Dre-027568	Danio rerio	47.34	0.00e+00	842.00
IUUC-Dno-029098	Dasypus novemcinctus	75.58	0.00e+00	1323.00
IUUC-Dor-031102	Dipodomys ordii	74.57	0.00e+00	686.00
IUUC-Ete-032943	Echinops telfairi	75.26	0.00e+00	1016.00
IUUC-Eca-034310	Equus caballus	79.27	0.00e+00	1448.00
IUUC-Eeu-034589	Erinaceus europaeus	71.65	2.00e-152	533.00
IUUC-Fca-036252	Felis catus	75.18	0.00e+00	741.00
IUUC-Gac-041442	Gasterosteus aculeatus	46.27	0.00e+00	806.00
IUUC-Ggo-044861	Gorilla gorilla	80.20	0.00e+00	1460.00
IUUC-Hsa-046093	Homo sapiens	80.00	0.00e+00	1458.00
IUUC-Itr-048543	Ictidomys tridecemlineatus	78.81	0.00e+00	1419.00
IUUC-Lch-049454	Latimeria chalumnae	53.39	0.00e+00	886.00
IUUC-Laf-053553	Loxodonta africana	77.37	0.00e+00	1333.00
IUUC-Mcc-055772	Macaca mulatta	79.80	0.00e+00	1481.00
IUUC-Meu-056785	Macropus eugenii	48.71	9.00e-113	401.00
IUUC-Mmr-060596	Microcebus murinus	78.38	0.00e+00	1431.00
IUUC-Mdo-062983	Monodelphis domestica	64.76	0.00e+00	1033.00
IUUC-Mmu-063951	Mus musculus	91.50	0.00e+00	1734.00
IUUC-Mpu-066412	Mustela putorius furo	77.17	0.00e+00	1441.00
IUUC-Mlu-067601	Myotis lucifugus	75.83	0.00e+00	1310.00
IUUC-Nle-069913	Nomascus leucogenys	80.71	0.00e+00	1234.00
IUUC-Opr-070999	Ochotona princeps	77.88	0.00e+00	903.00
IUUC-Ont-072512	Oreochromis niloticus	46.39	0.00e+00	862.00
IUUC-Oan-073564	Ornithorhynchus anatinus	58.44	0.00e+00	1016.00
IUUC-Ocu-074837	Oryctolagus cuniculus	80.40	0.00e+00	1473.00
IUUC-Ola-086555	Oryzias latipes	44.98	0.00e+00	809.00
IUUC-Oga-088909	Otolemur garnettii	77.07	0.00e+00	1410.00
IUUC-Oar-089315	Ovis aries	75.76	0.00e+00	1404.00
IUUC-Ptr-090542	Pan troglodytes	80.30	0.00e+00	1462.00
IUUC-Pan-092545	Papio anubis	79.80	0.00e+00	1478.00
IUUC-Pma-094167	Petromyzon marinus	33.65	6.00e-66	245.00
IUUC-Pfo-096976	Poecilia formosa	45.62	0.00e+00	830.00
IUUC-Pab-098481	Pongo abelii	80.20	0.00e+00	1463.00
IUUC-Pca-100135	Procavia capensis	71.34	0.00e+00	1174.00
IUUC-Pva-102127	Pteropus vampyrus	75.23	0.00e+00	1286.00
IUUC-Sar-113448	Sorex araneus	70.46	0.00e+00	858.00
IUUC-Tru-118708	Takifugu rubripes	45.06	0.00e+00	766.00
IUUC-Tni-120172	Tetraodon nigroviridis	37.09	4.00e-34	138.00
IUUC-Tbe-127661	Tupaia belangeri	79.25	0.00e+00	716.00
IUUC-Ttr-128318	Tursiops truncatus	72.02	0.00e+00	1259.00
IUUC-Vpa-130502	Vicugna pacos	69.58	4.00e-147	515.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence