iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	CircNet	miRTarBase	microRNA
TRANSFAC	TargetScan	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	19955572

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	0.0012	20.6	5	48

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 103  ldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
           ++ l  e+l  i+++ld ++++raa+vc  w+ +a +k++w+ v
   Q: 5    ISCLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGV 48
           56677899************************99999****976 PP

Organism

Homo sapiens

Functional Description
(View)

Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1.

Protein Sequence
(Fasta)

METHISCLFP ELLAMIFGYL DVRDKGRAAQ VCTAWRDAAY HKSVWRGVEA KLHLRRANPS 60
LFPSLQARGI RRVQILSLRR SLSYVIQGMA NIESLNLSGC YNLTDNGLGH AFVQEIGSLR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGGCGGCT GGGGAGAAGC GCTCTCGTCG CCTGCCCGAG GCCGGAGCGG CGGGGCCCGC 60
GCCTCCTCCC CCCAGCGCCG CGGAGGGGGG AGGAGGAAGA TGGAGACCCA CATCTCATGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0433--Leucine-rich repeat
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR006553--Leu-rich_rpt_Cys-con_subtyp

Pfam

PF12937--F-box-like
PF13516--LRR_6

SMART

SM00367--LRR_CC

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

hsa:144699

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002246	Ailuropoda melanoleuca	100.00	0.00e+00	793.00
IUUC-Apl-003553	Anas platyrhynchos	93.16	1.00e-149	522.00
IUUC-Aca-004590	Anolis carolinensis	94.15	4.00e-98	350.00
IUUC-Ame-011225	Astyanax mexicanus	91.96	0.00e+00	744.00
IUUC-Bta-012544	Bos taurus	100.00	0.00e+00	793.00
IUUC-Cja-019913	Callithrix jacchus	100.00	0.00e+00	793.00
IUUC-Cfa-020197	Canis familiaris	100.00	4.00e-175	607.00
IUUC-Cpo-022294	Cavia porcellus	94.47	0.00e+00	741.00
IUUC-Csa-023181	Chlorocebus sabaeus	100.00	0.00e+00	765.00
IUUC-Dre-028033	Danio rerio	92.71	0.00e+00	746.00
IUUC-Dno-029787	Dasypus novemcinctus	100.00	0.00e+00	793.00
IUUC-Dme-031589	Drosophila melanogaster	63.24	2.00e-141	495.00
IUUC-Ete-032977	Echinops telfairi	100.00	0.00e+00	793.00
IUUC-Eca-033691	Equus caballus	94.24	0.00e+00	727.00
IUUC-Fca-035767	Felis catus	100.00	0.00e+00	779.00
IUUC-Fal-037251	Ficedula albicollis	94.97	0.00e+00	724.00
IUUC-Gmo-039594	Gadus morhua	90.45	0.00e+00	732.00
IUUC-Ggr-039725	Gaeumannomyces graminis	28.24	1.00e-31	132.00
IUUC-Gga-040176	Gallus gallus	93.87	0.00e+00	730.00
IUUC-Gac-041451	Gasterosteus aculeatus	88.76	0.00e+00	749.00
IUUC-Ggo-044920	Gorilla gorilla	100.00	1.00e-172	598.00
IUUC-Itr-048932	Ictidomys tridecemlineatus	100.00	0.00e+00	678.00
IUUC-Kpa-049189	Komagataella pastoris	28.78	2.00e-21	98.60
IUUC-Lch-050647	Latimeria chalumnae	92.71	0.00e+00	746.00
IUUC-Loc-051978	Lepisosteus oculatus	92.46	0.00e+00	746.00
IUUC-Mcc-055878	Macaca mulatta	100.00	0.00e+00	836.00
IUUC-Meu-056536	Macropus eugenii	99.47	0.00e+00	743.00
IUUC-Mmr-061440	Microcebus murinus	95.94	0.00e+00	791.00
IUUC-Mdo-062821	Monodelphis domestica	99.75	0.00e+00	792.00
IUUC-Mmu-063826	Mus musculus	100.00	0.00e+00	793.00
IUUC-Mpu-066312	Mustela putorius furo	100.00	0.00e+00	793.00
IUUC-Mlu-067341	Myotis lucifugus	99.75	0.00e+00	791.00
IUUC-Nle-069771	Nomascus leucogenys	100.00	0.00e+00	836.00
IUUC-Ont-072668	Oreochromis niloticus	88.94	0.00e+00	743.00
IUUC-Ocu-073972	Oryctolagus cuniculus	96.17	0.00e+00	801.00
IUUC-Ola-087359	Oryzias latipes	91.77	0.00e+00	741.00
IUUC-Olu-087656	Ostreococcus lucimarinus	32.65	2.00e-06	46.60
IUUC-Oga-088437	Otolemur garnettii	100.00	0.00e+00	793.00
IUUC-Ptr-091419	Pan troglodytes	97.82	0.00e+00	791.00
IUUC-Pan-091932	Papio anubis	96.42	0.00e+00	805.00
IUUC-Psi-093623	Pelodiscus sinensis	95.67	3.00e-152	531.00
IUUC-Pma-094244	Petromyzon marinus	77.15	1.00e-149	522.00
IUUC-Pfo-097490	Poecilia formosa	91.96	0.00e+00	740.00
IUUC-Pab-098368	Pongo abelii	100.00	0.00e+00	836.00
IUUC-Pca-100216	Procavia capensis	100.00	2.00e-156	544.00
IUUC-Sha-107456	Sarcophilus harrisii	97.56	0.00e+00	626.00
IUUC-Tru-117892	Takifugu rubripes	90.19	0.00e+00	755.00
IUUC-Vpa-130165	Vicugna pacos	98.97	3.00e-163	566.00
IUUC-Xtr-132620	Xenopus tropicalis	94.97	0.00e+00	761.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence