iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000169871.12	ENST00000306085.10	ENSP00000305161.6
ENSG00000169871.12	ENST00000412507.1	ENSP00000404186.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	21074459; 21289118

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	9.70e-06	27.7	21	60

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iCle ++  p++lpC H++++dCl ++        ++ rCP Cr
   Q: 21   CKICLEQLRA-PKTLPCLHTYCQDCLAQL-----ADGGRVRCPECR 60
           99******99.***************555.....499999*****8 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets TMEM173/STING to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity). Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160).

Protein Sequence
(Fasta)

MVSHGSSPSL LEALSSDFLA CKICLEQLRA PKTLPCLHTY CQDCLAQLAD GGRVRCPECR 60
ETVPVPPEGV ASFKTNFFVN GLLDLVKARA CGDLRAGKPA CALCPLVGGT STGGPATARC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTGGCTGGG ACGGAAGTTG CACCACAAGT ACAATTAGTT TCAGTTTTGT TTCTTTTCCA 60
GGCACCCAGC AACGGCGGCC TCCAGGCCTC AGGCCCCCTC ACCATCCTAG AGGTCAAGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0051--Antiviral defense
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0399--Innate immunity
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00643--zf-B_box
PF13445--zf-RING_UBOX

SMART

SM00336--BBOX
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0051607--P:defense response to virus
GO:0032608--P:interferon-beta production
GO:0070534--P:protein K63-linked ubiquitination
GO:0032479--P:regulation of type I interferon production
GO:0034340--P:response to type I interferon

KEGG

hsa:81844

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001496	Ailuropoda melanoleuca	90.01	0.00e+00	1159.00
IUUC-Aca-004996	Anolis carolinensis	53.76	1.00e-75	278.00
IUUC-Bta-012368	Bos taurus	86.89	0.00e+00	1172.00
IUUC-Cja-019698	Callithrix jacchus	94.57	0.00e+00	1278.00
IUUC-Csa-023090	Chlorocebus sabaeus	97.09	0.00e+00	1231.00
IUUC-Dno-030051	Dasypus novemcinctus	80.33	0.00e+00	981.00
IUUC-Ete-032312	Echinops telfairi	88.94	5.00e-94	336.00
IUUC-Eca-033253	Equus caballus	92.65	6.00e-107	380.00
IUUC-Eeu-034772	Erinaceus europaeus	81.16	2.00e-52	199.00
IUUC-Fca-036198	Felis catus	84.27	0.00e+00	916.00
IUUC-Ggo-045486	Gorilla gorilla	98.94	0.00e+00	1259.00
IUUC-Itr-048481	Ictidomys tridecemlineatus	86.62	0.00e+00	1103.00
IUUC-Loc-052915	Lepisosteus oculatus	29.62	5.00e-68	252.00
IUUC-Laf-053640	Loxodonta africana	85.05	0.00e+00	1066.00
IUUC-Mcc-055540	Macaca mulatta	97.22	0.00e+00	1244.00
IUUC-Mmr-060840	Microcebus murinus	90.33	0.00e+00	1163.00
IUUC-Mmu-064375	Mus musculus	80.69	0.00e+00	1057.00
IUUC-Mpu-066797	Mustela putorius furo	88.59	0.00e+00	1147.00
IUUC-Mlu-067996	Myotis lucifugus	88.07	0.00e+00	1149.00
IUUC-Nle-069238	Nomascus leucogenys	99.26	5.00e-127	446.00
IUUC-Oga-089156	Otolemur garnettii	85.45	0.00e+00	1153.00
IUUC-Oar-090056	Ovis aries	81.93	0.00e+00	1035.00
IUUC-Ptr-090837	Pan troglodytes	98.48	0.00e+00	778.00
IUUC-Psi-093493	Pelodiscus sinensis	45.49	3.00e-59	223.00
IUUC-Pab-097607	Pongo abelii	98.41	0.00e+00	1283.00
IUUC-Pva-102758	Pteropus vampyrus	86.36	0.00e+00	1128.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence