iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000168826.15	ENST00000515012.5	ENSP00000422321.1
ENSG00000168826.15	ENST00000337872.8	ENSP00000338807.4
ENSG00000168826.15	ENST00000503703.5	ENSP00000424525.1
ENSG00000168826.15	ENST00000504302.1	ENSP00000421654.1
ENSG00000168826.15	ENST00000511458.1	ENSP00000426765.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.80e-12	49.1	25	90

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +D++lvv+g+ f+ahk vLaa S++F++lf++  ++++     ++k    +   ++l+F+Yt+ ld+n
   Q: 25   CDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNSSSQKNDVFHLDVK--NVSGIGQILDFMYTSHLDLN 90
           8*****************************9988876545555555..8899**************98 PP

Organism

Homo sapiens

Functional Description
(View)

Isoform 3: Activates RB1 transcription most probably by antagonizing ZBTB17 repression of RB1. Does not bind directly RB1 promoter.

Protein Sequence
(Fasta)

MDPVATHSCH LLQQLHEQRI QGLLCDCMLV VKGVCFKAHK NVLAAFSQYF RSLFQNSSSQ 60
KNDVFHLDVK NVSGIGQILD FMYTSHLDLN QDNIQVMLDT AQCLQVQNVL SLCHTFLKSA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTGTCGTGA TGATTCCGCG GCCAGCGGAT CGCTGCGAGT GGCCTTGAAG GCAGCTGCTG 60
CAGGTGAAGA GTAGGCGGCG GGGCAGAGAG CGGCCTCCGA GGGTAAGGTG GCCGGCCTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR020542--Asp_carbamoyltrfase_reg_C
IPR000210--BTB/POZ_dom
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0015630--C:microtubule cytoskeleton
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0001223--F:transcription coactivator binding
GO:0008134--F:transcription factor binding
GO:0007050--P:cell cycle arrest
GO:0008285--P:negative regulation of cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:166793

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002380	Ailuropoda melanoleuca	80.26	0.00e+00	1192.00
IUUC-Apl-003402	Anas platyrhynchos	73.27	0.00e+00	1129.00
IUUC-Aca-005251	Anolis carolinensis	58.63	0.00e+00	842.00
IUUC-Ame-011624	Astyanax mexicanus	78.87	6.00e-97	348.00
IUUC-Bta-013500	Bos taurus	80.16	0.00e+00	1186.00
IUUC-Cja-019265	Callithrix jacchus	92.69	0.00e+00	1370.00
IUUC-Cfa-020468	Canis familiaris	81.46	0.00e+00	1206.00
IUUC-Cpo-021937	Cavia porcellus	74.25	0.00e+00	1038.00
IUUC-Csa-023216	Chlorocebus sabaeus	96.87	0.00e+00	1452.00
IUUC-Dre-028348	Danio rerio	75.00	1.00e-96	347.00
IUUC-Dno-029339	Dasypus novemcinctus	82.51	0.00e+00	1231.00
IUUC-Dor-030277	Dipodomys ordii	83.11	4.00e-105	375.00
IUUC-Dme-032129	Drosophila melanogaster	49.40	6.00e-20	94.00
IUUC-Eca-033669	Equus caballus	83.92	0.00e+00	1261.00
IUUC-Fca-035639	Felis catus	71.91	0.00e+00	1009.00
IUUC-Fal-037462	Ficedula albicollis	68.36	0.00e+00	979.00
IUUC-Gmo-039476	Gadus morhua	71.49	4.00e-92	332.00
IUUC-Gac-041549	Gasterosteus aculeatus	46.57	2.00e-169	589.00
IUUC-Ggo-044866	Gorilla gorilla	99.09	0.00e+00	1487.00
IUUC-Itr-048707	Ictidomys tridecemlineatus	83.53	0.00e+00	1179.00
IUUC-Lch-050388	Latimeria chalumnae	56.96	0.00e+00	859.00
IUUC-Loc-052002	Lepisosteus oculatus	52.60	0.00e+00	709.00
IUUC-Laf-054184	Loxodonta africana	81.46	0.00e+00	1196.00
IUUC-Mcc-055715	Macaca mulatta	97.26	0.00e+00	1457.00
IUUC-Mga-059724	Meleagris gallopavo	73.14	0.00e+00	1127.00
IUUC-Mdo-062942	Monodelphis domestica	75.91	0.00e+00	1118.00
IUUC-Mmu-064042	Mus musculus	74.28	0.00e+00	1085.00
IUUC-Mpu-066682	Mustela putorius furo	74.22	4.00e-176	610.00
IUUC-Mlu-068067	Myotis lucifugus	76.86	0.00e+00	1185.00
IUUC-Nle-070108	Nomascus leucogenys	97.91	0.00e+00	1466.00
IUUC-Opr-070475	Ochotona princeps	70.18	0.00e+00	962.00
IUUC-Ont-072124	Oreochromis niloticus	45.74	5.00e-174	604.00
IUUC-Oan-073392	Ornithorhynchus anatinus	56.83	1.00e-66	247.00
IUUC-Ocu-074120	Oryctolagus cuniculus	75.10	0.00e+00	1064.00
IUUC-Ola-087133	Oryzias latipes	45.04	3.00e-161	562.00
IUUC-Oga-088105	Otolemur garnettii	85.36	0.00e+00	1290.00
IUUC-Oar-089685	Ovis aries	62.44	0.00e+00	687.00
IUUC-Ptr-090971	Pan troglodytes	99.74	0.00e+00	1493.00
IUUC-Pan-092567	Papio anubis	96.74	0.00e+00	1441.00
IUUC-Psi-093775	Pelodiscus sinensis	74.71	0.00e+00	1109.00
IUUC-Pma-094193	Petromyzon marinus	55.70	6.00e-47	181.00
IUUC-Pfo-096353	Poecilia formosa	45.59	6.00e-164	571.00
IUUC-Pab-097617	Pongo abelii	97.91	0.00e+00	1469.00
IUUC-Pva-102633	Pteropus vampyrus	78.82	0.00e+00	1170.00
IUUC-Rno-105385	Rattus norvegicus	72.32	0.00e+00	1056.00
IUUC-Sha-107166	Sarcophilus harrisii	67.96	0.00e+00	954.00
IUUC-Sar-113012	Sorex araneus	72.09	0.00e+00	756.00
IUUC-Ssc-116285	Sus scrofa	76.53	0.00e+00	1114.00
IUUC-Tgu-117060	Taeniopygia guttata	70.87	0.00e+00	1054.00
IUUC-Tru-118102	Takifugu rubripes	45.69	7.00e-162	564.00
IUUC-Tni-120447	Tetraodon nigroviridis	52.97	2.00e-156	546.00
IUUC-Tbe-127463	Tupaia belangeri	84.69	0.00e+00	677.00
IUUC-Ttr-128785	Tursiops truncatus	82.11	0.00e+00	1232.00
IUUC-Vpa-130467	Vicugna pacos	79.58	0.00e+00	785.00
IUUC-Xtr-131986	Xenopus tropicalis	53.33	3.00e-149	522.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence