iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046464

UUCD1 version

UUC-HoS-01197

Ensembl Protein ID

ENSP00000473639.1

UniProt Accession

Q969T4; B2RAD6; D3DPG3; Q5U0R7; Q7Z4W4; UB2E3_HUMAN

Genbank Protein ID

BAA76544.1; AAD40197.1; AAP97266.1; AAV38152.1; BAG36833.1; AAY14882.1; EAX10989.1; EAX10990.1; AAH03554.1; AAH92407.1

Protein Name

Ubiquitin-conjugating enzyme E2 E3; E2 ubiquitin-conjugating enzyme E3; UbcH9; Ubiquitin carrier protein E3; Ubiquitin-conjugating enzyme E2-23 kDa; Ubiquitin-protein ligase E3

Genbank Nucleotide ID

AB017644; AF085362; AF136176; BT019345; AK314145; AC104076; CH471058; CH471058; BC003554; BC092407

Gene Name

UBE2E3; UBCE4; UBCH9

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000170035.15	ENST00000602959.5	ENSP00000473639.1
ENSG00000170035.15	ENST00000602475.5	ENSP00000473264.1
ENSG00000170035.15	ENST00000602632.1	ENSP00000473642.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	18597043; 11823428

Classification

Family	E-value	Score	Start	End
E2/UBC	1.00e-49	169.5	65	200

Active Site

Position(s)	Description	Evidence
145	Glycyl thioester intermediate	N/A

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekW 92
           R++kel+e++ dpp+++sa+p+ + +++ew+ +ilGp++++YeggvF l+i+f++dYPfkPPkv+f t+i+h+n++++G +Cl+ilk  ++W
   Q: 65   RIQKELAEITLDPPPNCSAGPKGD-NIYEWRSTILGPPGSVYEGGVFFLDITFSSDYPFKPPKVTFRTRIYHCNINSQGVICLDILK--DNW 153
           9***********************.9************************************************************9..*** PP
   S: 93   spalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvre 139
           spal++++vllsi+sll+++np++pl  ++a+++ +nr+e+++++r+
   Q: 154  SPALTISKVLLSICSLLTDCNPADPLVGSIATQYLTNRAEHDRIARQ 200
           *****************************************999875 PP

Organism

Homo sapiens

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest.

Protein Sequence
(Fasta)

MSSDRQRSDD ESPSTSSGSS DADQRDPAAP EPEEQEERKP SATQQKKNTK LSSKTTAKLS 60
TSAKRIQKEL AEITLDPPPN CSAGPKGDNI YEWRSTILGP PGSVYEGGVF FLDITFSSDY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAATATGAAG AGCTACGGCC AAGTTCATGC AGTCACAGGC AATGACAACT ATATCACCAA 60
TGCTGCCTGG CTGAGAGTGA TTTAAGACAT CATTGATTGG AAGGTATATT TTTATTTGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0341--Growth regulation
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0070979--P:protein K11-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0040008--P:regulation of growth

KEGG

hsa:10477

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000463	Aegilops tauschii	64.34	6.00e-53	202.00
IUUC-Apl-003415	Anas platyrhynchos	99.52	2.00e-89	321.00
IUUC-Aca-005276	Anolis carolinensis	99.52	6.00e-90	323.00
IUUC-Bta-012796	Bos taurus	98.55	2.00e-86	311.00
IUUC-Cja-019670	Callithrix jacchus	100.00	2.00e-89	321.00
IUUC-Cfa-021171	Canis familiaris	100.00	2.00e-89	321.00
IUUC-Csa-023464	Chlorocebus sabaeus	99.52	4.00e-89	320.00
IUUC-Cme-027286	Cyanidioschyzon merolae	72.62	2.00e-70	258.00
IUUC-Dre-027376	Danio rerio	100.00	5.00e-84	303.00
IUUC-Ete-032812	Echinops telfairi	100.00	6.00e-84	302.00
IUUC-Eca-033312	Equus caballus	100.00	2.00e-89	321.00
IUUC-Eeu-035232	Erinaceus europaeus	100.00	6.00e-84	302.00
IUUC-Fal-036688	Ficedula albicollis	99.52	2.00e-89	321.00
IUUC-Gga-040613	Gallus gallus	99.52	2.00e-89	321.00
IUUC-Ggo-045068	Gorilla gorilla	96.14	1.00e-83	301.00
IUUC-Itr-048624	Ictidomys tridecemlineatus	100.00	4.00e-74	269.00
IUUC-Loc-052492	Lepisosteus oculatus	96.17	3.00e-87	314.00
IUUC-Laf-054416	Loxodonta africana	100.00	2.00e-89	321.00
IUUC-Mcc-055754	Macaca mulatta	99.52	4.00e-89	320.00
IUUC-Mtr-058214	Medicago truncatula	60.26	1.00e-54	205.00
IUUC-Mga-059436	Meleagris gallopavo	99.52	2.00e-89	321.00
IUUC-Mmr-060893	Microcebus murinus	99.03	1.00e-92	332.00
IUUC-Mdo-063010	Monodelphis domestica	100.00	2.00e-89	321.00
IUUC-Mmu-063493	Mus musculus	100.00	2.00e-89	321.00
IUUC-Mpu-065789	Mustela putorius furo	100.00	2.00e-89	321.00
IUUC-Mlu-066934	Myotis lucifugus	99.52	3.00e-89	320.00
IUUC-Nle-069930	Nomascus leucogenys	100.00	2.00e-89	321.00
IUUC-Opr-070917	Ochotona princeps	94.74	8.00e-60	221.00
IUUC-Ocu-074769	Oryctolagus cuniculus	97.10	2.00e-85	308.00
IUUC-Olu-087783	Ostreococcus lucimarinus	77.86	2.00e-65	240.00
IUUC-Oga-088760	Otolemur garnettii	100.00	2.00e-89	321.00
IUUC-Oar-090077	Ovis aries	100.00	1.00e-89	322.00
IUUC-Ptr-091596	Pan troglodytes	97.10	3.00e-84	304.00
IUUC-Pan-092142	Papio anubis	99.52	4.00e-89	320.00
IUUC-Psi-093471	Pelodiscus sinensis	99.52	2.00e-89	321.00
IUUC-Ppa-095789	Physcomitrella patens	78.38	4.00e-69	253.00
IUUC-Pab-098675	Pongo abelii	100.00	2.00e-89	321.00
IUUC-Pop-099024	Populus trichocarpa	65.03	9.00e-58	215.00
IUUC-Pca-100467	Procavia capensis	100.00	2.00e-89	321.00
IUUC-Ppe-101314	Prunus persica	59.72	1.00e-53	202.00
IUUC-Pva-103205	Pteropus vampyrus	100.00	2.00e-89	321.00
IUUC-Rno-105806	Rattus norvegicus	87.50	4.00e-86	310.00
IUUC-Smo-109298	Selaginella moellendorffii	69.74	5.00e-63	233.00
IUUC-Sly-111200	Solanum lycopersicum	61.54	1.00e-54	205.00
IUUC-Sar-113672	Sorex araneus	100.00	2.00e-89	321.00
IUUC-Tgu-116892	Taeniopygia guttata	99.52	2.00e-89	321.00
IUUC-Tsy-119046	Tarsius syrichta	99.52	7.00e-89	319.00
IUUC-Tca-121777	Theobroma cacao	63.19	1.00e-55	209.00
IUUC-Tbe-127690	Tupaia belangeri	100.00	3.00e-86	310.00
IUUC-Ttr-128849	Tursiops truncatus	100.00	2.00e-89	321.00
IUUC-Vvi-131190	Vitis vinifera	61.84	6.00e-56	209.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence