iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/ZnF/UBZ	UBZ	16357261; 17251197; 17304240; 23076824

Classification

Family	E-value	Score	Start	End
UBD/ZnF/UBZ	4.10e-07	31.8	632	655

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/UBZ

   S: 1    llvCPvCqkmvdqtdfeeHlDeCl 24
           +++C++C++ v+++d++eH+D+++
   Q: 632  QVPCEKCGSLVPVWDMPEHMDYHF 655
           699********************8 PP

Organism

Homo sapiens

Functional Description
(View)

DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:24449906). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (PubMed:24449906). Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124, PubMed:11743006). Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes (PubMed:11376341, PubMed:14734526). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue. This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis (PubMed:14630940). Targets POLI to replication foci (PubMed:12606586).

Protein Sequence
(Fasta)

MATGQDRVVA LVDMDCFFVQ VEQRQNPHLR NKPCAVVQYK SWKGGGIIAV SYEARAFGVT 60
RSMWADDAKK LCPDLLLAQV RESRGKANLT KYREASVEVM EIMSRFAVIE RASIDEAYVD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACGGCCCTT CGCAGCGGGC GCGCTGTCAG ACCTCAGTCT GGCGGCTGCA TTGCTGGGCG 60
CGCCGCTCTC GTCTGATCCC TGCTGGGGAC GGTTGCCCGG GCAGGATCCT TTACGATCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0227--DNA damage
KW-0234--DNA repair
KW-0235--DNA replication
KW-0237--DNA synthesis
KW-0238--DNA-binding
KW-0239--DNA-directed DNA polymerase
KW-1017--Isopeptide bond
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0515--Mutator protein
KW-0548--Nucleotidyltransferase
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0704--Schiff base
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0857--Xeroderma pigmentosum

Interpro

IPR017061--DNA_pol_eta/kappa
IPR017961--DNA_pol_Y-fam_little_finger
IPR001126--UmuC

PROSITE

PS50173--UMUC

Pfam

PF00817--IMS
PF11799--IMS_C

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0003684--F:damaged DNA binding
GO:0003887--F:DNA-directed DNA polymerase activity
GO:0046872--F:metal ion binding
GO:0071494--P:cellular response to UV-C
GO:0006281--P:DNA repair
GO:0006260--P:DNA replication
GO:0000731--P:DNA synthesis involved in DNA repair
GO:0070987--P:error-free translesion synthesis
GO:0006290--P:pyrimidine dimer repair
GO:0006282--P:regulation of DNA repair
GO:0010225--P:response to UV-C
GO:0019985--P:translesion synthesis

KEGG

hsa:5429

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000901	Aegilops tauschii	44.38	2.00e-77	282.00
IUUC-Aml-001521	Ailuropoda melanoleuca	85.83	0.00e+00	1202.00
IUUC-Atr-002484	Amborella trichopoda	41.04	5.00e-92	332.00
IUUC-Apl-003696	Anas platyrhynchos	47.82	4.00e-113	402.00
IUUC-Aca-005058	Anolis carolinensis	54.60	0.00e+00	717.00
IUUC-Aly-006400	Arabidopsis lyrata	41.25	1.00e-86	313.00
IUUC-Ath-007504	Arabidopsis thaliana	41.24	2.00e-93	337.00
IUUC-Ago-007927	Ashbya gossypii	25.06	3.00e-24	106.00
IUUC-Acl-008115	Aspergillus clavatus	30.71	2.00e-43	170.00
IUUC-Afl-008392	Aspergillus flavus	31.99	3.00e-47	183.00
IUUC-Afu-008955	Aspergillus fumigatus	30.48	1.00e-43	171.00
IUUC-Ani-009140	Aspergillus nidulans	29.57	2.00e-42	167.00
IUUC-Ang-009579	Aspergillus niger	31.47	8.00e-42	165.00
IUUC-Aor-010144	Aspergillus oryzae	31.74	1.00e-46	181.00
IUUC-Ate-010589	Aspergillus terreus	32.49	5.00e-48	186.00
IUUC-Ame-010824	Astyanax mexicanus	52.23	0.00e+00	658.00
IUUC-Bgr-012128	Blumeria graminis	30.32	8.00e-43	168.00
IUUC-Bta-013570	Bos taurus	82.61	0.00e+00	1103.00
IUUC-Bci-013638	Botrytis cinerea	30.91	7.00e-46	179.00
IUUC-Bdi-014945	Brachypodium distachyon	43.21	7.00e-90	325.00
IUUC-Bol-016267	Brassica oleracea	43.10	6.00e-90	325.00
IUUC-Bra-017812	Brassica rapa	42.32	2.00e-87	317.00
IUUC-Cel-018475	Caenorhabditis elegans	36.11	1.00e-74	273.00
IUUC-Cja-019783	Callithrix jacchus	92.93	0.00e+00	1165.00
IUUC-Cfa-021182	Canis familiaris	86.87	0.00e+00	1135.00
IUUC-Cpo-021579	Cavia porcellus	82.35	0.00e+00	1129.00
IUUC-Csa-023918	Chlorocebus sabaeus	96.63	0.00e+00	1316.00
IUUC-Cho-024661	Choloepus hoffmanni	86.13	0.00e+00	1199.00
IUUC-Cin-025717	Ciona intestinalis	50.68	4.00e-79	288.00
IUUC-Csv-026134	Ciona savignyi	55.77	1.00e-46	178.00
IUUC-Cgl-026574	Colletotrichum gloeosporioides	28.99	3.00e-34	140.00
IUUC-Cne-026787	Cryptococcus neoformans	28.10	6.00e-31	129.00
IUUC-Cme-027172	Cyanidioschyzon merolae	27.87	6.00e-29	122.00
IUUC-Dre-028594	Danio rerio	48.27	4.00e-178	618.00
IUUC-Dno-029221	Dasypus novemcinctus	86.29	0.00e+00	1182.00
IUUC-Dor-030818	Dipodomys ordii	90.00	2.00e-119	423.00
IUUC-Dse-031223	Dothistroma septosporum	29.09	5.00e-37	149.00
IUUC-Dme-031727	Drosophila melanogaster	39.75	2.00e-100	360.00
IUUC-Ete-033036	Echinops telfairi	79.47	0.00e+00	1052.00
IUUC-Eca-034307	Equus caballus	83.47	0.00e+00	1063.00
IUUC-Eeu-035197	Erinaceus europaeus	72.79	4.00e-158	551.00
IUUC-Fca-035449	Felis catus	87.38	0.00e+00	1141.00
IUUC-Fal-036901	Ficedula albicollis	59.94	1.00e-96	347.00
IUUC-Fox-037911	Fusarium oxysporum	29.85	4.00e-42	166.00
IUUC-Fso-038351	Fusarium solani	30.05	1.00e-37	151.00
IUUC-Gmo-039408	Gadus morhua	49.38	0.00e+00	632.00
IUUC-Ggr-039856	Gaeumannomyces graminis	30.23	5.00e-36	146.00
IUUC-Gga-040686	Gallus gallus	52.98	1.00e-171	596.00
IUUC-Gac-042191	Gasterosteus aculeatus	61.09	3.00e-175	608.00
IUUC-Gma-043642	Glycine max	41.76	8.00e-90	325.00
IUUC-Hvu-047627	Hordeum vulgare	41.20	1.00e-90	327.00
IUUC-Itr-048689	Ictidomys tridecemlineatus	85.24	0.00e+00	1171.00
IUUC-Kpa-049113	Komagataella pastoris	25.91	2.00e-25	110.00
IUUC-Lch-049987	Latimeria chalumnae	70.40	9.00e-91	328.00
IUUC-Lpe-051542	Leersia perrieri	41.05	6.00e-91	328.00
IUUC-Loc-052036	Lepisosteus oculatus	50.44	3.00e-167	582.00
IUUC-Lma-053317	Leptosphaeria maculans	30.61	5.00e-42	166.00
IUUC-Laf-053792	Loxodonta africana	84.11	0.00e+00	1165.00
IUUC-Mcc-055144	Macaca mulatta	98.31	0.00e+00	820.00
IUUC-Meu-056553	Macropus eugenii	75.27	4.00e-150	524.00
IUUC-Mor-057207	Magnaporthe oryzae	28.76	5.00e-37	149.00
IUUC-Mpo-057497	Magnaporthe poae	29.66	4.00e-37	150.00
IUUC-Mtr-058741	Medicago truncatula	43.89	5.00e-94	338.00
IUUC-Mla-059160	Melampsora laricipopulina	30.67	2.00e-41	163.00
IUUC-Mga-059487	Meleagris gallopavo	47.23	1.00e-126	446.00
IUUC-Mvi-060508	Microbotryum violaceum	29.52	6.00e-40	159.00
IUUC-Mmr-061610	Microcebus murinus	88.08	0.00e+00	1209.00
IUUC-Mdo-061810	Monodelphis domestica	68.36	0.00e+00	883.00
IUUC-Mmu-063400	Mus musculus	78.58	0.00e+00	987.00
IUUC-Mac-064894	Musa acuminata	39.69	2.00e-89	323.00
IUUC-Mpu-066225	Mustela putorius furo	85.10	0.00e+00	1083.00
IUUC-Mlu-067052	Myotis lucifugus	88.08	0.00e+00	1172.00
IUUC-Nfi-068296	Neosartorya fischeri	29.97	3.00e-42	167.00
IUUC-Ncr-068957	Neurospora crassa	31.83	4.00e-45	176.00
IUUC-Nle-069730	Nomascus leucogenys	94.25	0.00e+00	1237.00
IUUC-Opr-070411	Ochotona princeps	69.16	0.00e+00	652.00
IUUC-Ont-071788	Oreochromis niloticus	64.78	0.00e+00	627.00
IUUC-Oan-073017	Ornithorhynchus anatinus	69.70	0.00e+00	738.00
IUUC-Ocu-074059	Oryctolagus cuniculus	76.30	0.00e+00	979.00
IUUC-Oba-075708	Oryza barthii	41.27	2.00e-91	330.00
IUUC-Obr-076475	Oryza brachyantha	40.51	2.00e-89	323.00
IUUC-Ogl-077868	Oryza glaberrima	41.27	2.00e-91	330.00
IUUC-Ogu-078157	Oryza glumaepatula	41.45	2.00e-91	330.00
IUUC-Oin-079707	Oryza indica	45.01	2.00e-78	286.00
IUUC-Olo-080763	Oryza longistaminata	44.82	1.00e-88	320.00
IUUC-Oni-082290	Oryza nivara	40.29	1.00e-89	323.00
IUUC-Opu-083795	Oryza punctata	41.31	2.00e-90	326.00
IUUC-Oru-085178	Oryza rufipogon	40.89	1.00e-91	330.00
IUUC-Osa-086176	Oryza sativa	41.10	9.00e-92	331.00
IUUC-Ola-087517	Oryzias latipes	51.64	0.00e+00	666.00
IUUC-Olu-087640	Ostreococcus lucimarinus	32.30	3.00e-56	213.00
IUUC-Oga-088142	Otolemur garnettii	85.88	0.00e+00	1164.00
IUUC-Oar-089974	Ovis aries	82.47	0.00e+00	1062.00
IUUC-Ptr-090591	Pan troglodytes	99.72	0.00e+00	1308.00
IUUC-Pan-091688	Papio anubis	96.77	0.00e+00	1318.00
IUUC-Psi-092952	Pelodiscus sinensis	51.87	2.00e-167	582.00
IUUC-Pma-094704	Petromyzon marinus	35.60	8.00e-41	161.00
IUUC-Pno-094892	Phaeosphaeria nodorum	30.58	4.00e-39	156.00
IUUC-Ppa-095504	Physcomitrella patens	45.50	2.00e-84	306.00
IUUC-Pfo-096999	Poecilia formosa	64.60	6.00e-171	594.00
IUUC-Pab-098195	Pongo abelii	97.57	0.00e+00	880.00
IUUC-Pop-099023	Populus trichocarpa	41.92	4.00e-90	325.00
IUUC-Pca-100689	Procavia capensis	79.25	0.00e+00	848.00
IUUC-Ppe-101947	Prunus persica	41.94	1.00e-91	330.00
IUUC-Pva-102392	Pteropus vampyrus	87.38	0.00e+00	1162.00
IUUC-Pgr-103588	Puccinia graminis	32.66	6.00e-44	172.00
IUUC-Ptt-103860	Puccinia triticina	31.01	2.00e-36	147.00
IUUC-Pte-104326	Pyrenophora teres	29.60	5.00e-40	159.00
IUUC-Pyt-104573	Pyrenophora triticirepentis	29.55	8.00e-40	158.00
IUUC-Rno-105209	Rattus norvegicus	77.28	0.00e+00	1045.00
IUUC-Sce-106137	Saccharomyces cerevisiae	23.11	6.00e-22	99.40
IUUC-Sha-106467	Sarcophilus harrisii	69.53	0.00e+00	904.00
IUUC-Sja-107701	Schizosaccharomyces japonicus	30.05	1.00e-33	139.00
IUUC-Spo-108204	Schizosaccharomyces pombe	30.32	7.00e-39	155.00
IUUC-Ssl-108431	Sclerotinia sclerotiorum	31.34	7.00e-38	152.00
IUUC-Smo-109015	Selaginella moellendorffii	46.03	1.00e-78	286.00
IUUC-Sit-110280	Setaria italica	42.60	2.00e-94	340.00
IUUC-Sly-111756	Solanum lycopersicum	40.98	2.00e-90	326.00
IUUC-Stu-112504	Solanum tuberosum	42.90	1.00e-64	239.00
IUUC-Sar-113088	Sorex araneus	69.85	0.00e+00	905.00
IUUC-Sbi-114731	Sorghum bicolor	42.60	3.00e-94	339.00
IUUC-Sre-115144	Sporisorium reilianum	35.29	5.00e-22	100.00
IUUC-Ssc-115300	Sus scrofa	81.63	0.00e+00	1092.00
IUUC-Tgu-117128	Taeniopygia guttata	68.16	5.00e-86	310.00
IUUC-Tru-118550	Takifugu rubripes	52.05	0.00e+00	671.00
IUUC-Tni-120908	Tetraodon nigroviridis	50.88	0.00e+00	668.00
IUUC-Tca-121449	Theobroma cacao	44.53	5.00e-91	328.00
IUUC-Tre-122135	Trichoderma reesei	30.59	5.00e-39	155.00
IUUC-Tvi-122467	Trichoderma virens	30.32	9.00e-40	158.00
IUUC-Tae-125677	Triticum aestivum	37.43	6.00e-90	325.00
IUUC-Tur-126600	Triticum urartu	40.50	1.00e-82	301.00
IUUC-Tme-126967	Tuber melanosporum	33.60	4.00e-45	176.00
IUUC-Tbe-127444	Tupaia belangeri	84.99	0.00e+00	1162.00
IUUC-Ttr-128797	Tursiops truncatus	85.41	0.00e+00	1089.00
IUUC-Uma-129609	Ustilago maydis	33.73	9.00e-21	95.90
IUUC-Vda-130004	Verticillium dahliae	29.79	2.00e-40	160.00
IUUC-Vpa-130029	Vicugna pacos	89.47	1.00e-162	566.00
IUUC-Vvi-131117	Vitis vinifera	41.77	1.00e-82	301.00
IUUC-Xma-133279	Xiphophorus maculatus	50.62	0.00e+00	652.00
IUUC-Yli-134477	Yarrowia lipolytica	28.39	7.00e-25	108.00
IUUC-Zma-135837	Zea mays	42.31	5.00e-95	342.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence