iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	6.10e-20	73.0	46	114
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	5.40e-08	32.1	146	177

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd.vqpevfrallkFlYtgkldene 69
           +Dv+l+ g++ f++h++vLaa+S++F+a+f+++l+es+  ++v+++  + pev++ ll++ Y++++ +ne
   Q: 46   TDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQ-DSEVNFDNsIHPEVLELLLDYAYSSRVIINE 114
           7************************************9.*******77******************9987 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           + Nclg+l ++d+++c++L++   +++l++F+
   Q: 146  PTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQ 177
           78*****************************6 PP

Organism

Homo sapiens

Functional Description
(View)

Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism.

Protein Sequence
(Fasta)

MSVSVHENRK SRASSGSINI YLFHKSSYAD SVLTHLNLLR QQRLFTDVLL HAGNRTFPCH 60
RAVLAACSRY FEAMFSGGLK ESQDSEVNFD NSIHPEVLEL LLDYAYSSRV IINEENAESL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAGTCCAGC CGGGGGTGCC GCACCCACTG GGGAGTGGGG AGGGAGGACA CATAGGAAAT 60
GCCTGGGGCT GGAGTCTCTT TGGCTCTCTG CCAGCAAGAA ACTTAAACGT CCTGGCTTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0880--Kelch repeat
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR030562--ENC1
IPR015916--Gal_Oxidase_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0043025--C:neuronal cell body
GO:0000790--C:nuclear chromatin
GO:0016363--C:nuclear matrix
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0007275--P:multicellular organism development
GO:0017148--P:negative regulation of translation
GO:0007399--P:nervous system development
GO:0010976--P:positive regulation of neuron projection development
GO:0010499--P:proteasomal ubiquitin-independent protein catabolic process
GO:0016567--P:protein ubiquitination

KEGG

hsa:8507

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001434	Ailuropoda melanoleuca	99.83	0.00e+00	1192.00
IUUC-Apl-004096	Anas platyrhynchos	97.11	0.00e+00	1166.00
IUUC-Aca-004884	Anolis carolinensis	96.43	0.00e+00	1154.00
IUUC-Ame-011321	Astyanax mexicanus	88.62	0.00e+00	1112.00
IUUC-Bta-013178	Bos taurus	99.66	0.00e+00	1191.00
IUUC-Cja-019494	Callithrix jacchus	99.83	0.00e+00	1192.00
IUUC-Cfa-020824	Canis familiaris	99.83	0.00e+00	1192.00
IUUC-Cpo-021874	Cavia porcellus	99.49	0.00e+00	1189.00
IUUC-Csa-023075	Chlorocebus sabaeus	99.83	0.00e+00	1192.00
IUUC-Cho-024542	Choloepus hoffmanni	99.15	0.00e+00	1186.00
IUUC-Dre-028448	Danio rerio	88.79	0.00e+00	1117.00
IUUC-Dno-029952	Dasypus novemcinctus	99.49	0.00e+00	1189.00
IUUC-Dor-030844	Dipodomys ordii	99.83	0.00e+00	1192.00
IUUC-Ete-032817	Echinops telfairi	91.68	0.00e+00	1088.00
IUUC-Eca-033651	Equus caballus	99.83	0.00e+00	1192.00
IUUC-Fca-036541	Felis catus	99.83	0.00e+00	1192.00
IUUC-Fal-036968	Ficedula albicollis	97.11	0.00e+00	1165.00
IUUC-Gmo-038821	Gadus morhua	88.12	0.00e+00	1103.00
IUUC-Gga-040468	Gallus gallus	97.11	0.00e+00	1166.00
IUUC-Gac-041686	Gasterosteus aculeatus	89.30	0.00e+00	1114.00
IUUC-Ggo-044621	Gorilla gorilla	99.83	0.00e+00	1192.00
IUUC-Itr-048320	Ictidomys tridecemlineatus	99.66	0.00e+00	1191.00
IUUC-Lch-049735	Latimeria chalumnae	92.53	0.00e+00	1106.00
IUUC-Loc-052350	Lepisosteus oculatus	92.19	0.00e+00	1145.00
IUUC-Laf-054117	Loxodonta africana	99.15	0.00e+00	1187.00
IUUC-Mcc-054626	Macaca mulatta	99.83	0.00e+00	1192.00
IUUC-Meu-056763	Macropus eugenii	98.47	0.00e+00	1177.00
IUUC-Mmr-060579	Microcebus murinus	99.83	0.00e+00	1192.00
IUUC-Mdo-061995	Monodelphis domestica	98.47	0.00e+00	1177.00
IUUC-Mmu-064206	Mus musculus	99.32	0.00e+00	1187.00
IUUC-Mpu-066884	Mustela putorius furo	99.83	0.00e+00	1192.00
IUUC-Mlu-067183	Myotis lucifugus	99.83	0.00e+00	1192.00
IUUC-Nle-069928	Nomascus leucogenys	99.83	0.00e+00	1192.00
IUUC-Opr-070238	Ochotona princeps	99.49	0.00e+00	1186.00
IUUC-Ont-072404	Oreochromis niloticus	89.64	0.00e+00	1120.00
IUUC-Oan-073303	Ornithorhynchus anatinus	97.79	0.00e+00	1170.00
IUUC-Ocu-074119	Oryctolagus cuniculus	99.49	0.00e+00	1189.00
IUUC-Ola-087510	Oryzias latipes	89.56	0.00e+00	1070.00
IUUC-Oga-089119	Otolemur garnettii	99.83	0.00e+00	1192.00
IUUC-Oar-090036	Ovis aries	93.04	0.00e+00	1063.00
IUUC-Ptr-091349	Pan troglodytes	99.83	0.00e+00	1192.00
IUUC-Pan-092098	Papio anubis	99.83	0.00e+00	1192.00
IUUC-Pma-094515	Petromyzon marinus	60.00	0.00e+00	673.00
IUUC-Pfo-097496	Poecilia formosa	90.15	0.00e+00	1125.00
IUUC-Pab-098388	Pongo abelii	99.83	0.00e+00	1192.00
IUUC-Pca-100511	Procavia capensis	91.00	0.00e+00	1065.00
IUUC-Pva-102964	Pteropus vampyrus	99.83	0.00e+00	1192.00
IUUC-Rno-106059	Rattus norvegicus	99.49	0.00e+00	1188.00
IUUC-Sha-106470	Sarcophilus harrisii	98.47	0.00e+00	1177.00
IUUC-Sar-113403	Sorex araneus	98.98	0.00e+00	1222.00
IUUC-Ssc-115566	Sus scrofa	99.83	0.00e+00	1192.00
IUUC-Tgu-117331	Taeniopygia guttata	96.94	0.00e+00	1164.00
IUUC-Tru-117890	Takifugu rubripes	89.13	0.00e+00	1112.00
IUUC-Tni-120381	Tetraodon nigroviridis	74.57	0.00e+00	892.00
IUUC-Xtr-131810	Xenopus tropicalis	93.38	0.00e+00	1135.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence