iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
ICGC	COSMIC	CGAP	IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	dbPTM	UniProt
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	20852630

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	8.90e-05	24.6	12	52

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlC 45
           Ca+C+  +++ p+  +CgH f++ C+   w     ++ + f CP C
   Q: 12   CALCQRAPRE-PVRADCGHRFCRACVvRFW----AEEDGPFPCPEC 52
           ****999988.777***********97778....99*********9 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8.

Protein Sequence
(Fasta)

LALPAGPAEA ACALCQRAPR EPVRADCGHR FCRACVVRFW AEEDGPFPCP ECADDCWQRA 60
VEPGRPPLSR RLLALEEAAA APARDGPASE AALQLLCRAD AGPLCAACRM AAGPEPPEWE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGCAGGCAG TAGAGTGAAG CGCGCAGCTG CCAGGACTTG CGCGGTGACG TGCGCCGCTG 60
CCAGGACCTT GCAGGTGGAG AGCATAGTTG CCAAAATCAA GGCGGAGGAG CGCACCGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00097--zf-C3HC4

SMART

SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0008284--P:positive regulation of cell proliferation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination

KEGG

hsa:149603

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002191	Ailuropoda melanoleuca	88.68	1.00e-50	190.00
IUUC-Bgr-012065	Blumeria graminis	32.81	6.60e-02	33.10
IUUC-Bta-012513	Bos taurus	92.77	1.00e-93	335.00
IUUC-Cja-019008	Callithrix jacchus	90.98	1.00e-59	221.00
IUUC-Cpo-022460	Cavia porcellus	88.07	4.00e-75	274.00
IUUC-Csa-024164	Chlorocebus sabaeus	100.00	8.00e-62	228.00
IUUC-Dno-029128	Dasypus novemcinctus	86.79	5.00e-35	138.00
IUUC-Ete-033026	Echinops telfairi	82.43	5.00e-16	75.50
IUUC-Eca-034206	Equus caballus	90.48	2.00e-37	146.00
IUUC-Fca-035393	Felis catus	73.38	8.00e-40	155.00
IUUC-Ggo-045548	Gorilla gorilla	100.00	8.00e-62	228.00
IUUC-Itr-047955	Ictidomys tridecemlineatus	92.38	2.00e-52	197.00
IUUC-Laf-054276	Loxodonta africana	90.99	4.00e-43	166.00
IUUC-Mcc-054972	Macaca mulatta	100.00	1.00e-95	342.00
IUUC-Mmu-063109	Mus musculus	94.92	2.00e-97	348.00
IUUC-Mpu-066574	Mustela putorius furo	84.54	2.00e-29	121.00
IUUC-Mlu-067760	Myotis lucifugus	94.55	2.00e-94	338.00
IUUC-Nle-069556	Nomascus leucogenys	97.35	6.00e-60	222.00
IUUC-Ocu-074636	Oryctolagus cuniculus	83.06	7.00e-54	202.00
IUUC-Oga-088384	Otolemur garnettii	95.45	4.00e-91	327.00
IUUC-Oar-090060	Ovis aries	91.39	1.00e-59	222.00
IUUC-Ptr-090496	Pan troglodytes	100.00	1.00e-57	214.00
IUUC-Pan-091825	Papio anubis	100.00	1.00e-95	342.00
IUUC-Pab-098001	Pongo abelii	92.31	4.00e-16	75.50
IUUC-Pca-100168	Procavia capensis	91.89	7.00e-38	149.00
IUUC-Rno-105436	Rattus norvegicus	94.92	2.00e-97	348.00
IUUC-Tbe-127513	Tupaia belangeri	64.00	1.00e-27	114.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence