iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000173064.11	ENST00000377560.9	ENSP00000366783.7
ENSG00000173064.11	ENST00000548588.2	ENSP00000477079.1
ENSG00000173064.11	ENST00000550724.2	ENSP00000448061.2
ENSG00000173064.11	ENST00000550722.5	ENSP00000449784.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
ArrayExpress	TCGA	ICGC	THPA
HPM
DNA & RNA Element
AREsite	circRNADb	CircNet	TRANSFAC
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
Mentha
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/HECT	HECT	20175895

Classification

Family	E-value	Score	Start	End
E3 activity/HECT	2.70e-80	271.9	3918	4278

Active Site

Position(s)	Description	Evidence
3964	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.......lysendketlqpnpdsglknpehlklFeflGrllgkalqdgr 86
           d ++ ++++f+gEe+++++G++r+fl++++kelq+++l+l+       ++++++k+ l+p+p ++     +++l +flG+llg+a++ + 
   Q: 3918 DPTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLllcpssaVNKNKGKYILTPSPITY----GEEQLLHFLGQLLGIAIRADV 4003
           5667788*********************************9999999888888***********9....789****************** PP
   S: 87   lldlplsksfyklllgkklsl.edleevdpelyks.lkeikenaesdieelgldltfs..vseei...............lgetkeeeLk 157
           +l+l+l +sf+k+l+g++l+  +dl+e d  +y++ +k+ + n+e+++e+l+++++++  +  ++                 + +e+eL+
   Q: 4004 PLPLDLLPSFWKTLVGEPLDPeQDLQEADILTYNYvKKFESINDETELEALCAEIASQhlA--TEspdspnkpccrftylTMTGEEVELC 4091
           *********************9*************56666677789999999999999532..33468999*******6555556667** PP
   S: 158  pgGenipVtneNkeeYvklvveyrlke.gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspai 246
           ++G++i V++eNk+ Y  ++ ++rl+e +  e+v+a+r+G+ ++ipl+ll+++++ e+el +cG ++i++e lk++t+y+ g++e++++i
   Q: 4092 SRGRHILVAWENKDIYAAAIRSLRLRElQNVECVTAVRAGLGSIIPLQLLTMLSPLEMELRTCGLPYINLEFLKAHTMYQVGLMETDQHI 4181
           ***************************9************************************************************** PP
   S: 247  qwFwevleefsseerkafLqFvTgssrlPl......gGfaelk....prlfvirk...dasddrlPssnTCfnyLkLPeYsskeilkekL 323
           ++Fw +le+f++ee ++f++F+++++r+P+      gG ++ +    p+++  ++    + d+r+++++TC++++kLP+Yss ei+ ekL
   Q: 4182 EFFWGALEMFTQEELCKFIKFACNQERIPFtcpckdGGPDTAHvppyPMKIAPPDgtaGSPDSRYIRVETCMFMIKLPQYSSLEIMLEKL 4271
           ************************************99999999988888888889955555**************************** PP
   S: 324  lyAieet 330
           ++Ai+++
   Q: 4272 RCAIHYR 4278
           ****986 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MGLLLVFPLI QSQSRTDPSL CNITAEVLLN CLRDCQPLSL TKEPADCLNG IETLLCSWLE 60
ETSDTGRHIP HKQKENAAAA LVALACARGS LKTFVHTVHL LQKQTDLGSL PVADVLYRLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCGGGAG CCCCGCCCCC AACATGGCGT CTCACTGACA GTTGGTTGCC GAGCGGCAGA 60
GGCGGATCCT GCTCCTGAGG GCGGCGGCGG CGGCGGCGGC GGCGGCGGCG GCAGGGCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0042593--P:glucose homeostasis
GO:0006006--P:glucose metabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002256	Ailuropoda melanoleuca	96.95	0.00e+00	7261.00
IUUC-Apl-004161	Anas platyrhynchos	92.53	0.00e+00	5179.00
IUUC-Aca-005341	Anolis carolinensis	88.67	0.00e+00	6638.00
IUUC-Ame-011574	Astyanax mexicanus	81.33	0.00e+00	4880.00
IUUC-Bta-012514	Bos taurus	97.50	0.00e+00	1946.00
IUUC-Cja-019148	Callithrix jacchus	98.48	0.00e+00	5356.00
IUUC-Cfa-020499	Canis familiaris	97.83	0.00e+00	7777.00
IUUC-Cpo-021894	Cavia porcellus	97.25	0.00e+00	2773.00
IUUC-Csa-023079	Chlorocebus sabaeus	99.32	0.00e+00	7914.00
IUUC-Cho-024415	Choloepus hoffmanni	92.84	0.00e+00	5092.00
IUUC-Dre-027452	Danio rerio	79.57	0.00e+00	4859.00
IUUC-Dno-029595	Dasypus novemcinctus	97.06	0.00e+00	7757.00
IUUC-Dor-030849	Dipodomys ordii	96.58	0.00e+00	1796.00
IUUC-Ete-032563	Echinops telfairi	90.33	0.00e+00	1610.00
IUUC-Eca-034202	Equus caballus	97.00	0.00e+00	7183.00
IUUC-Eeu-035175	Erinaceus europaeus	96.93	0.00e+00	1071.00
IUUC-Fca-036295	Felis catus	97.40	0.00e+00	7097.00
IUUC-Fal-037003	Ficedula albicollis	92.65	0.00e+00	6727.00
IUUC-Gmo-038579	Gadus morhua	84.51	0.00e+00	2878.00
IUUC-Gga-040961	Gallus gallus	92.77	0.00e+00	7491.00
IUUC-Gac-041899	Gasterosteus aculeatus	84.30	0.00e+00	2911.00
IUUC-Ggo-045099	Gorilla gorilla	99.83	0.00e+00	6544.00
IUUC-Itr-048190	Ictidomys tridecemlineatus	96.84	0.00e+00	2149.00
IUUC-Lch-049923	Latimeria chalumnae	84.23	0.00e+00	2659.00
IUUC-Loc-052630	Lepisosteus oculatus	84.09	0.00e+00	4044.00
IUUC-Laf-053394	Loxodonta africana	97.15	0.00e+00	7614.00
IUUC-Mcc-055763	Macaca mulatta	99.32	0.00e+00	7905.00
IUUC-Meu-056039	Macropus eugenii	89.10	0.00e+00	5095.00
IUUC-Mga-059500	Meleagris gallopavo	91.59	0.00e+00	6974.00
IUUC-Mmr-060868	Microcebus murinus	94.82	0.00e+00	7557.00
IUUC-Mdo-062772	Monodelphis domestica	94.33	0.00e+00	7629.00
IUUC-Mmu-063606	Mus musculus	96.83	0.00e+00	7774.00
IUUC-Mpu-065860	Mustela putorius furo	95.03	0.00e+00	7130.00
IUUC-Mlu-067376	Myotis lucifugus	96.37	0.00e+00	5376.00
IUUC-Nle-069693	Nomascus leucogenys	97.46	0.00e+00	7755.00
IUUC-Opr-071065	Ochotona princeps	94.87	0.00e+00	1220.00
IUUC-Ont-072470	Oreochromis niloticus	82.15	0.00e+00	4650.00
IUUC-Oan-073693	Ornithorhynchus anatinus	92.69	0.00e+00	5231.00
IUUC-Ocu-074032	Oryctolagus cuniculus	96.99	0.00e+00	7815.00
IUUC-Ola-087433	Oryzias latipes	83.28	0.00e+00	1598.00
IUUC-Oga-088546	Otolemur garnettii	98.30	0.00e+00	7016.00
IUUC-Oar-089643	Ovis aries	91.65	0.00e+00	761.00
IUUC-Ptr-090504	Pan troglodytes	98.83	0.00e+00	7442.00
IUUC-Pan-092543	Papio anubis	99.18	0.00e+00	7895.00
IUUC-Psi-093952	Pelodiscus sinensis	89.53	0.00e+00	6854.00
IUUC-Pfo-096356	Poecilia formosa	80.79	0.00e+00	6620.00
IUUC-Pab-098240	Pongo abelii	99.39	0.00e+00	7906.00
IUUC-Pca-100994	Procavia capensis	97.13	0.00e+00	3006.00
IUUC-Pva-102263	Pteropus vampyrus	95.51	0.00e+00	7130.00
IUUC-Rno-104888	Rattus norvegicus	96.71	0.00e+00	7506.00
IUUC-Sha-106944	Sarcophilus harrisii	92.78	0.00e+00	7119.00
IUUC-Sar-113556	Sorex araneus	83.38	0.00e+00	976.00
IUUC-Ssc-116187	Sus scrofa	98.01	0.00e+00	5187.00
IUUC-Tgu-116655	Taeniopygia guttata	92.32	0.00e+00	5127.00
IUUC-Tru-118093	Takifugu rubripes	83.39	0.00e+00	3013.00
IUUC-Tni-119739	Tetraodon nigroviridis	83.38	0.00e+00	1608.00
IUUC-Tbe-127962	Tupaia belangeri	93.26	0.00e+00	1224.00
IUUC-Ttr-128819	Tursiops truncatus	93.15	0.00e+00	2879.00
IUUC-Vpa-130482	Vicugna pacos	94.21	0.00e+00	4463.00
IUUC-Xtr-132222	Xenopus tropicalis	86.30	0.00e+00	6611.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence