iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Family	Identity	E-Value	Score	Source Orthology
UBD/ZnF/UBZ	41.24	3.00e-92	337.00	IUUC-Hsa-046608
UBD/ZnF/UBZ	25.75	2.00e-20	95.50	IUUC-Sce-106137
UBD/Alpha-Helix/UBM	30.96	5.00e-31	133.00	IUUC-Xtr-132975

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Arabidopsis thaliana

Functional Description
(View)

Error-free DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis (TLS), where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers and confers resistance to ultraviolet light. Depending on the context, it inserts the correct base, but may cause base transitions and transversions. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci. Exhibits cyclobutane dimer nonmutagenic bypass activity in vitro.

Protein Sequence
(Fasta)

MPVARPEASD ARVIAHVDMD CFYVQVEQRK QPELRGLPSA VVQYNEWQGG GLIAVSYEAR 60
KCGVKRSMRG DEAKAACPQI QLVQVPVARG KADLNLYRSA GSEVVSILAK SGKCERASID 120

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Nucleotide Sequence
(Fasta)

TATTTTCGCG CGCTATTCAT CAGTCATCAT CCCCAAGAAA CCCCTCTTTC GGTGGTAAAA 60
ACTCTCTCTC TCTCTCTCTC TCTCCCTCTG ATTTCTGCGG AGATTTCTGA AATAGAAATG 120

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Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0235--DNA replication
KW-0237--DNA synthesis
KW-0238--DNA-binding
KW-0239--DNA-directed DNA polymerase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0515--Mutator protein
KW-0548--Nucleotidyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0704--Schiff base
KW-0808--Transferase

Interpro

IPR017061--DNA_pol_eta/kappa
IPR017961--DNA_pol_Y-fam_little_finger
IPR001126--UmuC

PROSITE

PS50173--UMUC

Pfam

PF00817--IMS
PF11799--IMS_C

Gene Ontology

GO:0005634--C:nucleus
GO:0003684--F:damaged DNA binding
GO:0003887--F:DNA-directed DNA polymerase activity
GO:0046872--F:metal ion binding
GO:0006260--P:DNA replication
GO:0042276--P:error-prone translesion synthesis
GO:0010224--P:response to UV-B
GO:0009650--P:UV protection

KEGG

ath:AT5G44740

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000901	Aegilops tauschii	72.59	7.00e-136	476.00
IUUC-Aml-001521	Ailuropoda melanoleuca	41.35	1.00e-92	333.00
IUUC-Atr-002484	Amborella trichopoda	70.93	0.00e+00	687.00
IUUC-Apl-003696	Anas platyrhynchos	35.89	4.00e-49	189.00
IUUC-Aca-005058	Anolis carolinensis	42.46	2.00e-88	319.00
IUUC-Aly-006400	Arabidopsis lyrata	92.71	0.00e+00	1269.00
IUUC-Ago-007927	Ashbya gossypii	26.93	3.00e-18	86.30
IUUC-Acl-008115	Aspergillus clavatus	30.07	1.00e-42	167.00
IUUC-Afl-008392	Aspergillus flavus	30.62	8.00e-43	167.00
IUUC-Afu-008955	Aspergillus fumigatus	30.81	4.00e-41	162.00
IUUC-Ani-009140	Aspergillus nidulans	31.71	1.00e-40	160.00
IUUC-Ang-009579	Aspergillus niger	31.37	5.00e-42	165.00
IUUC-Aor-010144	Aspergillus oryzae	29.53	2.00e-42	166.00
IUUC-Ate-010589	Aspergillus terreus	31.39	2.00e-41	164.00
IUUC-Ame-010824	Astyanax mexicanus	42.83	4.00e-97	348.00
IUUC-Bgr-012128	Blumeria graminis	32.90	4.00e-44	172.00
IUUC-Bta-013570	Bos taurus	39.87	4.00e-78	285.00
IUUC-Bci-013638	Botrytis cinerea	29.15	2.00e-42	166.00
IUUC-Bdi-014945	Brachypodium distachyon	52.65	0.00e+00	642.00
IUUC-Bol-016267	Brassica oleracea	83.98	0.00e+00	1138.00
IUUC-Bra-017812	Brassica rapa	81.73	0.00e+00	1141.00
IUUC-Cel-018475	Caenorhabditis elegans	34.82	1.00e-61	230.00
IUUC-Cja-019783	Callithrix jacchus	36.26	3.00e-60	226.00
IUUC-Cfa-021182	Canis familiaris	45.27	1.00e-87	316.00
IUUC-Cpo-021579	Cavia porcellus	41.63	3.00e-83	302.00
IUUC-Cre-022939	Chlamydomonas reinhardtii	31.74	3.00e-26	113.00
IUUC-Csa-023918	Chlorocebus sabaeus	41.21	4.00e-86	311.00
IUUC-Cho-024661	Choloepus hoffmanni	44.28	1.00e-84	306.00
IUUC-Cin-025717	Ciona intestinalis	44.60	2.00e-66	245.00
IUUC-Csv-026134	Ciona savignyi	62.90	1.00e-43	168.00
IUUC-Cgl-026574	Colletotrichum gloeosporioides	29.93	1.00e-40	160.00
IUUC-Cne-026787	Cryptococcus neoformans	29.50	5.00e-31	129.00
IUUC-Cme-027172	Cyanidioschyzon merolae	28.42	3.00e-41	162.00
IUUC-Dre-028594	Danio rerio	43.70	9.00e-92	330.00
IUUC-Dno-029221	Dasypus novemcinctus	41.84	9.00e-87	313.00
IUUC-Dor-030818	Dipodomys ordii	44.91	5.00e-45	175.00
IUUC-Dse-031223	Dothistroma septosporum	32.43	3.00e-42	165.00
IUUC-Dme-031727	Drosophila melanogaster	38.34	7.00e-86	311.00
IUUC-Ete-033036	Echinops telfairi	40.93	1.00e-83	303.00
IUUC-Eca-034307	Equus caballus	41.14	6.00e-86	311.00
IUUC-Eeu-035197	Erinaceus europaeus	55.28	7.00e-32	131.00
IUUC-Fca-035449	Felis catus	40.89	6.00e-85	307.00
IUUC-Fal-036901	Ficedula albicollis	46.05	1.00e-42	167.00
IUUC-Fox-037911	Fusarium oxysporum	32.39	1.00e-42	167.00
IUUC-Fso-038351	Fusarium solani	30.77	3.00e-39	156.00
IUUC-Gmo-039408	Gadus morhua	40.77	2.00e-95	342.00
IUUC-Ggr-039856	Gaeumannomyces graminis	29.27	2.00e-36	147.00
IUUC-Gga-040686	Gallus gallus	45.89	6.00e-85	308.00
IUUC-Gac-042191	Gasterosteus aculeatus	40.86	1.00e-92	333.00
IUUC-Gma-043642	Glycine max	57.91	0.00e+00	766.00
IUUC-Ggo-045651	Gorilla gorilla	29.26	1.00e-35	144.00
IUUC-Hsa-046608	Homo sapiens	44.44	3.00e-85	308.00
IUUC-Hvu-047627	Hordeum vulgare	53.83	0.00e+00	647.00
IUUC-Itr-048689	Ictidomys tridecemlineatus	40.25	7.00e-83	301.00
IUUC-Kpa-049113	Komagataella pastoris	27.59	1.00e-25	110.00
IUUC-Lch-049987	Latimeria chalumnae	46.98	2.00e-46	180.00
IUUC-Lpe-051542	Leersia perrieri	55.17	0.00e+00	661.00
IUUC-Loc-052036	Lepisosteus oculatus	37.44	3.00e-73	269.00
IUUC-Lma-053317	Leptosphaeria maculans	32.21	3.00e-40	159.00
IUUC-Laf-053792	Loxodonta africana	42.11	9.00e-87	313.00
IUUC-Mcc-055144	Macaca mulatta	44.58	5.00e-85	307.00
IUUC-Meu-056553	Macropus eugenii	36.84	4.00e-49	187.00
IUUC-Mor-057207	Magnaporthe oryzae	30.17	1.00e-41	164.00
IUUC-Mpo-057497	Magnaporthe poae	29.11	6.00e-40	158.00
IUUC-Mtr-058741	Medicago truncatula	59.14	0.00e+00	773.00
IUUC-Mla-059160	Melampsora laricipopulina	29.59	7.00e-41	161.00
IUUC-Mga-059487	Meleagris gallopavo	46.85	2.00e-46	179.00
IUUC-Mvi-060508	Microbotryum violaceum	30.58	3.00e-40	159.00
IUUC-Mmr-061610	Microcebus murinus	40.71	7.00e-85	307.00
IUUC-Mdo-061810	Monodelphis domestica	43.53	1.00e-81	296.00
IUUC-Mmu-063400	Mus musculus	40.72	9.00e-84	303.00
IUUC-Mac-064894	Musa acuminata	55.54	0.00e+00	705.00
IUUC-Mpu-066225	Mustela putorius furo	38.82	9.00e-68	250.00
IUUC-Mlu-067052	Myotis lucifugus	41.05	3.00e-84	305.00
IUUC-Nfi-068296	Neosartorya fischeri	28.03	7.00e-41	161.00
IUUC-Ncr-068957	Neurospora crassa	33.42	3.00e-45	176.00
IUUC-Nle-069730	Nomascus leucogenys	38.92	7.00e-68	251.00
IUUC-Opr-070411	Ochotona princeps	37.46	7.00e-43	168.00
IUUC-Ont-071788	Oreochromis niloticus	41.52	2.00e-94	339.00
IUUC-Oan-073017	Ornithorhynchus anatinus	43.42	4.00e-83	301.00
IUUC-Ocu-074059	Oryctolagus cuniculus	44.09	4.00e-81	295.00
IUUC-Oba-075708	Oryza barthii	56.95	0.00e+00	660.00
IUUC-Obr-076475	Oryza brachyantha	53.79	0.00e+00	659.00
IUUC-Ogl-077868	Oryza glaberrima	56.37	0.00e+00	667.00
IUUC-Ogu-078157	Oryza glumaepatula	56.95	0.00e+00	659.00
IUUC-Oin-079707	Oryza indica	71.75	3.00e-142	498.00
IUUC-Olo-080763	Oryza longistaminata	63.73	3.00e-169	587.00
IUUC-Oni-082290	Oryza nivara	55.62	0.00e+00	654.00
IUUC-Opu-083795	Oryza punctata	56.12	0.00e+00	672.00
IUUC-Oru-085178	Oryza rufipogon	57.10	0.00e+00	662.00
IUUC-Osa-086176	Oryza sativa	56.37	0.00e+00	666.00
IUUC-Ola-087517	Oryzias latipes	41.70	7.00e-95	340.00
IUUC-Olu-087640	Ostreococcus lucimarinus	38.70	3.00e-83	301.00
IUUC-Oga-088142	Otolemur garnettii	41.63	1.00e-86	313.00
IUUC-Oar-089974	Ovis aries	39.41	2.00e-78	286.00
IUUC-Ptr-090591	Pan troglodytes	44.44	3.00e-85	308.00
IUUC-Pan-091688	Papio anubis	41.21	4.00e-86	311.00
IUUC-Psi-092952	Pelodiscus sinensis	35.29	5.00e-54	204.00
IUUC-Pma-094381	Petromyzon marinus	27.39	1.00e-18	87.80
IUUC-Pno-094892	Phaeosphaeria nodorum	33.72	4.00e-38	152.00
IUUC-Ppa-095504	Physcomitrella patens	53.77	2.00e-139	488.00
IUUC-Pfo-096999	Poecilia formosa	41.92	2.00e-94	340.00
IUUC-Pab-098195	Pongo abelii	36.63	2.00e-33	136.00
IUUC-Pop-099023	Populus trichocarpa	72.45	0.00e+00	739.00
IUUC-Pca-100689	Procavia capensis	35.48	7.00e-64	238.00
IUUC-Ppe-101947	Prunus persica	62.74	0.00e+00	823.00
IUUC-Pva-102392	Pteropus vampyrus	41.48	3.00e-84	305.00
IUUC-Pgr-103588	Puccinia graminis	29.72	2.00e-41	163.00
IUUC-Ptt-103860	Puccinia triticina	32.99	2.00e-39	156.00
IUUC-Pte-104326	Pyrenophora teres	31.46	5.00e-40	158.00
IUUC-Pyt-104573	Pyrenophora triticirepentis	31.97	3.00e-39	156.00
IUUC-Rno-105209	Rattus norvegicus	42.27	4.00e-85	308.00
IUUC-Sce-106137	Saccharomyces cerevisiae	25.82	5.00e-21	95.50
IUUC-Sha-106467	Sarcophilus harrisii	43.64	4.00e-85	308.00
IUUC-Sja-107701	Schizosaccharomyces japonicus	29.95	2.00e-32	134.00
IUUC-Spo-108204	Schizosaccharomyces pombe	29.55	3.00e-41	163.00
IUUC-Ssl-108431	Sclerotinia sclerotiorum	29.78	2.00e-32	133.00
IUUC-Smo-109141	Selaginella moellendorffii	61.31	9.00e-149	519.00
IUUC-Sit-110280	Setaria italica	56.09	0.00e+00	702.00
IUUC-Sly-111756	Solanum lycopersicum	56.73	0.00e+00	743.00
IUUC-Stu-112504	Solanum tuberosum	71.56	7.00e-134	469.00
IUUC-Sar-113088	Sorex araneus	36.82	2.00e-64	239.00
IUUC-Sbi-114731	Sorghum bicolor	55.38	0.00e+00	693.00
IUUC-Sre-115144	Sporisorium reilianum	39.06	5.00e-20	92.80
IUUC-Ssc-115300	Sus scrofa	39.83	2.00e-82	299.00
IUUC-Tgu-117128	Taeniopygia guttata	47.03	6.00e-43	166.00
IUUC-Tru-118550	Takifugu rubripes	42.58	2.00e-93	336.00
IUUC-Tsy-119086	Tarsius syrichta	30.97	2.00e-33	137.00
IUUC-Tni-120908	Tetraodon nigroviridis	41.08	2.00e-92	333.00
IUUC-Tca-121449	Theobroma cacao	59.86	0.00e+00	813.00
IUUC-Tre-122135	Trichoderma reesei	28.82	2.00e-38	153.00
IUUC-Tvi-122467	Trichoderma virens	30.83	9.00e-42	164.00
IUUC-Tae-125677	Triticum aestivum	53.09	0.00e+00	639.00
IUUC-Tur-126600	Triticum urartu	67.91	1.00e-166	579.00
IUUC-Tme-126967	Tuber melanosporum	34.18	8.00e-47	181.00
IUUC-Tbe-127444	Tupaia belangeri	41.25	2.00e-83	302.00
IUUC-Ttr-128797	Tursiops truncatus	39.26	9.00e-78	284.00
IUUC-Uma-129609	Ustilago maydis	34.59	3.00e-19	90.10
IUUC-Vda-130004	Verticillium dahliae	31.35	1.00e-42	167.00
IUUC-Vpa-130029	Vicugna pacos	36.22	3.00e-47	182.00
IUUC-Vvi-131117	Vitis vinifera	60.92	0.00e+00	743.00
IUUC-Xtr-132975	Xenopus tropicalis	30.96	2.00e-32	133.00
IUUC-Xma-133279	Xiphophorus maculatus	42.83	5.00e-96	344.00
IUUC-Yli-134477	Yarrowia lipolytica	29.32	4.00e-29	122.00
IUUC-Zma-135837	Zea mays	54.70	0.00e+00	691.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence