iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000171931.12	ENST00000395665.8	ENSP00000379025.4
ENSG00000171931.12	ENST00000308799.8	ENSP00000310382.4
ENSG00000171931.12	ENST00000574478.1	ENSP00000463552.1
ENSG00000171931.12	ENST00000301938.4	ENSP00000306937.4

Annotation

Cancer Mutation
TCGA	ICGC	CGAP	IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
microRNA	TRANSFAC	TargetScan	RepTar
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	20498703

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.20e-27	94.2	493	530
UBD/Beta-Prp	6.70e-41	142.1	418	686

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvllks 38
           gH++ +tc+++ + ++lvsG++D+++kvWD++tg++lk+
   Q: 493  GHQGTITCMDL-CkNRLVSGGRDCQVKVWDVDTGKCLKT 530
           8**********.4489********************986 PP

UBD/Beta-Prp

   S: 16   vkfspdksllatgsrdgtikvwdvttgkll.rslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsg 106
           +++  +++l+a++s +++i + d+ + k++  ++ gh + v+a+ + +++++l++gs D  i+ wdl++g c++++ gh+ +++++++++  
   Q: 418  IHY-SGGDLIAVSS-NRKIHLLDIIQVKAIpVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCK-- 505
           455.6778888887.***********99962567********************************************************.. PP
   S: 107  dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsg 198
           ++lvsG++d  ++vwd++tg+cl+ t+  h++ +  +++++   ++vs++  + v++W +++++l++tl+g h+++v++l fd+   +l+sg
   Q: 506  NRLVSGGRDCQVKVWDVDTGKCLK-TF-RHKDPILATRIND--TYIVSSCERGLVKVWHIAMAQLVKTLSG-HEGAVKCLFFDQ--WHLLSG 590
           ***********************9.55.5777888889988..***************************9.************..8***** PP
   S: 199  sldgtvklwdlq..tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedsk 288
           s+dg v  w++    ++c+++++  ++   +  ++    r++s+ +Dg iri++  +g+++k+l+  n +  +v  + +++n +v  +e s+
   Q: 591  STDGLVMAWSMVgkYERCLMAFKHPKEVLDVSLLF---LRVISACADGKIRIYNFLNGNCMKVLKA-NGRGDPVLSFFIQGNRMVVNTE-SN 677
           ***********988899999998777666655555...89************************99.5555555555668888888877.68 PP
   S: 289  vniwklkkn 297
           v +++++ +
   Q: 678  VLMFQFEHI 686
           888887665 PP

Organism

Homo sapiens

Functional Description
(View)

Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1.

Protein Sequence
(Fasta)

MENLESRLKN APYFRCEKGT DSIPLCRKCE TCVLAWKIFS TKEWFCRIND ISQRRFLVGI 60
LKQLNSLYLL HYFQNILQTT QGKDFIYNRS RINLSKKEGK VVKSSLNQML DKTVEQKMKE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTTCCAA GGAGGTCTGT ACAAAAAGCC AGACTTCTGC TGGCAGTTAC TGAGAGAGAT 60
AGGCTTTCCA TCCATGGCAG CCATTTACTT TTGCTCTGGG AGACGTTTGT AATAGAAAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity
GO:0000209--P:protein polyubiquitination

KEGG

hsa:10517

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003572	Anas platyrhynchos	39.80	5.00e-163	568.00
IUUC-Aca-004297	Anolis carolinensis	44.68	2.00e-172	600.00
IUUC-Ame-011058	Astyanax mexicanus	38.98	4.00e-141	495.00
IUUC-Cja-019163	Callithrix jacchus	85.38	0.00e+00	1839.00
IUUC-Cfa-020784	Canis familiaris	77.13	0.00e+00	1650.00
IUUC-Csa-023597	Chlorocebus sabaeus	93.87	0.00e+00	1330.00
IUUC-Cho-024559	Choloepus hoffmanni	63.60	0.00e+00	657.00
IUUC-Dre-027496	Danio rerio	44.42	5.00e-112	398.00
IUUC-Dno-028995	Dasypus novemcinctus	75.88	0.00e+00	1578.00
IUUC-Eca-033666	Equus caballus	76.23	0.00e+00	1354.00
IUUC-Eeu-035054	Erinaceus europaeus	72.91	5.00e-97	349.00
IUUC-Fca-035589	Felis catus	71.43	0.00e+00	1493.00
IUUC-Fal-037403	Ficedula albicollis	37.32	3.00e-141	496.00
IUUC-Gmo-038669	Gadus morhua	33.08	1.00e-73	271.00
IUUC-Gga-041227	Gallus gallus	40.30	6.00e-160	558.00
IUUC-Itr-049011	Ictidomys tridecemlineatus	75.59	0.00e+00	1587.00
IUUC-Lch-050046	Latimeria chalumnae	36.61	0.00e+00	693.00
IUUC-Loc-052366	Lepisosteus oculatus	42.65	2.00e-160	560.00
IUUC-Laf-053745	Loxodonta africana	73.99	0.00e+00	1589.00
IUUC-Mcc-054826	Macaca mulatta	94.11	0.00e+00	1999.00
IUUC-Meu-056636	Macropus eugenii	46.79	1.00e-54	208.00
IUUC-Mga-060185	Meleagris gallopavo	39.88	3.00e-156	545.00
IUUC-Mdo-062382	Monodelphis domestica	53.25	0.00e+00	713.00
IUUC-Mmu-063623	Mus musculus	68.66	0.00e+00	1416.00
IUUC-Mpu-066872	Mustela putorius furo	69.86	0.00e+00	1278.00
IUUC-Nle-069247	Nomascus leucogenys	95.32	0.00e+00	1499.00
IUUC-Ont-071926	Oreochromis niloticus	42.22	2.00e-96	347.00
IUUC-Oan-073411	Ornithorhynchus anatinus	43.61	0.00e+00	811.00
IUUC-Ocu-073893	Oryctolagus cuniculus	73.53	0.00e+00	1309.00
IUUC-Oar-089680	Ovis aries	68.50	0.00e+00	1472.00
IUUC-Ptr-091549	Pan troglodytes	94.11	0.00e+00	1997.00
IUUC-Pan-091904	Papio anubis	92.02	0.00e+00	1945.00
IUUC-Psi-093181	Pelodiscus sinensis	41.83	0.00e+00	813.00
IUUC-Pab-098067	Pongo abelii	96.10	0.00e+00	2075.00
IUUC-Pca-100867	Procavia capensis	71.08	0.00e+00	824.00
IUUC-Pva-102209	Pteropus vampyrus	77.54	0.00e+00	1122.00
IUUC-Rno-105374	Rattus norvegicus	63.25	0.00e+00	1287.00
IUUC-Sha-107459	Sarcophilus harrisii	48.47	9.00e-111	394.00
IUUC-Tgu-117261	Taeniopygia guttata	43.06	6.00e-102	364.00
IUUC-Tru-117705	Takifugu rubripes	45.91	1.00e-41	162.00
IUUC-Tbe-128015	Tupaia belangeri	67.64	0.00e+00	1068.00
IUUC-Ttr-128654	Tursiops truncatus	72.33	0.00e+00	1044.00
IUUC-Vpa-130176	Vicugna pacos	65.28	0.00e+00	909.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence