iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000170185.9	ENST00000510377.5	ENSP00000427647.1
ENSG00000170185.9	ENST00000307017.8	ENSP00000303434.4
ENSG00000170185.9	ENST00000511739.1	ENSP00000424158.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	12401499; 14715245

Classification

Family	E-value	Score	Start	End
DUB/USP	7.70e-83	280.1	445	949

Active Site

Position(s)	Description	Evidence
454	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
857	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDa 92
           tGl NlgNtCYmNSv+Q+L++ +++r+++l+ + + +n         +l+k+lq+lf+ l +++++a++pr +++a +   + f+  +qqD+
   Q: 445  TGLINLGNTCYMNSVIQALFMATDFRRQVLSLNLNGCN---------SLMKKLQHLFAFLAHTQREAYAPRIFFEASR--PPWFTPRSQQDC 525
           7******************************5555554.........7***************************998..777********* PP
   S: 93   qEflaflldqleeelkk...eknkpkeeeeeedkselsde........aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldls 173
           +E+l+flld+l+ee k    +++++ +e  e ++++l++         +  ++   +k+li+++F+g+l+++i+cl+c+++s++ e f+dls
   Q: 526  SEYLRFLLDRLHEEEKIlkvQASHKPSEILECSETSLQEVaskaavltETPRTSDGEKTLIEKMFGGKLRTHIRCLNCRSTSQKVEAFTDLS 617
           **************95577788888888888888888888888999988888888999********************************** PP
   S: 174  lpvpgkeetkke................................................................................ 185
           l++  +++ ++                                                                                 
   Q: 618  LAFCPSSSLENMsvqdpasspsiqdgglmqasvpgpseepvvynpttaaficdslvnektigsppnefycsentsvpnesnkilvnkdvpqk 709
           ***9999776669******************************************************************************* PP
   S: 186  .......slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts... 267
                  s++d+L+ f ++e l+g+n+yyce+c ++q+aek++++++ Pe+Lil L Rfs++++ ++r+ki ++v++pl L+l    ++   
   Q: 710  pggettpSVTDLLNYFLAPEILTGDNQYYCENCASLQNAEKTMQITEEPEYLILTLLRFSYDQKYHVRRKILDNVSLPLVLELPVKRITsfs 801
           ******************************************************************************99999954444366 PP
   S: 268  ............................peekqkekkkYeLiavvvHsG.slssGHYvayvkn............................. 301
                                       +e + ++ + Y L++vvvHsG s++sGHY++y++n                             
   Q: 802  slseswsvdvdftdlsenlakklkpsgtDEASCTKLVPYLLSSVVVHSGiSSESGHYYSYARNitstdssyqmyhqsealalassqshllgr 893
           667777777777777777777777666644445559***********************************************999999999 PP
   S: 302  ...............ekgkWllfdDskVtevkeeevleetg....staYvlfYkrr 338
                           +++W+lf+Ds+Vt ++ ++v++ t+    +taYvl+Yk++
   Q: 894  dspsavfeqdlenkeMSKEWFLFNDSRVTFTSFQSVQKITSrfpkDTAYVLLYKKQ 949
           9999999988865544555*******************999************986 PP

Organism

Homo sapiens

Functional Description
(View)

Deubiquitinating enzyme exhibiting a preference towards 'Lys-63'-linked Ubiquitin chains.

Protein Sequence
(Fasta)

MDKILEGLVS SSHPLPLKRV IVRKVVESAE HWLDEAQCEA MFDLTTRLIL EGQDPFQRQV 60
GHQVLEAYAR YHRPEFESFF NKTFVLGLLH QGYHSLDRKD VAILDYIHNG LKLIMSCPSV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTTCAAAAT CCGGGTCAAA GGGTGTCGCT TCGGTCTCTT CTCCCCGGCT GATCCCAGCA 60
CTCTCCGTGA CAGCGCCTCC TGACTCAGCC CAGGACCGGC TTCTTCTCAC GACCTGCTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR033840--USP38
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:84640

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002174	Ailuropoda melanoleuca	93.02	0.00e+00	1858.00
IUUC-Apl-003435	Anas platyrhynchos	76.12	0.00e+00	1264.00
IUUC-Aca-004556	Anolis carolinensis	71.16	0.00e+00	1305.00
IUUC-Ame-010616	Astyanax mexicanus	62.52	0.00e+00	1238.00
IUUC-Bta-013544	Bos taurus	92.80	0.00e+00	1825.00
IUUC-Cja-018745	Callithrix jacchus	94.46	0.00e+00	1913.00
IUUC-Cfa-020434	Canis familiaris	89.35	0.00e+00	1784.00
IUUC-Cpo-021666	Cavia porcellus	91.84	0.00e+00	1785.00
IUUC-Csa-023965	Chlorocebus sabaeus	98.08	0.00e+00	2038.00
IUUC-Cho-024809	Choloepus hoffmanni	84.11	0.00e+00	1282.00
IUUC-Cin-025604	Ciona intestinalis	37.39	7.00e-41	161.00
IUUC-Csv-026333	Ciona savignyi	44.25	4.00e-32	131.00
IUUC-Dre-028338	Danio rerio	63.28	0.00e+00	1256.00
IUUC-Dno-029372	Dasypus novemcinctus	92.03	0.00e+00	1858.00
IUUC-Dor-030752	Dipodomys ordii	89.34	0.00e+00	1241.00
IUUC-Ete-032588	Echinops telfairi	79.87	0.00e+00	1133.00
IUUC-Eca-034416	Equus caballus	94.24	0.00e+00	1943.00
IUUC-Eeu-035132	Erinaceus europaeus	73.95	0.00e+00	1400.00
IUUC-Fca-036137	Felis catus	93.57	0.00e+00	1899.00
IUUC-Fal-037297	Ficedula albicollis	75.50	0.00e+00	1445.00
IUUC-Gmo-038727	Gadus morhua	66.92	0.00e+00	1028.00
IUUC-Gga-041091	Gallus gallus	74.02	0.00e+00	1399.00
IUUC-Gac-042082	Gasterosteus aculeatus	63.90	0.00e+00	1145.00
IUUC-Ggo-045376	Gorilla gorilla	94.74	0.00e+00	1888.00
IUUC-Itr-047976	Ictidomys tridecemlineatus	93.28	0.00e+00	1910.00
IUUC-Lch-050500	Latimeria chalumnae	71.89	0.00e+00	1430.00
IUUC-Loc-052625	Lepisosteus oculatus	64.78	0.00e+00	1308.00
IUUC-Laf-053689	Loxodonta africana	93.17	0.00e+00	1887.00
IUUC-Mcc-055286	Macaca mulatta	98.18	0.00e+00	1999.00
IUUC-Mga-059905	Meleagris gallopavo	74.23	0.00e+00	1233.00
IUUC-Mmr-061397	Microcebus murinus	95.30	0.00e+00	1915.00
IUUC-Mdo-062833	Monodelphis domestica	86.03	0.00e+00	1795.00
IUUC-Mmu-063157	Mus musculus	90.12	0.00e+00	1823.00
IUUC-Mpu-066434	Mustela putorius furo	94.15	0.00e+00	1922.00
IUUC-Mlu-068178	Myotis lucifugus	91.60	0.00e+00	1806.00
IUUC-Nle-070153	Nomascus leucogenys	98.27	0.00e+00	1949.00
IUUC-Ont-072330	Oreochromis niloticus	63.41	0.00e+00	1250.00
IUUC-Oan-072709	Ornithorhynchus anatinus	80.29	0.00e+00	1285.00
IUUC-Ocu-074832	Oryctolagus cuniculus	94.24	0.00e+00	1900.00
IUUC-Ola-087003	Oryzias latipes	55.17	3.00e-48	184.00
IUUC-Oga-088517	Otolemur garnettii	90.16	0.00e+00	1803.00
IUUC-Oar-089472	Ovis aries	89.16	0.00e+00	1753.00
IUUC-Ptr-090996	Pan troglodytes	99.62	0.00e+00	2027.00
IUUC-Pan-091837	Papio anubis	96.09	0.00e+00	1985.00
IUUC-Psi-093236	Pelodiscus sinensis	76.23	0.00e+00	1159.00
IUUC-Pma-094349	Petromyzon marinus	53.04	0.00e+00	983.00
IUUC-Pfo-097193	Poecilia formosa	61.94	0.00e+00	1163.00
IUUC-Pab-098710	Pongo abelii	98.75	0.00e+00	2031.00
IUUC-Pca-100794	Procavia capensis	81.98	0.00e+00	1645.00
IUUC-Pva-102722	Pteropus vampyrus	93.19	0.00e+00	1899.00
IUUC-Rno-105743	Rattus norvegicus	89.54	0.00e+00	1788.00
IUUC-Sha-106563	Sarcophilus harrisii	85.14	0.00e+00	1452.00
IUUC-Sar-113533	Sorex araneus	77.64	0.00e+00	1559.00
IUUC-Ssc-116259	Sus scrofa	83.94	0.00e+00	1585.00
IUUC-Tgu-117475	Taeniopygia guttata	75.89	0.00e+00	1318.00
IUUC-Tru-118623	Takifugu rubripes	63.09	0.00e+00	1160.00
IUUC-Tsy-119250	Tarsius syrichta	93.24	0.00e+00	1494.00
IUUC-Tni-120441	Tetraodon nigroviridis	59.59	0.00e+00	1077.00
IUUC-Tbe-127936	Tupaia belangeri	81.38	0.00e+00	1546.00
IUUC-Ttr-128483	Tursiops truncatus	80.72	0.00e+00	1412.00
IUUC-Vpa-130303	Vicugna pacos	97.94	0.00e+00	1078.00
IUUC-Xtr-132773	Xenopus tropicalis	72.46	0.00e+00	1418.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence