iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000167671.11	ENST00000591919.5	ENSP00000467206.1
ENSG00000167671.11	ENST00000301281.10	ENSP00000301281.5
ENSG00000167671.11	ENST00000590466.2	ENSP00000466148.2
ENSG00000167671.11	ENST00000592515.1	ENSP00000464967.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UFD/UBX	UBX	26362318

Classification

Family	E-value	Score	Start	End
ULD/UDP/UFD/UBX	1.80e-13	52.5	334	408

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UFD/UBX

   S: 3    teqatlqiRlpdGkrlvrkFpssttleqiyqfveyllvessdpFeLvspfPrrtlkpeehmstlqeagLvpsgsllv 79
           ++++ l++RlpdG+ l+ +F ++++l ++y fv ++l++++ pFeL+++  +++ ++e+    l+e+gLvps+ l++
   Q: 334  YNYTLLRVRLPDGCLLQGTFYARERLGAVYGFVREALQSDWLPFELLASGGQKLSEDENL--ALNECGLVPSALLTF 408
           67899*******************************************************..***********9986 PP

Organism

Homo sapiens

Functional Description
(View)

Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. MDM2 stabilization leads to MDM2-dependent TP53 degradation.

Protein Sequence
(Fasta)

MKKFFQEFKA DIKFKSAGPG QKLKESVGEK AHKEKPNQPA PRPPRQGPTN EAQMAAAAAL 60
ARLEQKQSRA WGPTSQDTIR NQVRKELQAE ATVSGSPEAP GTNVVSEPRE EGSAHLAVPG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTTTTTTT TTTTTTTTTT TTTTTTTAAT TTTCTTCCGG TGGCTGGTCT CCGGCGGCCC 60
CGTCCCCGAC TGGGCCCCGT GCCCCCCCGC CCCCGCGGCC CCCCGCCGCC GGGCCAGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR018997--PUB_domain
IPR029071--Ubiquitin-rel_dom
IPR001012--UBX_dom

PROSITE

PS50033--UBX

Pfam

PF09409--PUB
PF00789--UBX

SMART

SM00580--PUG
SM00166--UBX

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005815--C:microtubule organizing center
GO:0005634--C:nucleus

KEGG

hsa:80700

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001103	Aegilops tauschii	42.86	5.00e-10	58.90
IUUC-Aml-001394	Ailuropoda melanoleuca	86.20	0.00e+00	696.00
IUUC-Atr-002503	Amborella trichopoda	29.18	2.00e-23	103.00
IUUC-Apl-003287	Anas platyrhynchos	65.46	9.00e-127	446.00
IUUC-Aca-004441	Anolis carolinensis	67.46	3.00e-144	504.00
IUUC-Aly-005477	Arabidopsis lyrata	28.62	5.00e-17	82.40
IUUC-Ath-007053	Arabidopsis thaliana	30.35	2.00e-16	80.50
IUUC-Ame-011784	Astyanax mexicanus	58.01	3.00e-124	438.00
IUUC-Bta-012994	Bos taurus	87.98	0.00e+00	742.00
IUUC-Bdi-014901	Brachypodium distachyon	30.66	3.00e-23	103.00
IUUC-Bol-016357	Brassica oleracea	32.82	1.00e-18	87.80
IUUC-Bra-017774	Brassica rapa	29.81	2.00e-20	94.00
IUUC-Cel-018297	Caenorhabditis elegans	31.45	2.00e-34	139.00
IUUC-Cja-019065	Callithrix jacchus	90.45	0.00e+00	778.00
IUUC-Cfa-020323	Canis familiaris	83.45	0.00e+00	711.00
IUUC-Cpo-022404	Cavia porcellus	79.24	0.00e+00	684.00
IUUC-Csa-023284	Chlorocebus sabaeus	96.14	0.00e+00	839.00
IUUC-Cin-025536	Ciona intestinalis	34.13	4.00e-44	172.00
IUUC-Csv-026209	Ciona savignyi	36.79	2.00e-32	132.00
IUUC-Dre-028550	Danio rerio	53.38	5.00e-101	361.00
IUUC-Dno-029718	Dasypus novemcinctus	76.11	9.00e-171	593.00
IUUC-Dor-030284	Dipodomys ordii	78.69	8.00e-179	619.00
IUUC-Dme-031962	Drosophila melanogaster	37.92	1.00e-48	187.00
IUUC-Ete-032636	Echinops telfairi	71.89	9.00e-72	264.00
IUUC-Eca-033672	Equus caballus	88.02	5.00e-170	590.00
IUUC-Fca-036036	Felis catus	87.39	2.00e-57	213.00
IUUC-Fal-037624	Ficedula albicollis	61.33	4.00e-113	401.00
IUUC-Gmo-039105	Gadus morhua	51.53	4.00e-105	374.00
IUUC-Gga-040449	Gallus gallus	63.45	2.00e-138	486.00
IUUC-Gac-042028	Gasterosteus aculeatus	53.50	1.00e-107	383.00
IUUC-Gma-042762	Glycine max	30.71	9.00e-20	91.70
IUUC-Ggo-044540	Gorilla gorilla	99.27	0.00e+00	813.00
IUUC-Hvu-047208	Hordeum vulgare	33.53	9.00e-19	87.00
IUUC-Itr-048940	Ictidomys tridecemlineatus	84.39	0.00e+00	717.00
IUUC-Lch-050216	Latimeria chalumnae	59.82	7.00e-133	467.00
IUUC-Lpe-051136	Leersia perrieri	28.13	3.00e-23	103.00
IUUC-Loc-052086	Lepisosteus oculatus	57.14	3.00e-109	388.00
IUUC-Laf-053998	Loxodonta africana	74.77	0.00e+00	644.00
IUUC-Mcc-055877	Macaca mulatta	96.59	0.00e+00	843.00
IUUC-Meu-056058	Macropus eugenii	55.56	3.00e-112	398.00
IUUC-Mtr-058198	Medicago truncatula	31.02	2.00e-20	94.00
IUUC-Mga-060105	Meleagris gallopavo	63.68	3.00e-144	504.00
IUUC-Mmr-061059	Microcebus murinus	88.21	0.00e+00	764.00
IUUC-Mdo-061899	Monodelphis domestica	74.15	4.00e-177	613.00
IUUC-Mmu-064178	Mus musculus	80.95	0.00e+00	676.00
IUUC-Mac-064698	Musa acuminata	33.33	3.00e-26	113.00
IUUC-Mpu-065804	Mustela putorius furo	87.07	0.00e+00	749.00
IUUC-Mlu-067204	Myotis lucifugus	85.26	0.00e+00	710.00
IUUC-Nle-069663	Nomascus leucogenys	97.50	0.00e+00	852.00
IUUC-Opr-071214	Ochotona princeps	83.93	8.00e-166	576.00
IUUC-Ont-071987	Oreochromis niloticus	55.37	4.00e-101	361.00
IUUC-Oan-073484	Ornithorhynchus anatinus	56.11	9.00e-106	377.00
IUUC-Ocu-073988	Oryctolagus cuniculus	60.54	6.00e-108	384.00
IUUC-Oba-075124	Oryza barthii	33.99	4.00e-18	84.70
IUUC-Obr-076731	Oryza brachyantha	29.43	1.00e-21	97.40
IUUC-Ogl-077903	Oryza glaberrima	34.64	1.00e-15	76.30
IUUC-Ogu-078325	Oryza glumaepatula	28.62	2.00e-22	100.00
IUUC-Oin-079788	Oryza indica	33.99	2.00e-17	82.80
IUUC-Olo-080748	Oryza longistaminata	32.03	2.00e-13	71.60
IUUC-Ome-081645	Oryza meridionalis	27.88	1.00e-21	97.80
IUUC-Oni-082890	Oryza nivara	28.62	3.00e-22	99.80
IUUC-Opu-083357	Oryza punctata	29.26	3.00e-22	99.40
IUUC-Oru-084284	Oryza rufipogon	28.25	2.00e-22	99.80
IUUC-Osa-086240	Oryza sativa	33.99	4.00e-18	84.70
IUUC-Ola-087409	Oryzias latipes	55.78	1.00e-105	376.00
IUUC-Olu-087606	Ostreococcus lucimarinus	37.80	2.00e-07	50.10
IUUC-Oga-089065	Otolemur garnettii	87.33	0.00e+00	755.00
IUUC-Oar-090352	Ovis aries	87.53	0.00e+00	697.00
IUUC-Ptr-091500	Pan troglodytes	98.86	0.00e+00	857.00
IUUC-Pan-092827	Papio anubis	96.59	0.00e+00	843.00
IUUC-Psi-093445	Pelodiscus sinensis	66.84	5.00e-141	493.00
IUUC-Pfo-096895	Poecilia formosa	57.29	5.00e-75	274.00
IUUC-Pab-098545	Pongo abelii	97.50	0.00e+00	838.00
IUUC-Pop-099215	Populus trichocarpa	30.51	8.00e-25	108.00
IUUC-Pca-100335	Procavia capensis	85.03	0.00e+00	743.00
IUUC-Ppe-101911	Prunus persica	27.08	6.00e-24	105.00
IUUC-Pva-103169	Pteropus vampyrus	74.55	9.00e-169	586.00
IUUC-Rno-106064	Rattus norvegicus	80.50	0.00e+00	671.00
IUUC-Sce-106458	Saccharomyces cerevisiae	33.63	5.00e-05	42.40
IUUC-Sha-107437	Sarcophilus harrisii	77.24	4.00e-53	199.00
IUUC-Sit-110426	Setaria italica	29.74	5.00e-23	102.00
IUUC-Sly-111225	Solanum lycopersicum	32.48	2.00e-24	107.00
IUUC-Stu-112826	Solanum tuberosum	32.22	8.00e-23	101.00
IUUC-Sar-113312	Sorex araneus	84.35	6.00e-132	463.00
IUUC-Sbi-114391	Sorghum bicolor	29.85	4.00e-21	95.90
IUUC-Sre-114935	Sporisorium reilianum	28.83	1.00e-06	46.60
IUUC-Ssc-115396	Sus scrofa	87.98	0.00e+00	711.00
IUUC-Tgu-116843	Taeniopygia guttata	63.48	8.00e-118	416.00
IUUC-Tru-118747	Takifugu rubripes	53.85	1.00e-103	370.00
IUUC-Tni-120834	Tetraodon nigroviridis	54.33	2.00e-102	366.00
IUUC-Tca-121181	Theobroma cacao	28.92	3.00e-22	100.00
IUUC-Tae-122844	Triticum aestivum	30.37	3.00e-26	112.00
IUUC-Tur-126442	Triticum urartu	30.74	2.00e-26	112.00
IUUC-Tbe-127541	Tupaia belangeri	71.59	2.00e-153	535.00
IUUC-Ttr-129191	Tursiops truncatus	84.81	0.00e+00	717.00
IUUC-Uma-129497	Ustilago maydis	28.95	2.00e-06	46.20
IUUC-Vvi-130861	Vitis vinifera	30.33	1.00e-25	110.00
IUUC-Xtr-132485	Xenopus tropicalis	54.73	3.00e-118	418.00
IUUC-Xma-133953	Xiphophorus maculatus	57.35	3.00e-93	335.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence