iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000173327.7	ENST00000309100.7	ENSP00000309597.3
ENSG00000173327.7	ENST00000524848.5	ENSP00000431506.1
ENSG00000173327.7	ENST00000526293.1	ENSP00000435970.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Drug and target
TTD	GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
PHOSIDA	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.10e-14	54.9	47	102

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlvi...ekeeqdegWlkgvkelegkrGlfPenFvek 61
            +l+dye++ +deL l+kGd v+v+      + degW+ g  +  g+ G+fP+n+v +
   Q: 47   TALFDYEPSGQDELALRKGDRVEVLsrdAAISGDEGWWAG--QVGGQVGIFPSNYVSR 102
           69***********************66555689*******..7************975 PP

Organism

Homo sapiens

Functional Description
(View)

Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.

Protein Sequence
(Fasta)

MEPLKSLFLK SPLGSWNGSG SGGGGGGGGG RPEGSPKAAG YANPVWTALF DYEPSGQDEL 60
ALRKGDRVEV LSRDAAISGD EGWWAGQVGG QVGIFPSNYV SRGGGPPPCE VASFQELRLE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATTTCGCTC CCAGCGGCGT CTACTTCCGG GTCAGAGCTC AGACCTAGGG TGTAGAGAAC 60
AACCTTCCGT AACAGGCAGG AATAGTCGAA ATAGGATAGC GTCGTCTTTC TTAAAGTGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0723--Serine/threonine-protein kinase
KW-0728--SH3 domain
KW-0808--Transferase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR008271--Ser/Thr_kinase_AS
IPR001452--SH3_domain

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00220--S_TKc
SM00326--SH3

Gene Ontology

GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0005874--C:microtubule
GO:0005524--F:ATP binding
GO:0042802--F:identical protein binding
GO:0004706--F:JUN kinase kinase kinase activity
GO:0031435--F:mitogen-activated protein kinase kinase kinase binding
GO:0042803--F:protein homodimerization activity
GO:0004672--F:protein kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0007257--P:activation of JUN kinase activity
GO:0000187--P:activation of MAPK activity
GO:0008219--P:cell death
GO:0008283--P:cell proliferation
GO:0007254--P:JNK cascade
GO:0007017--P:microtubule-based process
GO:0043065--P:positive regulation of apoptotic process
GO:0046330--P:positive regulation of JNK cascade
GO:0043507--P:positive regulation of JUN kinase activity
GO:0043525--P:positive regulation of neuron apoptotic process
GO:0046777--P:protein autophosphorylation
GO:0006468--P:protein phosphorylation

KEGG

hsa:4296

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002080	Ailuropoda melanoleuca	93.45	0.00e+00	1038.00
IUUC-Ame-011785	Astyanax mexicanus	70.00	0.00e+00	709.00
IUUC-Bta-012372	Bos taurus	97.47	0.00e+00	1060.00
IUUC-Bol-015857	Brassica oleracea	32.84	6.00e-27	115.00
IUUC-Cja-019543	Callithrix jacchus	93.27	0.00e+00	1146.00
IUUC-Cfa-020080	Canis familiaris	97.39	0.00e+00	1003.00
IUUC-Cpo-022478	Cavia porcellus	92.58	0.00e+00	1161.00
IUUC-Csa-023280	Chlorocebus sabaeus	99.49	0.00e+00	1009.00
IUUC-Dno-030074	Dasypus novemcinctus	90.67	0.00e+00	1243.00
IUUC-Dor-030866	Dipodomys ordii	94.35	0.00e+00	1178.00
IUUC-Eca-033782	Equus caballus	96.96	3.00e-171	595.00
IUUC-Fca-035440	Felis catus	96.68	0.00e+00	1041.00
IUUC-Gac-042299	Gasterosteus aculeatus	61.99	0.00e+00	703.00
IUUC-Ggo-044795	Gorilla gorilla	99.41	0.00e+00	1261.00
IUUC-Itr-048561	Ictidomys tridecemlineatus	95.05	0.00e+00	1163.00
IUUC-Lch-049724	Latimeria chalumnae	63.17	0.00e+00	696.00
IUUC-Meu-056762	Macropus eugenii	90.58	0.00e+00	750.00
IUUC-Mdo-062929	Monodelphis domestica	83.03	0.00e+00	1153.00
IUUC-Mmu-063196	Mus musculus	94.12	0.00e+00	1181.00
IUUC-Mpu-066569	Mustela putorius furo	96.83	0.00e+00	1071.00
IUUC-Mlu-067815	Myotis lucifugus	92.66	0.00e+00	1138.00
IUUC-Ont-071274	Oreochromis niloticus	72.92	0.00e+00	713.00
IUUC-Ocu-074842	Oryctolagus cuniculus	93.03	0.00e+00	1191.00
IUUC-Olo-080520	Oryza longistaminata	31.79	1.00e-22	102.00
IUUC-Ome-081788	Oryza meridionalis	29.52	7.00e-31	129.00
IUUC-Oga-088038	Otolemur garnettii	95.40	0.00e+00	1204.00
IUUC-Oar-089467	Ovis aries	90.38	0.00e+00	1106.00
IUUC-Ptr-090955	Pan troglodytes	99.41	0.00e+00	1292.00
IUUC-Pan-091695	Papio anubis	98.47	0.00e+00	1274.00
IUUC-Psi-093760	Pelodiscus sinensis	75.41	0.00e+00	895.00
IUUC-Pfo-096248	Poecilia formosa	58.80	0.00e+00	700.00
IUUC-Pab-097966	Pongo abelii	99.41	0.00e+00	1293.00
IUUC-Pca-100802	Procavia capensis	98.35	3.00e-100	359.00
IUUC-Pva-102546	Pteropus vampyrus	93.76	0.00e+00	1153.00
IUUC-Rno-104963	Rattus norvegicus	93.54	0.00e+00	1251.00
IUUC-Sha-107470	Sarcophilus harrisii	78.86	0.00e+00	1078.00
IUUC-Tni-120577	Tetraodon nigroviridis	61.09	0.00e+00	707.00
IUUC-Ttr-129146	Tursiops truncatus	93.06	0.00e+00	1069.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence