iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.80e-28	96.7	339	374
UBD/Beta-Prp	1.00e-47	163.2	337	622

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           H ++v++++f ++  ll++G+ D  i++W++  g+l
   Q: 339  HLSEVNAVCFaPNsSLLATGGADRLIHLWNVVGGRL 374
           99*********7779***************987765 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkl..lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkgh 93
           ++h s +++v+f+p++sllatg++d+ i +w+v  g l   ++l+g  + +t+v+f+p+g+  + +   +++++w +   +   tl+gh
   Q: 337  DAHLSEVNAVCFAPNSSLLATGGADRLIHLWNVVGGRLeaNQTLEGAGGSITSVDFDPSGSQVLAATYNQAAQLWKVGETQSKETLSGH 425
           789999********************************88899******************9999999********************* PP
   S: 94   edsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtds 182
           +d+v++ +f  +++  v+Gs+drt++ wdl   +c++ t ++ +    c  v + + +++sG++D+++r+Wd++   +++      +++
   Q: 426  KDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSR-TINVLS---YCNDVVCGDHIIISGHNDQKIRFWDSRGPHCIQVIP--VQGR 508
           ************************************9.666655...4555555556*************************5..589* PP
   S: 183  vyslsfdsngkelvsgsldgtvklwdlqtgec.....vrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnss 266
           v+sl++++++ +l+s+s+d+t+k+ dl+ +++      + +++ +d++k   fsp+  + ++gss g+++iWd+ +g+l ++lq+++ +
   Q: 509  VTSLNLSHDQLHLLSCSRDNTLKVIDLRISNIrqvfrADGFKCSSDWTK-AVFSPDRSYALVGSSNGTLYIWDVNTGKLETSLQGPHCT 596
           ****************************666634444566666777777.7799*********************************77 PP
   S: 267  visvavlsfgdnvlvlgsedskvniw 292
            +   +++f++n++v++++  kv +w
   Q: 597  AVNAVAWCFSGNHVVSVDQVRKVVLW 622
           7777778***********99999999 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MAGPSAPCDP CAPVAAWKRH ILRQLRHRDR TQKALFLELV PAYNHLLEKA ELLAKFSEKL 60
KSEPKDVIST PHQDSREEAS GTGPDQVSSP ASLKVKWQQE KKGLQLVCGE MAYQVVRKSA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGGAC CCAGCGCCCC CTGCGATCCC TGCGCGCCCG TTGCCGCCTG GAAGCGCCAC 60
ATCCTGCGAC AGCTGCGGCA TCGGGACCGC ACGCAAAAGG CGCTCTTCTT GGAGCTAGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR013923--Autophagy-rel_prot_16
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08614--ATG16
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0000421--C:autophagosome membrane
GO:0005654--C:nucleoplasm
GO:0000045--P:autophagosome assembly
GO:0039689--P:negative stranded viral RNA replication

KEGG

rno:308865

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001470	Ailuropoda melanoleuca	64.96	0.00e+00	728.00
IUUC-Aca-004664	Anolis carolinensis	67.46	9.00e-102	362.00
IUUC-Ame-011152	Astyanax mexicanus	42.09	4.00e-120	425.00
IUUC-Bta-013118	Bos taurus	79.45	0.00e+00	886.00
IUUC-Cja-020002	Callithrix jacchus	81.49	0.00e+00	903.00
IUUC-Cfa-020878	Canis familiaris	78.87	0.00e+00	878.00
IUUC-Cpo-022476	Cavia porcellus	80.71	0.00e+00	880.00
IUUC-Csa-024134	Chlorocebus sabaeus	80.80	0.00e+00	895.00
IUUC-Cho-024853	Choloepus hoffmanni	67.32	2.00e-174	605.00
IUUC-Dre-027949	Danio rerio	41.15	1.00e-126	447.00
IUUC-Dno-029683	Dasypus novemcinctus	79.96	0.00e+00	748.00
IUUC-Dor-030897	Dipodomys ordii	74.44	0.00e+00	899.00
IUUC-Ete-032957	Echinops telfairi	89.64	2.00e-129	456.00
IUUC-Eca-033303	Equus caballus	87.35	1.00e-161	561.00
IUUC-Eeu-035336	Erinaceus europaeus	70.97	3.00e-148	518.00
IUUC-Fca-036232	Felis catus	81.12	0.00e+00	956.00
IUUC-Gmo-038880	Gadus morhua	49.30	9.00e-70	258.00
IUUC-Gac-042500	Gasterosteus aculeatus	40.26	4.00e-91	328.00
IUUC-Ggo-045130	Gorilla gorilla	87.34	0.00e+00	681.00
IUUC-Hsa-046359	Homo sapiens	82.18	0.00e+00	874.00
IUUC-Itr-048780	Ictidomys tridecemlineatus	82.49	0.00e+00	946.00
IUUC-Lch-050669	Latimeria chalumnae	51.12	6.00e-96	343.00
IUUC-Loc-052789	Lepisosteus oculatus	41.80	1.00e-116	414.00
IUUC-Laf-053699	Loxodonta africana	80.67	0.00e+00	900.00
IUUC-Mcc-055657	Macaca mulatta	76.24	0.00e+00	807.00
IUUC-Meu-056639	Macropus eugenii	48.83	4.00e-109	389.00
IUUC-Mmr-061314	Microcebus murinus	73.12	0.00e+00	800.00
IUUC-Mdo-061841	Monodelphis domestica	63.55	0.00e+00	702.00
IUUC-Mmu-064065	Mus musculus	95.22	0.00e+00	1107.00
IUUC-Mpu-066742	Mustela putorius furo	78.46	0.00e+00	868.00
IUUC-Mlu-067019	Myotis lucifugus	81.25	0.00e+00	798.00
IUUC-Nle-069037	Nomascus leucogenys	82.51	0.00e+00	916.00
IUUC-Opr-071039	Ochotona princeps	76.40	0.00e+00	857.00
IUUC-Oan-073431	Ornithorhynchus anatinus	72.22	2.00e-140	491.00
IUUC-Ocu-074772	Oryctolagus cuniculus	79.59	0.00e+00	806.00
IUUC-Ola-086964	Oryzias latipes	51.92	4.00e-83	301.00
IUUC-Oga-088188	Otolemur garnettii	80.06	0.00e+00	845.00
IUUC-Oar-090231	Ovis aries	73.81	0.00e+00	862.00
IUUC-Ptr-091434	Pan troglodytes	79.93	0.00e+00	836.00
IUUC-Pan-091868	Papio anubis	81.38	0.00e+00	891.00
IUUC-Psi-093652	Pelodiscus sinensis	64.27	3.00e-164	571.00
IUUC-Pfo-096960	Poecilia formosa	41.42	3.00e-99	355.00
IUUC-Pab-097776	Pongo abelii	81.88	0.00e+00	832.00
IUUC-Pca-100220	Procavia capensis	62.12	2.00e-171	595.00
IUUC-Pva-103135	Pteropus vampyrus	81.45	0.00e+00	845.00
IUUC-Sha-107062	Sarcophilus harrisii	63.75	0.00e+00	734.00
IUUC-Sar-113109	Sorex araneus	63.55	2.00e-129	455.00
IUUC-Ssc-115271	Sus scrofa	79.97	0.00e+00	882.00
IUUC-Ttr-128267	Tursiops truncatus	76.89	0.00e+00	832.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence