iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000172915.18	ENST00000379939.6	ENSP00000369271.1
ENSG00000172915.18	ENST00000379922.3	ENSP00000369254.3
ENSG00000172915.18	ENST00000400445.7	ENSP00000383295.3
ENSG00000172915.18	ENST00000310336.8	ENSP00000308534.5
ENSG00000172915.18	ENST00000629018.2	ENSP00000486239.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.10e-06	29.0	296	329

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf......sdtllvsGsdDgtikvW 28
           gH d vtcla        d+++vsGs+D t+ +W
   Q: 296  GHWDVVTCLARsesyigGDCYIVSGSRDATLLLW 329
           68899***97667779766*************** PP

Organism

Homo sapiens

Functional Description
(View)

Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity).

Protein Sequence
(Fasta)

MFVNSNGYNL GVREDEVVVN DVDLPPWAKK PEDFVRINRM ALESEFVSCQ LHQWIDLIFG 60
YKQRGPEAVR ALNVFHYLTY EGSVNLDSIT DPVLREIPEA YFIRDPHTFL LTKDFIKAME 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGCAGGGGG CGGCAACATG GCGGAGTGAG CGGCGGCGTC GGGGCTTCAC AACAACAGTG 60
GTGGCCGTAG CAGCGGCGGC AGCAGCGTCA ATAGCATCGG CCACAGCCTG AGCTTCAGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000409--BEACH_dom
IPR013320--ConA-like_dom
IPR010508--DUF1088
IPR031570--DUF4704
IPR023362--PH-BEACH_dom
IPR011993--PH_dom-like
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50197--BEACH
PS51783--PH_BEACH
PS50294--WD_REPEATS_REGION

Pfam

PF02138--Beach
PF06469--DUF1088
PF15787--DUF4704
PF14844--PH_BEACH

SMART

SM01026--Beach
SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0012505--C:endomembrane system
GO:0005886--C:plasma membrane
GO:0005802--C:trans-Golgi network
GO:0008104--P:protein localization

KEGG

hsa:26960

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003632	Anas platyrhynchos	69.74	0.00e+00	738.00
IUUC-Aca-005124	Anolis carolinensis	69.47	0.00e+00	775.00
IUUC-Ame-011487	Astyanax mexicanus	93.60	0.00e+00	805.00
IUUC-Bta-012509	Bos taurus	69.47	0.00e+00	779.00
IUUC-Cja-018820	Callithrix jacchus	99.81	0.00e+00	1064.00
IUUC-Cfa-020786	Canis familiaris	69.47	0.00e+00	775.00
IUUC-Cpo-021636	Cavia porcellus	68.19	0.00e+00	757.00
IUUC-Ete-032481	Echinops telfairi	60.88	0.00e+00	664.00
IUUC-Eca-033893	Equus caballus	70.42	0.00e+00	783.00
IUUC-Fca-035726	Felis catus	70.04	0.00e+00	764.00
IUUC-Fal-036871	Ficedula albicollis	68.87	0.00e+00	772.00
IUUC-Gga-041206	Gallus gallus	69.43	0.00e+00	786.00
IUUC-Itr-048852	Ictidomys tridecemlineatus	69.85	0.00e+00	775.00
IUUC-Lch-050342	Latimeria chalumnae	91.22	0.00e+00	1005.00
IUUC-Loc-052771	Lepisosteus oculatus	68.13	0.00e+00	768.00
IUUC-Laf-053724	Loxodonta africana	69.66	0.00e+00	777.00
IUUC-Mcc-055200	Macaca mulatta	70.23	0.00e+00	769.00
IUUC-Mga-059851	Meleagris gallopavo	68.49	0.00e+00	768.00
IUUC-Mmr-061252	Microcebus murinus	99.81	0.00e+00	1065.00
IUUC-Mdo-062727	Monodelphis domestica	70.42	0.00e+00	790.00
IUUC-Mmu-064194	Mus musculus	69.47	0.00e+00	757.00
IUUC-Mpu-066074	Mustela putorius furo	70.42	0.00e+00	780.00
IUUC-Mlu-067308	Myotis lucifugus	69.89	0.00e+00	790.00
IUUC-Oan-073413	Ornithorhynchus anatinus	70.29	0.00e+00	769.00
IUUC-Ocu-074483	Oryctolagus cuniculus	71.56	0.00e+00	809.00
IUUC-Ola-087242	Oryzias latipes	68.62	0.00e+00	765.00
IUUC-Oga-088409	Otolemur garnettii	70.04	0.00e+00	775.00
IUUC-Oar-089217	Ovis aries	69.66	0.00e+00	777.00
IUUC-Pca-100240	Procavia capensis	69.29	3.00e-175	610.00
IUUC-Rno-104971	Rattus norvegicus	69.08	0.00e+00	753.00
IUUC-Sha-107387	Sarcophilus harrisii	70.61	0.00e+00	785.00
IUUC-Tgu-117304	Taeniopygia guttata	69.06	0.00e+00	778.00
IUUC-Tru-118226	Takifugu rubripes	85.39	0.00e+00	918.00
IUUC-Tni-120595	Tetraodon nigroviridis	81.43	0.00e+00	775.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence