iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein 3D Structure
PDB	MMDB
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UBL/ATG8	7.60e-50	167.7	13	116

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/ATG8

   S: 1    krkeevekirdkfpdkiPvivekakkekipeldkkkylvPsdltvgqlvkiirkrlqlraedalfllvnnslvsvsatlaeiyeeekdedgflyvayaseet 102
           kr++e++kir k+pd+iPviveka+k+k+ +ldkkkylvPsdltvgq++++irkr+qlr+edalf++vnn+++ + +t++++y+++++ed fly+ay++e++
   Q: 13   KRRAEGDKIRRKYPDRIPVIVEKAPKSKLHDLDKKKYLVPSDLTVGQFYFLIRKRIQLRPEDALFFFVNNVIPQTMTTMGQLYQDHHEEDLFLYIAYSDESV 114
           699*************************************************************************************************** PP
   S: 103  fG 104
           +G
   Q: 115  YG 116
           *9 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Ubiquitin-like modifier involved in autophagy and essential for dauer development and life-span extension (PubMed:12958363, PubMed:20523114). Plays a role in the distribution and clearance of germ cell specific P-granules from somatic cells (PubMed:19167332). Required for normal survival when exposed to pathogenic bacteria S.typhimurium probably by promoting autophagic degradation of intracellular S.typhimurium (PubMed:19667176). Plays a role in mitophagy (PubMed:25896323).

Protein Sequence
(Fasta)

MKWAYKEENN FEKRRAEGDK IRRKYPDRIP VIVEKAPKSK LHDLDKKKYL VPSDLTVGQF 60
YFLIRKRIQL RPEDALFFFV NNVIPQTMTT MGQLYQDHHE EDLFLYIAYS DESVYGGEVE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAACCTTCTC TTCACACTAA CCTTCGAATC AAAATGAAGT GGGCTTACAA GGAGGAGAAC 60
AACTTTGAGA AGCGTCGTGC CGAAGGAGAC AAGATCCGCA GAAAGTACCC AGACCGTATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0449--Lipoprotein
KW-0496--Mitochondrion
KW-1185--Reference proteome

Interpro

IPR004241--Atg8-like
IPR029071--Ubiquitin-rel_dom

Pfam

PF02991--Atg8

Gene Ontology

GO:0005776--C:autophagosome
GO:0000421--C:autophagosome membrane
GO:0005737--C:cytoplasm
GO:0031410--C:cytoplasmic vesicle
GO:0005741--C:mitochondrial outer membrane
GO:0005634--C:nucleus
GO:0000407--C:pre-autophagosomal structure
GO:0006914--P:autophagy
GO:0040024--P:dauer larval development
GO:0050830--P:defense response to Gram-positive bacterium
GO:0008340--P:determination of adult lifespan
GO:0010940--P:positive regulation of necrotic cell death
GO:0012501--P:programmed cell death

KEGG

cel:CELE_C32D5.9

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000059	Aegilops tauschii	54.31	2.00e-35	139.00
IUUC-Aml-001323	Ailuropoda melanoleuca	83.62	4.00e-55	204.00
IUUC-Atr-002842	Amborella trichopoda	57.52	1.00e-29	120.00
IUUC-Apl-003994	Anas platyrhynchos	78.45	6.00e-52	194.00
IUUC-Aca-004544	Anolis carolinensis	75.00	7.00e-49	184.00
IUUC-Aly-005408	Arabidopsis lyrata	60.53	7.00e-38	147.00
IUUC-Ath-006721	Arabidopsis thaliana	61.06	1.00e-37	146.00
IUUC-Ago-007898	Ashbya gossypii	48.70	2.00e-31	126.00
IUUC-Acl-008314	Aspergillus clavatus	56.90	6.00e-37	144.00
IUUC-Afl-008708	Aspergillus flavus	56.90	8.00e-37	144.00
IUUC-Afu-009097	Aspergillus fumigatus	56.90	6.00e-37	144.00
IUUC-Ani-009196	Aspergillus nidulans	56.90	9.00e-37	143.00
IUUC-Ang-009530	Aspergillus niger	56.90	6.00e-37	144.00
IUUC-Aor-009909	Aspergillus oryzae	56.90	8.00e-37	144.00
IUUC-Ate-010358	Aspergillus terreus	56.90	6.00e-37	144.00
IUUC-Ame-010914	Astyanax mexicanus	82.76	4.00e-54	201.00
IUUC-Bgr-012248	Blumeria graminis	56.41	5.00e-37	144.00
IUUC-Bta-012805	Bos taurus	83.62	4.00e-55	204.00
IUUC-Bci-013959	Botrytis cinerea	56.20	2.00e-37	146.00
IUUC-Bdi-014929	Brachypodium distachyon	55.65	8.00e-36	140.00
IUUC-Bol-015412	Brassica oleracea	57.89	1.00e-36	143.00
IUUC-Bra-016921	Brassica rapa	57.52	2.00e-37	145.00
IUUC-Cja-019369	Callithrix jacchus	83.62	4.00e-55	204.00
IUUC-Cfa-020603	Canis familiaris	83.62	4.00e-55	204.00
IUUC-Cpo-022522	Cavia porcellus	78.45	7.00e-52	194.00
IUUC-Cre-022866	Chlamydomonas reinhardtii	59.65	2.00e-33	132.00
IUUC-Csa-024117	Chlorocebus sabaeus	83.62	4.00e-55	204.00
IUUC-Cho-025008	Choloepus hoffmanni	74.14	9.00e-49	183.00
IUUC-Cin-025297	Ciona intestinalis	82.91	1.00e-55	206.00
IUUC-Cgl-026691	Colletotrichum gloeosporioides	41.61	6.00e-31	125.00
IUUC-Cne-026889	Cryptococcus neoformans	53.45	3.00e-35	138.00
IUUC-Dre-028351	Danio rerio	83.62	2.00e-55	206.00
IUUC-Dno-029218	Dasypus novemcinctus	83.78	5.00e-52	196.00
IUUC-Dor-030245	Dipodomys ordii	83.62	4.00e-55	204.00
IUUC-Dse-031428	Dothistroma septosporum	56.90	5.00e-37	144.00
IUUC-Dme-031813	Drosophila melanogaster	85.34	4.00e-56	207.00
IUUC-Ete-032671	Echinops telfairi	82.76	8.00e-55	203.00
IUUC-Eca-033464	Equus caballus	78.45	7.00e-52	194.00
IUUC-Eeu-035131	Erinaceus europaeus	83.72	5.00e-39	150.00
IUUC-Fca-036493	Felis catus	83.62	3.00e-55	205.00
IUUC-Fal-037143	Ficedula albicollis	77.31	7.00e-52	194.00
IUUC-Fox-037846	Fusarium oxysporum	56.90	1.00e-36	143.00
IUUC-Fso-038134	Fusarium solani	56.90	7.00e-37	144.00
IUUC-Gmo-039671	Gadus morhua	82.76	4.00e-54	201.00
IUUC-Ggr-039770	Gaeumannomyces graminis	56.03	6.00e-36	140.00
IUUC-Gga-040257	Gallus gallus	82.91	2.00e-55	206.00
IUUC-Gac-042507	Gasterosteus aculeatus	82.05	2.00e-54	202.00
IUUC-Gma-043572	Glycine max	58.04	6.00e-29	117.00
IUUC-Ggo-044860	Gorilla gorilla	83.62	4.00e-55	204.00
IUUC-Hsa-045905	Homo sapiens	83.62	4.00e-55	204.00
IUUC-Hvu-047062	Hordeum vulgare	54.31	2.00e-35	139.00
IUUC-Itr-048405	Ictidomys tridecemlineatus	83.62	4.00e-55	204.00
IUUC-Kpa-049124	Komagataella pastoris	50.86	4.00e-33	131.00
IUUC-Lch-049798	Latimeria chalumnae	73.28	9.00e-50	186.00
IUUC-Lpe-051292	Leersia perrieri	54.78	9.00e-36	140.00
IUUC-Loc-052290	Lepisosteus oculatus	82.35	3.00e-55	205.00
IUUC-Laf-054203	Loxodonta africana	83.62	4.00e-55	204.00
IUUC-Mcc-055307	Macaca mulatta	83.62	4.00e-55	204.00
IUUC-Meu-056010	Macropus eugenii	78.45	7.00e-52	194.00
IUUC-Mor-057276	Magnaporthe oryzae	54.47	6.00e-36	140.00
IUUC-Mpo-057469	Magnaporthe poae	55.00	9.00e-36	140.00
IUUC-Mtr-058417	Medicago truncatula	57.39	5.00e-29	118.00
IUUC-Mla-059098	Melampsora laricipopulina	56.90	1.00e-37	146.00
IUUC-Mga-060108	Meleagris gallopavo	76.67	3.00e-52	194.00
IUUC-Mvi-060496	Microbotryum violaceum	56.64	5.00e-37	144.00
IUUC-Mmr-061776	Microcebus murinus	83.62	4.00e-55	204.00
IUUC-Mdo-062279	Monodelphis domestica	78.45	5.00e-52	194.00
IUUC-Mmu-064157	Mus musculus	83.62	4.00e-55	204.00
IUUC-Mac-065529	Musa acuminata	54.31	6.00e-30	121.00
IUUC-Mpu-066028	Mustela putorius furo	83.62	3.00e-55	205.00
IUUC-Mlu-067166	Myotis lucifugus	83.62	4.00e-55	204.00
IUUC-Nfi-068367	Neosartorya fischeri	56.90	6.00e-37	144.00
IUUC-Ncr-068894	Neurospora crassa	56.90	6.00e-37	144.00
IUUC-Nle-069220	Nomascus leucogenys	83.62	4.00e-55	204.00
IUUC-Opr-070777	Ochotona princeps	83.62	4.00e-55	204.00
IUUC-Ont-072343	Oreochromis niloticus	57.76	8.00e-38	147.00
IUUC-Oan-073612	Ornithorhynchus anatinus	83.72	8.00e-40	152.00
IUUC-Ocu-074148	Oryctolagus cuniculus	83.62	4.00e-55	204.00
IUUC-Oba-075722	Oryza barthii	53.91	1.00e-35	139.00
IUUC-Obr-076830	Oryza brachyantha	54.78	4.00e-35	138.00
IUUC-Ogl-077551	Oryza glaberrima	53.91	1.00e-35	139.00
IUUC-Ogu-078499	Oryza glumaepatula	53.91	1.00e-35	139.00
IUUC-Oin-079272	Oryza indica	53.91	4.00e-35	138.00
IUUC-Olo-080412	Oryza longistaminata	53.91	7.00e-35	137.00
IUUC-Ome-081990	Oryza meridionalis	53.91	4.00e-35	138.00
IUUC-Oni-082665	Oryza nivara	53.91	4.00e-35	138.00
IUUC-Opu-083501	Oryza punctata	54.78	4.00e-35	138.00
IUUC-Oru-084425	Oryza rufipogon	53.91	4.00e-35	138.00
IUUC-Osa-085618	Oryza sativa	53.91	4.00e-35	138.00
IUUC-Ola-086391	Oryzias latipes	72.81	2.00e-43	166.00
IUUC-Olu-087892	Ostreococcus lucimarinus	58.12	1.00e-37	146.00
IUUC-Oga-088312	Otolemur garnettii	83.62	4.00e-55	204.00
IUUC-Oar-089989	Ovis aries	83.62	4.00e-55	204.00
IUUC-Ptr-091108	Pan troglodytes	83.62	4.00e-55	204.00
IUUC-Pan-092269	Papio anubis	57.76	7.00e-38	147.00
IUUC-Psi-093055	Pelodiscus sinensis	78.45	7.00e-52	194.00
IUUC-Pma-094337	Petromyzon marinus	56.03	5.00e-40	154.00
IUUC-Pno-095035	Phaeosphaeria nodorum	56.90	1.00e-36	143.00
IUUC-Ppa-095257	Physcomitrella patens	58.62	7.00e-38	147.00
IUUC-Pfo-096947	Poecilia formosa	65.26	4.00e-32	128.00
IUUC-Pab-097660	Pongo abelii	83.62	4.00e-55	204.00
IUUC-Pop-100069	Populus trichocarpa	58.26	1.00e-30	123.00
IUUC-Pca-100230	Procavia capensis	83.62	4.00e-55	204.00
IUUC-Ppe-101863	Prunus persica	56.78	1.00e-29	120.00
IUUC-Pva-103103	Pteropus vampyrus	78.45	7.00e-52	194.00
IUUC-Pte-104230	Pyrenophora teres	56.90	1.00e-36	143.00
IUUC-Rno-105497	Rattus norvegicus	83.62	4.00e-55	204.00
IUUC-Sce-106150	Saccharomyces cerevisiae	53.45	2.00e-34	135.00
IUUC-Sha-106656	Sarcophilus harrisii	83.62	4.00e-55	204.00
IUUC-Sja-107857	Schizosaccharomyces japonicus	54.62	3.00e-36	142.00
IUUC-Spo-108156	Schizosaccharomyces pombe	55.17	6.00e-31	124.00
IUUC-Ssl-108578	Sclerotinia sclerotiorum	56.20	1.00e-37	146.00
IUUC-Smo-109082	Selaginella moellendorffii	57.39	3.00e-37	145.00
IUUC-Sit-110465	Setaria italica	55.17	1.00e-35	139.00
IUUC-Sly-111488	Solanum lycopersicum	55.17	8.00e-31	124.00
IUUC-Stu-112559	Solanum tuberosum	55.17	8.00e-31	124.00
IUUC-Sar-113670	Sorex araneus	75.86	5.00e-50	187.00
IUUC-Sbi-114782	Sorghum bicolor	55.17	5.00e-36	141.00
IUUC-Sre-114964	Sporisorium reilianum	57.76	7.00e-39	150.00
IUUC-Ssc-116182	Sus scrofa	83.62	4.00e-55	204.00
IUUC-Tgu-116669	Taeniopygia guttata	78.45	7.00e-52	194.00
IUUC-Tru-118632	Takifugu rubripes	82.05	2.00e-54	203.00
IUUC-Tsy-118919	Tarsius syrichta	78.45	7.00e-52	194.00
IUUC-Tni-120706	Tetraodon nigroviridis	56.10	6.00e-38	147.00
IUUC-Tca-121335	Theobroma cacao	56.12	1.00e-30	124.00
IUUC-Tre-122077	Trichoderma reesei	56.90	6.00e-37	144.00
IUUC-Tvi-122400	Trichoderma virens	56.90	6.00e-37	144.00
IUUC-Tae-122697	Triticum aestivum	54.31	1.00e-34	137.00
IUUC-Tur-126158	Triticum urartu	53.45	2.00e-34	136.00
IUUC-Tme-126955	Tuber melanosporum	56.78	9.00e-37	144.00
IUUC-Tbe-128099	Tupaia belangeri	59.48	1.00e-35	139.00
IUUC-Ttr-128712	Tursiops truncatus	78.45	7.00e-52	194.00
IUUC-Uma-129435	Ustilago maydis	57.76	8.00e-39	150.00
IUUC-Vda-129807	Verticillium dahliae	56.90	5.00e-37	144.00
IUUC-Vpa-130227	Vicugna pacos	83.72	7.00e-40	152.00
IUUC-Vvi-131213	Vitis vinifera	53.39	5.00e-31	124.00
IUUC-Xtr-132183	Xenopus tropicalis	78.45	7.00e-52	194.00
IUUC-Xma-133400	Xiphophorus maculatus	82.05	2.00e-54	202.00
IUUC-Yli-134327	Yarrowia lipolytica	55.17	3.00e-28	115.00
IUUC-Zma-135270	Zea mays	54.78	2.00e-35	139.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence