iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	miRWalk	TargetScan
miRecords	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
InWeb_IM
Disease-associated Information
GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	SOCS	15695332

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.20e-15	58.8	473	520

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
            + l r+ p+SLq++CR +I+rc++++++   d+LPLP++L+d+L++++y+
   Q: 473  TISLNRTFPFSLQYICRAVICRCTTYDGI---DGLPLPSMLQDFLKEYHYK 520
           6778999**********************...****************985 PP

Organism

Homo sapiens

Functional Description
(View)

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.

Protein Sequence
(Fasta)

MDKVGKMWNN FKYRCQNLFG HEGGSRSENV DMNSNRCLSV KEKNISIGDS TPQQQSSPLR 60
ENIALQLGLS PSKNSSRRNQ NCATEIPQIV EISIEKDNDS CVTPGTRLAR RDSYSRHAPW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCAGCCGCG CAGAGCGCGC ACCCAAGCGG CCGGACCTCC CCGACTCCCG GGCCGCCCCC 60
GTCTCGCGCC CTGCCTCCCT CCTTCGGCCT TCACCTACCC GCCTCCGGAT TGGCCGCTAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0341--Growth regulation
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0734--Signal transduction inhibitor
KW-0833--Ubl conjugation pathway

Interpro

IPR000980--SH2
IPR022252--SOCS4/SOCS5_dom
IPR028420--SOCS5
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF12610--SOCS
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0004860--F:protein kinase inhibitor activity
GO:0030971--F:receptor tyrosine kinase binding
GO:0016049--P:cell growth
GO:0071404--P:cellular response to low-density lipoprotein particle stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0007259--P:JAK-STAT cascade
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0050728--P:negative regulation of inflammatory response
GO:0032715--P:negative regulation of interleukin-6 production
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0071638--P:negative regulation of monocyte chemotactic protein-1 production
GO:0009968--P:negative regulation of signal transduction
GO:0045629--P:negative regulation of T-helper 2 cell differentiation
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045627--P:positive regulation of T-helper 1 cell differentiation
GO:0016567--P:protein ubiquitination
GO:0040008--P:regulation of growth
GO:0097699--P:vascular endothelial cell response to fluid shear stress

KEGG

hsa:9655

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000371	Aegilops tauschii	36.73	1.50e-02	32.70
IUUC-Apl-003815	Anas platyrhynchos	91.60	0.00e+00	1012.00
IUUC-Aca-004504	Anolis carolinensis	85.07	0.00e+00	878.00
IUUC-Ame-010677	Astyanax mexicanus	63.46	0.00e+00	645.00
IUUC-Bta-012338	Bos taurus	97.95	0.00e+00	1052.00
IUUC-Cja-019828	Callithrix jacchus	98.13	0.00e+00	1029.00
IUUC-Cfa-020369	Canis familiaris	97.57	0.00e+00	1052.00
IUUC-Cpo-021397	Cavia porcellus	95.71	0.00e+00	1057.00
IUUC-Csa-023856	Chlorocebus sabaeus	99.63	0.00e+00	1063.00
IUUC-Dre-028262	Danio rerio	63.56	1.00e-173	603.00
IUUC-Dno-029019	Dasypus novemcinctus	97.95	0.00e+00	1077.00
IUUC-Dme-031965	Drosophila melanogaster	68.02	1.00e-69	258.00
IUUC-Eca-033867	Equus caballus	96.08	0.00e+00	1057.00
IUUC-Fca-035806	Felis catus	97.39	0.00e+00	1046.00
IUUC-Fal-037117	Ficedula albicollis	91.60	0.00e+00	1003.00
IUUC-Fso-038185	Fusarium solani	34.38	5.00e-02	31.60
IUUC-Gmo-039066	Gadus morhua	84.43	1.00e-108	386.00
IUUC-Gga-040876	Gallus gallus	91.04	0.00e+00	987.00
IUUC-Gac-042149	Gasterosteus aculeatus	67.41	0.00e+00	649.00
IUUC-Ggo-045169	Gorilla gorilla	98.88	0.00e+00	1058.00
IUUC-Hvu-047122	Hordeum vulgare	39.02	1.30e-02	33.50
IUUC-Itr-049048	Ictidomys tridecemlineatus	97.20	0.00e+00	1066.00
IUUC-Lch-049686	Latimeria chalumnae	79.41	0.00e+00	845.00
IUUC-Lpe-051639	Leersia perrieri	32.31	3.90e-02	33.50
IUUC-Loc-051745	Lepisosteus oculatus	72.61	0.00e+00	718.00
IUUC-Lma-053042	Leptosphaeria maculans	26.67	4.00e-01	32.70
IUUC-Laf-054124	Loxodonta africana	94.97	0.00e+00	1036.00
IUUC-Mcc-055175	Macaca mulatta	99.63	0.00e+00	1063.00
IUUC-Meu-056557	Macropus eugenii	92.39	0.00e+00	1025.00
IUUC-Mga-059214	Meleagris gallopavo	90.86	0.00e+00	1003.00
IUUC-Mmr-060613	Microcebus murinus	81.90	0.00e+00	815.00
IUUC-Mdo-062788	Monodelphis domestica	91.84	0.00e+00	983.00
IUUC-Mmu-064333	Mus musculus	94.40	0.00e+00	1017.00
IUUC-Mpu-066048	Mustela putorius furo	97.95	0.00e+00	1049.00
IUUC-Mlu-067430	Myotis lucifugus	97.39	0.00e+00	1019.00
IUUC-Nle-069086	Nomascus leucogenys	99.63	0.00e+00	1088.00
IUUC-Opr-070312	Ochotona princeps	92.72	0.00e+00	996.00
IUUC-Ont-072299	Oreochromis niloticus	64.36	0.00e+00	642.00
IUUC-Ocu-074123	Oryctolagus cuniculus	90.49	0.00e+00	972.00
IUUC-Ola-086934	Oryzias latipes	67.10	0.00e+00	662.00
IUUC-Oga-088535	Otolemur garnettii	97.57	0.00e+00	1072.00
IUUC-Oar-089875	Ovis aries	97.39	0.00e+00	1047.00
IUUC-Ptr-090541	Pan troglodytes	100.00	0.00e+00	1065.00
IUUC-Pan-092416	Papio anubis	99.63	0.00e+00	1063.00
IUUC-Psi-092960	Pelodiscus sinensis	89.74	0.00e+00	994.00
IUUC-Pma-094222	Petromyzon marinus	51.44	6.00e-137	481.00
IUUC-Pfo-096930	Poecilia formosa	64.83	0.00e+00	657.00
IUUC-Pab-098659	Pongo abelii	99.63	0.00e+00	1064.00
IUUC-Pca-100222	Procavia capensis	92.74	0.00e+00	1024.00
IUUC-Pva-102387	Pteropus vampyrus	97.39	0.00e+00	1041.00
IUUC-Rno-105698	Rattus norvegicus	95.15	0.00e+00	1028.00
IUUC-Sha-107234	Sarcophilus harrisii	91.09	0.00e+00	988.00
IUUC-Sar-113698	Sorex araneus	88.81	0.00e+00	910.00
IUUC-Ssc-115985	Sus scrofa	97.01	0.00e+00	1063.00
IUUC-Tgu-116676	Taeniopygia guttata	91.98	0.00e+00	1009.00
IUUC-Tru-118441	Takifugu rubripes	58.38	2.00e-150	526.00
IUUC-Tsy-119163	Tarsius syrichta	89.93	0.00e+00	989.00
IUUC-Tni-120436	Tetraodon nigroviridis	66.54	0.00e+00	647.00
IUUC-Tca-121188	Theobroma cacao	34.69	1.50e-01	30.80
IUUC-Tae-124846	Triticum aestivum	36.73	3.10e-02	31.60
IUUC-Tbe-127353	Tupaia belangeri	97.20	0.00e+00	1044.00
IUUC-Ttr-128907	Tursiops truncatus	97.76	0.00e+00	1027.00
IUUC-Vpa-130140	Vicugna pacos	97.39	0.00e+00	1049.00
IUUC-Xtr-132817	Xenopus tropicalis	80.63	0.00e+00	880.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence