iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
miRNAMap	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Variation
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	5.80e-19	69.9	72	135
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	7.30e-11	41.2	171	201

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkl 65
           +Dvil+v+ +ef++h++vLaa+S +F+a+f ++l+e+  ++++ ik+v++e + +ll++ Yt+k+
   Q: 72   TDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKY-EKRIIIKGVDAETMHTLLDYTYTSKA 135
           7***********************************97.***********************987 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           +eNc+gilr+Ad+++++ Lk++++++i+++F
   Q: 171  PENCVGILRLADTHSLDSLKKQVQSYIIQNF 201
           89***************************** PP

Organism

Homo sapiens

Functional Description
(View)

Involved in B-lymphocyte antigen receptor signaling and germinal center formation.

Protein Sequence
(Fasta)

MLMAGQRGAW TMGDVVEKSL EGPLAPSTDE PSQKTGDLVE ILNGEKVKFD DAGLSLILQN 60
GLETLRMENA LTDVILCVDI QEFSCHRVVL AAASNYFRAM FCNDLKEKYE KRIIIKGVDA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGCCTGCCT GACACTTGGG CGCTCCTTCA GTCTCGATGT TGATGGCAGG ACAAAGGGGC 60
GCCTGGACCA TGGGTGATGT GGTCGAGAAG AGTTTGGAAG GGCCCCTGGC ACCTTCTACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR029851--KLHL6
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0000976--F:transcription regulatory region sequence-specific DNA binding
GO:0050853--P:B cell receptor signaling pathway
GO:0002467--P:germinal center formation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006357--P:regulation of transcription from RNA polymerase II promoter

KEGG

hsa:89857

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001509	Ailuropoda melanoleuca	98.07	0.00e+00	1275.00
IUUC-Apl-003490	Anas platyrhynchos	85.41	0.00e+00	1110.00
IUUC-Aca-005136	Anolis carolinensis	82.16	0.00e+00	1065.00
IUUC-Ame-010886	Astyanax mexicanus	66.77	0.00e+00	828.00
IUUC-Bta-013473	Bos taurus	96.62	0.00e+00	1231.00
IUUC-Cja-018888	Callithrix jacchus	98.36	0.00e+00	1256.00
IUUC-Cpo-021761	Cavia porcellus	88.51	0.00e+00	1112.00
IUUC-Csa-023206	Chlorocebus sabaeus	99.84	0.00e+00	1293.00
IUUC-Cin-025367	Ciona intestinalis	40.79	2.00e-132	466.00
IUUC-Csv-026076	Ciona savignyi	41.21	7.00e-126	444.00
IUUC-Dre-027948	Danio rerio	73.22	0.00e+00	902.00
IUUC-Dno-030045	Dasypus novemcinctus	96.93	0.00e+00	1258.00
IUUC-Dor-030839	Dipodomys ordii	88.89	0.00e+00	1124.00
IUUC-Ete-033161	Echinops telfairi	93.15	1.00e-160	560.00
IUUC-Eca-033608	Equus caballus	96.78	0.00e+00	1233.00
IUUC-Eeu-034640	Erinaceus europaeus	94.92	0.00e+00	1211.00
IUUC-Fca-036065	Felis catus	96.94	0.00e+00	1263.00
IUUC-Fal-036949	Ficedula albicollis	85.83	0.00e+00	1092.00
IUUC-Gmo-039661	Gadus morhua	58.12	5.00e-175	607.00
IUUC-Gga-040740	Gallus gallus	84.26	0.00e+00	1097.00
IUUC-Gac-042413	Gasterosteus aculeatus	61.35	0.00e+00	782.00
IUUC-Ggo-045167	Gorilla gorilla	99.84	0.00e+00	1294.00
IUUC-Itr-047926	Ictidomys tridecemlineatus	97.26	0.00e+00	1263.00
IUUC-Lch-049709	Latimeria chalumnae	79.32	0.00e+00	1036.00
IUUC-Loc-052239	Lepisosteus oculatus	77.70	0.00e+00	973.00
IUUC-Laf-054511	Loxodonta africana	96.23	0.00e+00	1232.00
IUUC-Mcc-055109	Macaca mulatta	99.84	0.00e+00	1289.00
IUUC-Meu-056522	Macropus eugenii	74.79	6.00e-104	371.00
IUUC-Mga-060012	Meleagris gallopavo	82.39	0.00e+00	1068.00
IUUC-Mmr-061364	Microcebus murinus	97.26	0.00e+00	1264.00
IUUC-Mdo-063033	Monodelphis domestica	82.95	0.00e+00	1016.00
IUUC-Mmu-063880	Mus musculus	94.67	0.00e+00	1193.00
IUUC-Mlu-068233	Myotis lucifugus	96.46	0.00e+00	1230.00
IUUC-Opr-070638	Ochotona princeps	95.54	0.00e+00	890.00
IUUC-Ont-071960	Oreochromis niloticus	61.58	0.00e+00	785.00
IUUC-Oan-073406	Ornithorhynchus anatinus	83.77	0.00e+00	1075.00
IUUC-Ocu-074612	Oryctolagus cuniculus	96.45	0.00e+00	1248.00
IUUC-Ola-087181	Oryzias latipes	59.19	0.00e+00	761.00
IUUC-Oga-088955	Otolemur garnettii	96.78	0.00e+00	1256.00
IUUC-Oar-089682	Ovis aries	96.62	0.00e+00	1231.00
IUUC-Ptr-090969	Pan troglodytes	99.84	0.00e+00	1293.00
IUUC-Pan-092289	Papio anubis	99.84	0.00e+00	1293.00
IUUC-Psi-093279	Pelodiscus sinensis	85.20	0.00e+00	1115.00
IUUC-Pab-097957	Pongo abelii	100.00	0.00e+00	952.00
IUUC-Pca-100619	Procavia capensis	93.06	0.00e+00	1220.00
IUUC-Pva-102533	Pteropus vampyrus	96.59	0.00e+00	755.00
IUUC-Rno-106111	Rattus norvegicus	94.83	0.00e+00	1224.00
IUUC-Sha-106716	Sarcophilus harrisii	83.63	0.00e+00	1070.00
IUUC-Tgu-116839	Taeniopygia guttata	85.25	0.00e+00	1105.00
IUUC-Tru-117792	Takifugu rubripes	60.13	0.00e+00	759.00
IUUC-Tsy-119609	Tarsius syrichta	91.75	4.00e-164	571.00
IUUC-Tni-119682	Tetraodon nigroviridis	60.10	0.00e+00	763.00
IUUC-Tme-127039	Tuber melanosporum	31.37	3.00e-12	68.20
IUUC-Tbe-127961	Tupaia belangeri	91.31	0.00e+00	1121.00
IUUC-Ttr-128917	Tursiops truncatus	95.78	0.00e+00	1048.00
IUUC-Vpa-130721	Vicugna pacos	97.64	0.00e+00	866.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence