iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000167716.18	ENST00000468539.5	ENSP00000460742.1
ENSG00000167716.18	ENST00000409644.5	ENSP00000386609.1
ENSG00000167716.18	ENST00000575206.1	ENSP00000458811.1
ENSG00000167716.18	ENST00000474958.2	ENSP00000466240.1
ENSG00000167716.18	ENST00000437219.6	ENSP00000391074.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Disease-associated Variation
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.00e-13	49.7	1646	1676

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gH++ v c+a  s+ ++++sGs D t+++W 
   Q: 1646 GHSGAVKCVAPlSSeDFFLSGSKDRTVRLWP 1676
           8*********77555***************7 PP

Organism

Homo sapiens

Functional Description
(View)

Seems to have a role in maintenance of normal mitochondrial structure and organization. Promotes Purkinje and photoreceptor cell survival.

Protein Sequence
(Fasta)

MAQGSGGREG ALRTPAGGWH SPPSPDMQEL LRSVERDLSI DPRQLAPAPG GTHVVALVPA 60
RWLASLRDRR LPLGPCPRAE GLGEAEVRTL LQRSVQRLPA GWTRVEVHGL RKRRLSYPLG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAACGAGAGT CCTAAAGAGC AGGCGAAAGC CACGGCGTCT GCGTTTGCAA TGCATGCTGG 60
TCCGTGTAGT TCTCAGCCTG ACACCGTCGT TCCCAGAACC CAGCGCGCTC TGTGAGTTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0991--Mental retardation
KW-0496--Mitochondrion
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0809--Transit peptide
KW-0853--WD repeat

Interpro

IPR011989--ARM-like
IPR000409--BEACH_dom
IPR011009--Kinase-like_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50197--BEACH
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF02138--Beach
PF00400--WD40

SMART

SM01026--Beach
SM00320--WD40

Gene Ontology

GO:0005739--C:mitochondrion
GO:0010923--P:negative regulation of phosphatase activity

KEGG

hsa:124997

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001149	Aegilops tauschii	39.00	3.00e-73	270.00
IUUC-Aml-001469	Ailuropoda melanoleuca	89.07	0.00e+00	3101.00
IUUC-Atr-003087	Amborella trichopoda	39.95	1.00e-72	269.00
IUUC-Apl-003320	Anas platyrhynchos	66.62	0.00e+00	899.00
IUUC-Aca-004757	Anolis carolinensis	66.06	3.00e-121	427.00
IUUC-Ath-007144	Arabidopsis thaliana	40.52	8.00e-69	256.00
IUUC-Ame-011832	Astyanax mexicanus	54.88	0.00e+00	1932.00
IUUC-Bta-012569	Bos taurus	89.82	0.00e+00	1481.00
IUUC-Bdi-014656	Brachypodium distachyon	38.94	1.00e-74	276.00
IUUC-Bol-016288	Brassica oleracea	40.21	8.00e-71	263.00
IUUC-Bra-017480	Brassica rapa	36.98	1.00e-54	209.00
IUUC-Cel-018315	Caenorhabditis elegans	46.91	5.00e-63	236.00
IUUC-Cja-019992	Callithrix jacchus	91.76	0.00e+00	1432.00
IUUC-Cfa-020689	Canis familiaris	88.59	0.00e+00	3230.00
IUUC-Cpo-021489	Cavia porcellus	90.11	0.00e+00	1454.00
IUUC-Csa-023209	Chlorocebus sabaeus	97.22	0.00e+00	3430.00
IUUC-Csv-025966	Ciona savignyi	30.04	4.00e-103	370.00
IUUC-Dre-027665	Danio rerio	51.73	0.00e+00	1873.00
IUUC-Dno-029751	Dasypus novemcinctus	87.01	0.00e+00	3137.00
IUUC-Dor-030379	Dipodomys ordii	91.13	0.00e+00	1496.00
IUUC-Dme-032002	Drosophila melanogaster	34.11	1.00e-100	362.00
IUUC-Eca-033529	Equus caballus	92.49	0.00e+00	1517.00
IUUC-Eeu-034915	Erinaceus europaeus	88.29	0.00e+00	1548.00
IUUC-Fca-036329	Felis catus	89.83	0.00e+00	3237.00
IUUC-Fal-037479	Ficedula albicollis	64.53	0.00e+00	1308.00
IUUC-Gmo-038831	Gadus morhua	69.94	1.00e-143	503.00
IUUC-Gga-040649	Gallus gallus	65.32	0.00e+00	1427.00
IUUC-Gac-041852	Gasterosteus aculeatus	70.32	3.00e-146	511.00
IUUC-Gma-043542	Glycine max	38.72	1.00e-73	272.00
IUUC-Ggo-044633	Gorilla gorilla	99.02	0.00e+00	3451.00
IUUC-Hvu-047635	Hordeum vulgare	37.44	9.00e-71	262.00
IUUC-Itr-048923	Ictidomys tridecemlineatus	89.26	0.00e+00	3180.00
IUUC-Lch-049479	Latimeria chalumnae	58.96	0.00e+00	2197.00
IUUC-Lpe-051541	Leersia perrieri	39.20	2.00e-76	281.00
IUUC-Loc-051885	Lepisosteus oculatus	59.77	0.00e+00	854.00
IUUC-Laf-053778	Loxodonta africana	89.76	0.00e+00	3326.00
IUUC-Mcc-055759	Macaca mulatta	97.53	0.00e+00	1552.00
IUUC-Meu-056896	Macropus eugenii	77.53	0.00e+00	1269.00
IUUC-Mtr-058486	Medicago truncatula	39.61	2.00e-68	255.00
IUUC-Mga-059219	Meleagris gallopavo	66.56	0.00e+00	1098.00
IUUC-Mmr-061010	Microcebus murinus	92.17	0.00e+00	3229.00
IUUC-Mdo-062572	Monodelphis domestica	75.75	0.00e+00	2667.00
IUUC-Mmu-063810	Mus musculus	85.83	0.00e+00	3144.00
IUUC-Mpu-066257	Mustela putorius furo	92.56	0.00e+00	1289.00
IUUC-Mlu-068111	Myotis lucifugus	90.93	0.00e+00	1498.00
IUUC-Nle-069919	Nomascus leucogenys	98.12	0.00e+00	2001.00
IUUC-Opr-071204	Ochotona princeps	85.94	0.00e+00	907.00
IUUC-Ont-072131	Oreochromis niloticus	55.58	0.00e+00	878.00
IUUC-Oan-072888	Ornithorhynchus anatinus	75.00	0.00e+00	1112.00
IUUC-Ocu-074626	Oryctolagus cuniculus	89.24	0.00e+00	3164.00
IUUC-Oba-075734	Oryza barthii	38.85	1.00e-73	272.00
IUUC-Obr-076493	Oryza brachyantha	39.00	7.00e-75	276.00
IUUC-Ogl-077248	Oryza glaberrima	38.85	1.00e-73	272.00
IUUC-Ogu-077961	Oryza glumaepatula	38.50	3.00e-72	268.00
IUUC-Oin-079930	Oryza indica	38.85	9.00e-75	276.00
IUUC-Olo-080512	Oryza longistaminata	38.52	1.00e-69	259.00
IUUC-Ome-081701	Oryza meridionalis	38.85	6.00e-75	276.00
IUUC-Oni-082138	Oryza nivara	38.69	5.00e-74	273.00
IUUC-Opu-083350	Oryza punctata	38.82	3.00e-73	271.00
IUUC-Oru-085133	Oryza rufipogon	38.85	7.00e-74	273.00
IUUC-Osa-086042	Oryza sativa	38.85	9.00e-75	276.00
IUUC-Ola-086950	Oryzias latipes	51.84	0.00e+00	833.00
IUUC-Oga-088547	Otolemur garnettii	93.15	0.00e+00	1509.00
IUUC-Oar-089796	Ovis aries	86.96	0.00e+00	2451.00
IUUC-Ptr-091248	Pan troglodytes	99.18	0.00e+00	3466.00
IUUC-Pan-091811	Papio anubis	96.60	0.00e+00	3428.00
IUUC-Psi-093656	Pelodiscus sinensis	76.52	1.00e-144	506.00
IUUC-Pfo-096830	Poecilia formosa	52.74	0.00e+00	1845.00
IUUC-Pab-098361	Pongo abelii	98.25	0.00e+00	1187.00
IUUC-Pop-100019	Populus trichocarpa	39.20	7.00e-70	259.00
IUUC-Pca-100269	Procavia capensis	89.06	9.00e-172	597.00
IUUC-Ppe-101526	Prunus persica	38.86	8.00e-69	256.00
IUUC-Pva-102214	Pteropus vampyrus	89.60	0.00e+00	1391.00
IUUC-Rno-105590	Rattus norvegicus	86.31	0.00e+00	3086.00
IUUC-Sha-106620	Sarcophilus harrisii	77.18	0.00e+00	1212.00
IUUC-Sit-109791	Setaria italica	38.10	1.00e-75	278.00
IUUC-Sly-111032	Solanum lycopersicum	39.24	8.00e-67	249.00
IUUC-Sbi-114810	Sorghum bicolor	37.91	7.00e-74	273.00
IUUC-Ssc-115972	Sus scrofa	73.94	0.00e+00	864.00
IUUC-Tgu-116944	Taeniopygia guttata	71.70	0.00e+00	1055.00
IUUC-Tru-118685	Takifugu rubripes	51.20	0.00e+00	854.00
IUUC-Tsy-119279	Tarsius syrichta	89.66	0.00e+00	1399.00
IUUC-Tni-120124	Tetraodon nigroviridis	55.91	0.00e+00	915.00
IUUC-Tca-121706	Theobroma cacao	40.15	3.00e-72	268.00
IUUC-Tae-125578	Triticum aestivum	39.00	4.00e-73	270.00
IUUC-Tur-126547	Triticum urartu	39.08	2.00e-73	271.00
IUUC-Tbe-128035	Tupaia belangeri	80.17	0.00e+00	729.00
IUUC-Ttr-128162	Tursiops truncatus	91.21	0.00e+00	1415.00
IUUC-Vvi-131247	Vitis vinifera	39.10	4.00e-72	267.00
IUUC-Xtr-132225	Xenopus tropicalis	61.36	0.00e+00	1025.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence