iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000027364.12	ENSMUST00000136319.7	ENSMUSP00000121578.1
ENSMUSG00000027364.12	ENSMUST00000028842.8	ENSMUSP00000028842.2
ENSMUSG00000027364.12	ENSMUST00000130356.1	ENSMUSP00000116873.1
ENSMUSG00000027364.12	ENSMUST00000099423.2	ENSMUSP00000127386.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.20e-88	297.8	45	361

Active Site

Position(s)	Description	Evidence
54	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
321	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgye 88
           tGl+NlgNtCYmN++LQcL ++++l e++l+ k+  +l+     ++  e++++++ l++ +w +++  vsp+ +l+a++++ + f +  
   Q: 45   TGLRNLGNTCYMNAILQCLCSVSPLVEYFLSgKYITALK-----KDCSEVTTAFAYLMTDMWLGDSDCVSPEIFLSAVGSLYPAFLKKT 128
           7******************************44444443.....5678***************************************** PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvp 177
           qqDaqEfl ++l++l+e+lkk+ + +++e+      ++ ++  +k + +++s+i++lF+gql+ +i+cl+c++ + ++e f+ lslp+p
   Q: 129  QQDAQEFLIYVLNELHEALKKHCRRRVNEK------RTGQSCCRKVPAQETSIITRLFEGQLSYSITCLKCESCTHKNEVFTILSLPIP 211
           *******************55333333333......34456679999****************************************** PP
   S: 178  gkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldlspfc 265
           ++ e+   slqdcL+ f+++++l+ +n++yc+ c+ kqea  +++++k+P+++++h+kRf  + ++ +++k+ + +++pl+ Ldl+p+ 
   Q: 212  SDYEC---SLQDCLQCFFQQDTLTWSNQIYCSFCEIKQEAAVRTTISKVPKIIVFHFKRF--DIQGTVKRKLRTDIHYPLTnLDLTPYI 295
           *****...****************************************************..67789********************** PP
   S: 266  tspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYk 336
           +   +k   +  Y+L+avv+H G l++GHY+a++kn+  + W+ fdD++V+e++ ++v++   +taY+lfY 
   Q: 296  CPVFRK---HPMYNLCAVVNHFGDLDGGHYTAFCKNSVTQaWYSFDDTRVSEIPDTSVQT---ATAYLLFYS 361
           *95544...89*************************98888*******************...********6 PP

Organism

Mus musculus

Functional Description
(View)

May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Protein Sequence
(Fasta)

MCFIDMASHR PVPADDFGAY YNLAECADYD SLPESKTQPH FQGVTGLRNL GNTCYMNAIL 60
QCLCSVSPLV EYFLSGKYIT ALKKDCSEVT TAFAYLMTDM WLGDSDCVSP EIFLSAVGSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGAGGATCC AAGAAGAACT GGGCCTGAGT CAAGTGAAAT CAGACAGCAA CAACACAAAG 60
GGGGGAGGGG GGCATTCAAA CGGTTCAAAA CCAAAAACAA GCCAGGGAGC AGTCCTGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:75083

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002089	Ailuropoda melanoleuca	83.11	0.00e+00	643.00
IUUC-Aca-005256	Anolis carolinensis	48.84	5.00e-101	361.00
IUUC-Bta-012753	Bos taurus	79.89	1.00e-177	615.00
IUUC-Cfa-020054	Canis familiaris	79.94	4.00e-160	557.00
IUUC-Cpo-021375	Cavia porcellus	77.18	1.00e-156	545.00
IUUC-Csa-023902	Chlorocebus sabaeus	77.73	8.00e-96	342.00
IUUC-Cho-024755	Choloepus hoffmanni	68.05	1.00e-131	462.00
IUUC-Dor-030311	Dipodomys ordii	81.32	1.00e-88	319.00
IUUC-Ete-032570	Echinops telfairi	64.04	3.00e-101	361.00
IUUC-Eca-034343	Equus caballus	81.38	0.00e+00	639.00
IUUC-Eeu-034510	Erinaceus europaeus	80.25	2.00e-154	537.00
IUUC-Fca-035920	Felis catus	82.84	0.00e+00	635.00
IUUC-Fal-036903	Ficedula albicollis	56.97	2.00e-105	375.00
IUUC-Gac-042261	Gasterosteus aculeatus	43.03	1.00e-73	270.00
IUUC-Ggo-045650	Gorilla gorilla	52.25	4.00e-81	294.00
IUUC-Hsa-046665	Homo sapiens	75.51	2.00e-149	521.00
IUUC-Itr-048167	Ictidomys tridecemlineatus	84.53	0.00e+00	662.00
IUUC-Lch-049925	Latimeria chalumnae	53.17	2.00e-104	372.00
IUUC-Loc-051880	Lepisosteus oculatus	49.54	5.00e-79	289.00
IUUC-Laf-054494	Loxodonta africana	81.57	0.00e+00	635.00
IUUC-Mcc-055507	Macaca mulatta	82.00	3.00e-171	594.00
IUUC-Meu-055906	Macropus eugenii	72.67	2.00e-143	501.00
IUUC-Mmr-061564	Microcebus murinus	60.36	1.00e-101	362.00
IUUC-Mdo-061800	Monodelphis domestica	75.07	3.00e-166	577.00
IUUC-Mpu-066699	Mustela putorius furo	82.57	0.00e+00	640.00
IUUC-Mlu-067672	Myotis lucifugus	80.91	0.00e+00	632.00
IUUC-Opr-070949	Ochotona princeps	77.78	3.00e-143	501.00
IUUC-Oan-073725	Ornithorhynchus anatinus	64.61	2.00e-139	488.00
IUUC-Ocu-074021	Oryctolagus cuniculus	84.32	0.00e+00	654.00
IUUC-Oga-088258	Otolemur garnettii	83.23	3.00e-157	547.00
IUUC-Oar-089881	Ovis aries	80.42	0.00e+00	626.00
IUUC-Ptr-090988	Pan troglodytes	76.12	1.00e-145	509.00
IUUC-Pan-091773	Papio anubis	82.53	0.00e+00	630.00
IUUC-Psi-093243	Pelodiscus sinensis	69.50	1.00e-134	472.00
IUUC-Pab-097713	Pongo abelii	77.62	1.00e-161	562.00
IUUC-Pca-100226	Procavia capensis	65.68	2.00e-124	438.00
IUUC-Pva-103172	Pteropus vampyrus	81.07	1.00e-164	572.00
IUUC-Rno-105950	Rattus norvegicus	92.47	0.00e+00	748.00
IUUC-Sha-107026	Sarcophilus harrisii	69.87	1.00e-163	568.00
IUUC-Ssc-116383	Sus scrofa	83.51	0.00e+00	652.00
IUUC-Tgu-116511	Taeniopygia guttata	55.49	2.00e-98	352.00
IUUC-Tbe-127808	Tupaia belangeri	76.64	5.00e-57	214.00
IUUC-Ttr-129046	Tursiops truncatus	79.29	6.00e-157	546.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence