iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000167487.11	ENST00000300976.8	ENSP00000300976.3
ENSG00000167487.11	ENST00000595182.5	ENSP00000472032.1
ENSG00000167487.11	ENST00000600657.5	ENSP00000470999.1
ENSG00000167487.11	ENST00000599006.5	ENSP00000472001.1
ENSG00000167487.11	ENST00000595423.1	ENSP00000469099.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	3.20e-17	64.3	64	128

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 2    DvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           Dv+l +++e f+ahk+vLaa+S++F+a+f+++++e   ++ +e+k+v++  +r++++F Y+ ++++
   Q: 64   DVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREAS-QDVIELKGVSARGLRHIIDFAYSAEVTL 128
           9**********************************97.***********************99875 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MAESGGSSGG AGGGGAFGAG PGPERPNSTA DKNGALKCTF SAPSHSTSLL QGLATLRAQG 60
QLLDVVLTIN REAFPAHKVV LAACSDYFRA MFTGGMREAS QDVIELKGVS ARGLRHIIDF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGACCTGGCC CCGCCCCGCC CCCCGCGTCT CGGTTTCCCG GGCCTGCGCG CGCGGCTCCC 60
GTCACTCGAA CGCGCGACGG CGGGGGGAAG ATGGCGGAGT CCGGCGGTAG CAGCGGTGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030588--KLHL26
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0009566--P:fertilization
GO:0008584--P:male gonad development
GO:0016567--P:protein ubiquitination
GO:0007286--P:spermatid development

KEGG

hsa:55295

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001402	Ailuropoda melanoleuca	95.45	0.00e+00	1145.00
IUUC-Apl-003300	Anas platyrhynchos	87.46	0.00e+00	1093.00
IUUC-Ame-011584	Astyanax mexicanus	80.51	0.00e+00	1030.00
IUUC-Bta-012402	Bos taurus	95.76	0.00e+00	1143.00
IUUC-Cja-018924	Callithrix jacchus	98.48	0.00e+00	1215.00
IUUC-Cfa-020636	Canis familiaris	96.94	0.00e+00	1089.00
IUUC-Cpo-021941	Cavia porcellus	96.45	0.00e+00	1158.00
IUUC-Csa-023356	Chlorocebus sabaeus	99.49	0.00e+00	1220.00
IUUC-Dre-028497	Danio rerio	78.47	0.00e+00	1016.00
IUUC-Dor-030946	Dipodomys ordii	91.22	0.00e+00	1103.00
IUUC-Ete-032765	Echinops telfairi	89.55	0.00e+00	825.00
IUUC-Eca-034375	Equus caballus	97.28	0.00e+00	1163.00
IUUC-Fca-035395	Felis catus	96.44	0.00e+00	1155.00
IUUC-Gga-040727	Gallus gallus	86.56	0.00e+00	1092.00
IUUC-Gac-042613	Gasterosteus aculeatus	78.10	0.00e+00	970.00
IUUC-Ggo-044733	Gorilla gorilla	100.00	0.00e+00	1229.00
IUUC-Itr-048637	Ictidomys tridecemlineatus	98.46	0.00e+00	1199.00
IUUC-Lch-050650	Latimeria chalumnae	83.33	0.00e+00	1027.00
IUUC-Loc-052188	Lepisosteus oculatus	82.00	0.00e+00	1050.00
IUUC-Laf-053579	Loxodonta africana	90.48	0.00e+00	1059.00
IUUC-Mga-059249	Meleagris gallopavo	86.94	0.00e+00	1087.00
IUUC-Mdo-063072	Monodelphis domestica	88.16	0.00e+00	1115.00
IUUC-Mmu-063877	Mus musculus	87.37	0.00e+00	1018.00
IUUC-Mpu-066150	Mustela putorius furo	96.25	0.00e+00	1148.00
IUUC-Mlu-067962	Myotis lucifugus	94.26	0.00e+00	1170.00
IUUC-Ont-071425	Oreochromis niloticus	78.61	0.00e+00	1018.00
IUUC-Oan-072956	Ornithorhynchus anatinus	87.61	0.00e+00	1106.00
IUUC-Ocu-074355	Oryctolagus cuniculus	79.93	0.00e+00	876.00
IUUC-Ola-086522	Oryzias latipes	78.94	0.00e+00	1005.00
IUUC-Oga-088507	Otolemur garnettii	97.29	0.00e+00	1200.00
IUUC-Oar-090031	Ovis aries	92.72	0.00e+00	1054.00
IUUC-Ptr-090900	Pan troglodytes	100.00	0.00e+00	1229.00
IUUC-Pan-092359	Papio anubis	99.83	0.00e+00	1228.00
IUUC-Psi-093835	Pelodiscus sinensis	85.37	0.00e+00	1081.00
IUUC-Pma-094664	Petromyzon marinus	69.97	0.00e+00	849.00
IUUC-Pfo-097033	Poecilia formosa	79.12	0.00e+00	1027.00
IUUC-Pab-098078	Pongo abelii	96.79	0.00e+00	1181.00
IUUC-Pyt-104494	Pyrenophora triticirepentis	33.78	3.00e-06	46.20
IUUC-Rno-104856	Rattus norvegicus	87.54	0.00e+00	1019.00
IUUC-Sha-107619	Sarcophilus harrisii	88.57	0.00e+00	1115.00
IUUC-Sar-113357	Sorex araneus	88.01	0.00e+00	723.00
IUUC-Ssc-116320	Sus scrofa	96.60	0.00e+00	1149.00
IUUC-Tgu-116735	Taeniopygia guttata	87.74	0.00e+00	994.00
IUUC-Tru-118763	Takifugu rubripes	80.31	0.00e+00	1032.00
IUUC-Tni-120390	Tetraodon nigroviridis	79.80	0.00e+00	1027.00
IUUC-Ttr-128222	Tursiops truncatus	95.78	0.00e+00	1152.00
IUUC-Xtr-132327	Xenopus tropicalis	82.82	0.00e+00	1051.00
IUUC-Xma-133126	Xiphophorus maculatus	78.00	0.00e+00	1020.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence