iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000001829.7	ENSRNOT00000031401.4	ENSRNOP00000062102.1
ENSRNOG00000001829.7	ENSRNOT00000088212.1	ENSRNOP00000068914.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.90e-19	70.2	30	136
E2/UEV	5.50e-66	221.2	5	143

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E2/UBC

   S: 16   gisakpvdesd..ltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.Gkv...ClsilkeeekWspalsv 98
           ++s +++d++d  lt+w  +i+Gp++t+Ye+++++l++e+ ++YP  PP+v+f+tki    ++++ G v    + +l    kW+  +s+
   Q: 30   TVSWGLEDDEDmtLTRWTGMIIGPPRTNYENRIYSLKVECGSKYPEAPPSVRFVTKINMNGINNSsGMVdarSIPVL---AKWQNSYSI 115
           456667777776689******************************************99999999899943335555...7******** PP
   S: 99   esvllsiqsll.aepnpespl 118
           + vl ++ +l+ ++ n++ p+
   Q: 116  KVVLQELRRLMmSKENMKLPQ 136
           *********996667777775 PP

E2/UEV

   S: 7    lkvvvprnfrlleeleegekglgdgtvsygldDgddilllsltgtIigpertayegrIyqlklfvgkkYPekPPtvrfsskinmaevnd 95
           + v+vprnfrlleeleeg+kg+gdgtvs+gl+D++d++l+++tg+Iigp+rt+ye+rIy+lk+++g+kYPe+PP vrf++kinm+++n+
   Q: 5    TGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYENRIYSLKVECGSKYPEAPPSVRFVTKINMNGINN 93
           689************************************************************************************** PP
   S: 96   snGvvdpralpvLanWkreysievvlvqlkkellskenrklqqPpeGnlf 145
           s+G+vd+r++pvLa+W+++ysi+vvl++l++ ++sken+kl+qPpeG+++
   Q: 94   SSGMVDARSIPVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQTY 143
           ***********************************************986 PP

Organism

Rattus norvegicus

Functional Description
(View)

Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.

Protein Sequence
(Fasta)

MAVSTGVKVP RNFRLLEELE EGQKGVGDGT VSWGLEDDED MTLTRWTGMI IGPPRTNYEN 60
RIYSLKVECG SKYPEAPPSV RFVTKINMNG INNSSGMVDA RSIPVLAKWQ NSYSIKVVLQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGTGCGGCG GTGCGTCTGG TAGAAGGAGA AGATGGCGGT GTCCACAGGT TGGTTCCTAG 60
CCCTGGTCGC CGCGTTCTCC CTGCTGGCTG TCCGGCGGGC CACGCGGGAC TGCGGGTGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031372--C:UBC13-MMS2 complex
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0000729--P:DNA double-strand break processing
GO:0042275--P:error-free postreplication DNA repair
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0045739--P:positive regulation of DNA repair
GO:0010976--P:positive regulation of neuron projection development
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0051965--P:positive regulation of synapse assembly
GO:0006301--P:postreplication repair
GO:0070534--P:protein K63-linked ubiquitination

KEGG

rno:287927

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001275	Ailuropoda melanoleuca	99.29	3.00e-79	286.00
IUUC-Apl-003790	Anas platyrhynchos	97.84	7.00e-70	255.00
IUUC-Aca-004448	Anolis carolinensis	97.84	5.00e-70	256.00
IUUC-Aly-006115	Arabidopsis lyrata	54.14	5.00e-38	149.00
IUUC-Ate-010471	Aspergillus terreus	44.20	2.00e-28	117.00
IUUC-Bgr-012010	Blumeria graminis	49.64	3.00e-33	134.00
IUUC-Bta-012471	Bos taurus	99.31	5.00e-82	295.00
IUUC-Bra-017054	Brassica rapa	52.99	1.00e-37	148.00
IUUC-Cel-018398	Caenorhabditis elegans	63.77	3.00e-47	180.00
IUUC-Cja-019506	Callithrix jacchus	98.62	8.00e-82	295.00
IUUC-Cfa-020370	Canis familiaris	99.31	5.00e-82	295.00
IUUC-Cpo-021317	Cavia porcellus	96.55	1.00e-79	287.00
IUUC-Csa-023412	Chlorocebus sabaeus	99.31	5.00e-82	295.00
IUUC-Cho-025024	Choloepus hoffmanni	98.89	1.00e-48	183.00
IUUC-Cne-026817	Cryptococcus neoformans	47.45	3.00e-37	147.00
IUUC-Dre-028062	Danio rerio	93.10	5.00e-78	282.00
IUUC-Dno-029546	Dasypus novemcinctus	99.29	3.00e-79	286.00
IUUC-Dor-030185	Dipodomys ordii	92.73	2.00e-26	112.00
IUUC-Dse-031272	Dothistroma septosporum	50.00	8.00e-35	139.00
IUUC-Fca-035746	Felis catus	99.29	4.00e-79	286.00
IUUC-Fal-037369	Ficedula albicollis	96.55	2.00e-70	257.00
IUUC-Gmo-039696	Gadus morhua	84.03	2.00e-68	250.00
IUUC-Ggr-039839	Gaeumannomyces graminis	46.50	1.00e-30	125.00
IUUC-Gga-040634	Gallus gallus	96.55	2.00e-70	257.00
IUUC-Gac-041936	Gasterosteus aculeatus	83.33	6.00e-62	229.00
IUUC-Ggo-044696	Gorilla gorilla	99.31	5.00e-82	295.00
IUUC-Hsa-046699	Homo sapiens	99.31	5.00e-82	295.00
IUUC-Itr-048151	Ictidomys tridecemlineatus	99.31	5.00e-82	295.00
IUUC-Kpa-049337	Komagataella pastoris	49.63	6.00e-31	125.00
IUUC-Lpe-050874	Leersia perrieri	53.73	2.00e-38	151.00
IUUC-Loc-052012	Lepisosteus oculatus	93.10	9.00e-78	281.00
IUUC-Lma-053194	Leptosphaeria maculans	50.00	2.00e-34	137.00
IUUC-Laf-053991	Loxodonta africana	98.57	1.00e-78	285.00
IUUC-Mcc-055850	Macaca mulatta	99.29	2.00e-79	287.00
IUUC-Mor-056915	Magnaporthe oryzae	37.09	6.00e-21	93.20
IUUC-Mpo-057437	Magnaporthe poae	45.86	2.00e-30	124.00
IUUC-Mla-058919	Melampsora laricipopulina	53.24	1.00e-34	138.00
IUUC-Mga-059210	Meleagris gallopavo	97.84	5.00e-70	255.00
IUUC-Mvi-060260	Microbotryum violaceum	53.28	4.00e-36	143.00
IUUC-Mmr-061751	Microcebus murinus	97.93	2.00e-80	290.00
IUUC-Mdo-062503	Monodelphis domestica	97.24	7.00e-73	265.00
IUUC-Mmu-063294	Mus musculus	99.31	1.00e-82	297.00
IUUC-Mpu-065942	Mustela putorius furo	99.31	5.00e-82	295.00
IUUC-Mlu-067702	Myotis lucifugus	99.29	4.00e-79	286.00
IUUC-Ncr-068946	Neurospora crassa	45.86	5.00e-37	146.00
IUUC-Nle-069327	Nomascus leucogenys	99.31	5.00e-82	295.00
IUUC-Opr-070697	Ochotona princeps	83.45	9.00e-62	228.00
IUUC-Ont-072098	Oreochromis niloticus	88.19	6.00e-66	242.00
IUUC-Oan-073215	Ornithorhynchus anatinus	89.80	3.00e-66	243.00
IUUC-Ocu-073859	Oryctolagus cuniculus	99.31	5.00e-82	295.00
IUUC-Obr-076238	Oryza brachyantha	52.99	3.00e-38	150.00
IUUC-Olo-080242	Oryza longistaminata	48.94	3.00e-39	154.00
IUUC-Ola-087529	Oryzias latipes	86.81	3.00e-65	239.00
IUUC-Olu-087815	Ostreococcus lucimarinus	41.23	6.00e-21	93.20
IUUC-Oar-090010	Ovis aries	99.29	3.00e-79	286.00
IUUC-Ptr-091024	Pan troglodytes	99.29	3.00e-79	286.00
IUUC-Pan-091955	Papio anubis	99.31	5.00e-82	295.00
IUUC-Psi-093138	Pelodiscus sinensis	96.55	2.00e-70	257.00
IUUC-Pno-095070	Phaeosphaeria nodorum	50.72	2.00e-35	140.00
IUUC-Pfo-096483	Poecilia formosa	88.89	3.00e-66	243.00
IUUC-Pab-098753	Pongo abelii	99.31	5.00e-82	295.00
IUUC-Pva-102989	Pteropus vampyrus	99.31	5.00e-82	295.00
IUUC-Pgr-103617	Puccinia graminis	52.17	2.00e-32	130.00
IUUC-Ptt-104008	Puccinia triticina	44.93	1.00e-16	78.60
IUUC-Pte-104176	Pyrenophora teres	50.00	3.00e-35	140.00
IUUC-Pyt-104517	Pyrenophora triticirepentis	50.00	3.00e-35	140.00
IUUC-Sce-106349	Saccharomyces cerevisiae	49.26	2.00e-32	130.00
IUUC-Sha-106779	Sarcophilus harrisii	97.24	4.00e-73	266.00
IUUC-Sja-107722	Schizosaccharomyces japonicus	52.55	2.00e-33	134.00
IUUC-Spo-108027	Schizosaccharomyces pombe	49.64	2.00e-32	130.00
IUUC-Sar-113406	Sorex araneus	70.00	4.00e-49	186.00
IUUC-Ssc-115259	Sus scrofa	97.22	7.00e-80	288.00
IUUC-Tgu-116732	Taeniopygia guttata	97.83	2.00e-69	254.00
IUUC-Tru-118526	Takifugu rubripes	86.96	4.00e-54	202.00
IUUC-Tni-120169	Tetraodon nigroviridis	85.52	3.00e-56	209.00
IUUC-Tre-121971	Trichoderma reesei	52.52	3.00e-37	147.00
IUUC-Tme-127171	Tuber melanosporum	46.72	1.00e-29	122.00
IUUC-Tbe-127265	Tupaia belangeri	92.86	2.00e-64	237.00
IUUC-Ttr-128959	Tursiops truncatus	98.62	8.00e-82	295.00
IUUC-Xtr-131975	Xenopus tropicalis	92.41	8.00e-78	281.00
IUUC-Xma-133222	Xiphophorus maculatus	88.89	2.00e-66	244.00
IUUC-Yli-134591	Yarrowia lipolytica	50.50	7.00e-28	114.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence