iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000090173.8	ENSMUST00000036085.10	ENSMUSP00000046156.4
ENSMUSG00000090173.8	ENSMUST00000177336.7	ENSMUSP00000135294.1
ENSMUSG00000090173.8	ENSMUST00000176577.1	ENSMUSP00000135870.1
ENSMUSG00000090173.8	ENSMUST00000150989.7	ENSMUSP00000117872.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.00e-26	91.5	508	545
UBD/Beta-Prp	1.90e-63	215.5	434	701

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sdtllvsGsdDgtikvWDlrtgvllks 38
           gH++ +tcl+    ++lvsG+ Dg++k WD+ tg++lk+
   Q: 508  GHQGTITCLDVyK-NRLVSGAKDGQVKEWDIETGKCLKT 545
           8*********643.79********************986 PP

UBD/Beta-Prp

   S: 17   kfspdksllatgsrdgtikvwdvttgkllrsl.sgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsp 104
           ++ ++++l+a +s +++i + d+ + k l     gh + v+a+ +s++++il++gs D  i+ wd++tg cv+++ gh+ ++++l++++
   Q: 434  HY-NGGDLMAISS-NRKIHLLDIMQTKELPIEfRGHAGSVRALFLSEEDNILLSGSYDLSIRYWDVKTGACVRIFYGHQGTITCLDVYK 520
           44.8899999998.9*******99988876555******************************************************** PP
   S: 105  sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngk 193
             ++lvsG +d  ++ wd+etg+cl+    +h++ +  +++++   ++vs++  ++v++W + t++l +tltg h+++v++l f++   
   Q: 521  --NRLVSGAKDGQVKEWDIETGKCLK--TFKHKDPILAAKISE--TYIVSSCERGIVKVWHVVTAQLQKTLTG-HEGAVKCLFFNE--W 600
           ..***********************9..67788899*******..***************************9.**********99..8 PP
   S: 194  elvsgsldgtvklwdlq..tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhn..ssvisvavlsfgdn 278
           +lvsg+ dg v  w++    ++c+++++ h + v++v ++    r++s+  Dg iri++  +g++lk+++  +  + v     + +++n
   Q: 601  HLVSGGADGLVMAWSMVgkYERCLMAFK-HPKEVLQVSLL--YLRVISACGDGKIRIYNFLNGNCLKVIKVDArgDPVL---SFFYQGN 683
           ****************988888999987.56677788888..799999999********************98433333...3334777 PP
   S: 279  vlvlgsedskvniwklkkn 297
            +v+   ds++ ++++++ 
   Q: 684  RMVAH-TDSNILVFQFENV 701
           77766.4688999988775 PP

Organism

Mus musculus

Functional Description
(View)

Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1 (By similarity).

Protein Sequence
(Fasta)

MENREPKLKQ APYFRCEKGP NWVPVCQKCE ACVLAWKIFA TKEWFRRVND ISQRRFLVSI 60
LGQLNSLYLL QYFQNILETT QGKDFIYNRS RIKLSRKGGK EEEVVKSSLN QMLDKTVERK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTCTAAGG AAGTCAGTAC AAAAAGCCAG ACTTCTACAG GCAGTTTCTG GGTCAGATCA 60
GTTTACCATC CATCGCAGTG CCTTACGGTT TCTCCAGATG TTCATCCCGA AGAGGCTCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001837	Ailuropoda melanoleuca	70.72	0.00e+00	656.00
IUUC-Apl-003572	Anas platyrhynchos	49.07	2.00e-125	443.00
IUUC-Aca-004297	Anolis carolinensis	43.79	2.00e-160	560.00
IUUC-Ame-011058	Astyanax mexicanus	38.17	1.00e-130	461.00
IUUC-Bta-012667	Bos taurus	69.76	0.00e+00	676.00
IUUC-Cja-019163	Callithrix jacchus	67.28	0.00e+00	1406.00
IUUC-Cfa-020784	Canis familiaris	69.19	0.00e+00	1467.00
IUUC-Cpo-021429	Cavia porcellus	68.63	0.00e+00	680.00
IUUC-Csa-023597	Chlorocebus sabaeus	73.03	0.00e+00	1039.00
IUUC-Cho-024559	Choloepus hoffmanni	59.73	9.00e-176	610.00
IUUC-Dre-027496	Danio rerio	43.86	8.00e-108	384.00
IUUC-Dno-028995	Dasypus novemcinctus	67.85	0.00e+00	1399.00
IUUC-Ete-032823	Echinops telfairi	76.76	7.00e-88	318.00
IUUC-Eca-033666	Equus caballus	66.52	0.00e+00	1160.00
IUUC-Eeu-035054	Erinaceus europaeus	67.89	9.00e-90	325.00
IUUC-Fca-035589	Felis catus	65.23	0.00e+00	1361.00
IUUC-Fal-037403	Ficedula albicollis	38.08	1.00e-138	487.00
IUUC-Gmo-038669	Gadus morhua	39.85	5.00e-53	202.00
IUUC-Gga-041227	Gallus gallus	47.81	6.00e-124	438.00
IUUC-Hsa-046221	Homo sapiens	68.66	0.00e+00	1466.00
IUUC-Itr-049011	Ictidomys tridecemlineatus	68.04	0.00e+00	1442.00
IUUC-Lch-050046	Latimeria chalumnae	35.08	3.00e-178	619.00
IUUC-Loc-052366	Lepisosteus oculatus	37.22	0.00e+00	633.00
IUUC-Laf-053745	Loxodonta africana	67.53	0.00e+00	1446.00
IUUC-Mcc-054826	Macaca mulatta	69.63	0.00e+00	1467.00
IUUC-Meu-056636	Macropus eugenii	45.31	1.00e-53	205.00
IUUC-Mga-060185	Meleagris gallopavo	44.68	8.00e-123	434.00
IUUC-Mdo-062382	Monodelphis domestica	51.20	0.00e+00	676.00
IUUC-Mpu-066872	Mustela putorius furo	62.17	0.00e+00	1134.00
IUUC-Mlu-067552	Myotis lucifugus	68.63	6.00e-180	624.00
IUUC-Nle-069247	Nomascus leucogenys	70.76	0.00e+00	1100.00
IUUC-Opr-070455	Ochotona princeps	69.21	0.00e+00	676.00
IUUC-Ont-071926	Oreochromis niloticus	42.36	2.00e-95	343.00
IUUC-Oan-073411	Ornithorhynchus anatinus	39.78	0.00e+00	733.00
IUUC-Ocu-073893	Oryctolagus cuniculus	68.31	0.00e+00	1196.00
IUUC-Oga-087937	Otolemur garnettii	69.85	0.00e+00	682.00
IUUC-Oar-089680	Ovis aries	66.63	0.00e+00	1399.00
IUUC-Ptr-091549	Pan troglodytes	65.29	0.00e+00	1356.00
IUUC-Pan-091904	Papio anubis	70.41	0.00e+00	1466.00
IUUC-Psi-093181	Pelodiscus sinensis	41.82	0.00e+00	795.00
IUUC-Pma-094711	Petromyzon marinus	42.63	4.00e-71	261.00
IUUC-Pab-098067	Pongo abelii	68.66	0.00e+00	1466.00
IUUC-Pca-100867	Procavia capensis	67.21	0.00e+00	756.00
IUUC-Pva-102209	Pteropus vampyrus	71.35	0.00e+00	1033.00
IUUC-Rno-105374	Rattus norvegicus	81.74	0.00e+00	1669.00
IUUC-Sha-107459	Sarcophilus harrisii	45.76	5.00e-105	374.00
IUUC-Tgu-117261	Taeniopygia guttata	43.85	3.00e-104	372.00
IUUC-Tru-117705	Takifugu rubripes	46.54	1.00e-42	165.00
IUUC-Tni-120365	Tetraodon nigroviridis	46.49	2.00e-41	162.00
IUUC-Tbe-128015	Tupaia belangeri	62.26	0.00e+00	941.00
IUUC-Ttr-128654	Tursiops truncatus	67.18	0.00e+00	971.00
IUUC-Vpa-130176	Vicugna pacos	61.66	0.00e+00	849.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence