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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046060
Ensembl Protein ID ENSP00000304350.6
UniProt Accession Q6P2Q9; O14547; O75965; PRP8_HUMAN
Genbank Protein ID AAC61776.1; BAA22563.1; AAH64370.1
Protein Name Pre-mRNA-processing-splicing factor 8; 220 kDa U5 snRNP-specific protein; PRP8 homolog; Splicing factor Prp8; p220
Genbank Nucleotide ID AF092565; AB007510; BC064370
Gene Name PRPF8; PRPC8
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000174231.16 ENST00000571958.1 ENSP00000459095.1
ENSG00000174231.16 ENST00000304992.10 ENSP00000304350.6
ENSG00000174231.16 ENST00000573725.1 ENSP00000460849.1
ENSG00000174231.16 ENST00000577001.1 ENSP00000458151.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircRNADbCircNetmiRTarBase
microRNATRANSFACmiRWalkTargetScan
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein 3D Structure
PDBMMDB
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Jab_MPN 62.26 0.00e+00 2945.00 IUUC-Sce-106157
UBD/Jab_MPN 62.21 0.00e+00 2945.00 IUUC-Ots-000011
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.
 Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.
Protein Sequence
(Fasta)
MAGVFPYRGP GNPVPGPLAP LPDYMSEEKL QEKARKWQQL QAKRYAEKRK FGFVDAQKED 60
MPPEHVRKII RDHGDMTNRK FRHDKRVYLG ALKYMPHAVL KLLENMPMPW EQIRDVPVLY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046060|UBD,Jab_MPN|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAACTCGGGT TGCGCACTTC CCGGCGCTGG GAACGCGGAG CGGACGCAGT CTGGCCGCCA 60
TTGCGCTGCG GGGAAAGCGG CCTCTTGTGT GAGGGCCTGT GGGGTGCGTG GCAGGCGTTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046060|UBD,Jab_MPN|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0488--Methylation
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0682--Retinitis pigmentosa
KW-0687--Ribonucleoprotein
KW-0694--RNA-binding
KW-0747--Spliceosome
Interpro

IPR000555--JAMM/MPN+_dom
IPR012591--PRO8NT
IPR012592--PROCN
IPR012984--PROCT
IPR027652--PRP8
IPR021983--PRP8_domainIV
IPR019581--Prp8_U5-snRNA-bd
IPR019580--Prp8_U6-snRNA-bd
IPR012337--RNaseH-like_dom
IPR019582--RRM_spliceosomal_PrP8
Pfam

PF01398--JAB
PF08082--PRO8NT
PF08083--PROCN
PF08084--PROCT
PF12134--PRP8_domainIV
PF10598--RRM_4
PF10597--U5_2-snRNA_bdg
PF10596--U6-snRNA_bdg
SMART

SM00232--JAB_MPN
Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0016020--C:membrane
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005682--C:U5 snRNP
GO:0070530--F:K63-linked polyubiquitin binding
GO:0003723--F:RNA binding
GO:0030623--F:U5 snRNA binding
GO:0017070--F:U6 snRNA binding
GO:0071222--P:cellular response to lipopolysaccharide
GO:0071356--P:cellular response to tumor necrosis factor
GO:0006397--P:mRNA processing
GO:0000398--P:mRNA splicing, via spliceosome
GO:0008380--P:RNA splicing
GO:0000375--P:RNA splicing, via transesterification reactions
GO:0000244--P:spliceosomal tri-snRNP complex assembly
KEGG hsa:10594
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001091 Aegilops tauschii 83.81 0.00e+00 3991.00
IUUC-Aml-002261 Ailuropoda melanoleuca 100.00 0.00e+00 4701.00
IUUC-Atr-002524 Amborella trichopoda 83.49 0.00e+00 4028.00
IUUC-Apl-004039 Anas platyrhynchos 99.56 0.00e+00 4496.00
IUUC-Aca-005394 Anolis carolinensis 97.81 0.00e+00 3705.00
IUUC-Aly-005909 Arabidopsis lyrata 82.70 0.00e+00 4003.00
IUUC-Ath-007237 Arabidopsis thaliana 83.57 0.00e+00 4028.00
IUUC-Ago-007815 Ashbya gossypii 62.20 0.00e+00 3036.00
IUUC-Acl-008111 Aspergillus clavatus 73.89 0.00e+00 3587.00
IUUC-Afl-008609 Aspergillus flavus 74.37 0.00e+00 2201.00
IUUC-Afu-009078 Aspergillus fumigatus 74.04 0.00e+00 2362.00
IUUC-Ani-009297 Aspergillus nidulans 72.98 0.00e+00 2322.00
IUUC-Ang-009749 Aspergillus niger 73.79 0.00e+00 3582.00
IUUC-Aor-010106 Aspergillus oryzae 73.84 0.00e+00 3585.00
IUUC-Ate-010566 Aspergillus terreus 73.98 0.00e+00 3588.00
IUUC-Ame-011416 Astyanax mexicanus 97.64 0.00e+00 4640.00
IUUC-Bgr-012078 Blumeria graminis 70.56 0.00e+00 2221.00
IUUC-Bta-013532 Bos taurus 100.00 0.00e+00 4701.00
IUUC-Bci-013914 Botrytis cinerea 73.57 0.00e+00 2338.00
IUUC-Bdi-014349 Brachypodium distachyon 83.61 0.00e+00 4030.00
IUUC-Bol-015707 Brassica oleracea 83.28 0.00e+00 4006.00
IUUC-Bra-017086 Brassica rapa 82.51 0.00e+00 3982.00
IUUC-Cel-018508 Caenorhabditis elegans 86.44 0.00e+00 4159.00
IUUC-Cja-019483 Callithrix jacchus 100.00 0.00e+00 4701.00
IUUC-Cfa-021018 Canis familiaris 100.00 0.00e+00 4701.00
IUUC-Cpo-022159 Cavia porcellus 100.00 0.00e+00 4701.00
IUUC-Cre-022998 Chlamydomonas reinhardtii 81.58 0.00e+00 3870.00
IUUC-Csa-023885 Chlorocebus sabaeus 100.00 0.00e+00 4701.00
IUUC-Cho-024639 Choloepus hoffmanni 94.42 0.00e+00 2585.00
IUUC-Cin-025356 Ciona intestinalis 84.06 0.00e+00 771.00
IUUC-Csv-025880 Ciona savignyi 91.28 0.00e+00 4333.00
IUUC-Cgl-026713 Colletotrichum gloeosporioides 70.97 0.00e+00 3430.00
IUUC-Cne-026874 Cryptococcus neoformans 75.37 0.00e+00 2240.00
IUUC-Cme-027252 Cyanidioschyzon merolae 33.78 0.00e+00 1010.00
IUUC-Dre-027996 Danio rerio 97.48 0.00e+00 4644.00
IUUC-Dno-029708 Dasypus novemcinctus 99.95 0.00e+00 4351.00
IUUC-Dor-030119 Dipodomys ordii 96.13 0.00e+00 4179.00
IUUC-Dse-031333 Dothistroma septosporum 73.03 0.00e+00 3493.00
IUUC-Dme-031908 Drosophila melanogaster 92.22 0.00e+00 4330.00
IUUC-Ete-032766 Echinops telfairi 94.52 0.00e+00 4435.00
IUUC-Eca-034109 Equus caballus 100.00 0.00e+00 4701.00
IUUC-Eeu-035094 Erinaceus europaeus 98.20 0.00e+00 2328.00
IUUC-Fca-035567 Felis catus 99.95 0.00e+00 3859.00
IUUC-Fal-036613 Ficedula albicollis 99.49 0.00e+00 4678.00
IUUC-Fox-037855 Fusarium oxysporum 72.30 0.00e+00 3506.00
IUUC-Fso-038078 Fusarium solani 72.00 0.00e+00 3490.00
IUUC-Gmo-038986 Gadus morhua 95.77 0.00e+00 4560.00
IUUC-Ggr-039855 Gaeumannomyces graminis 71.90 0.00e+00 3470.00
IUUC-Gga-040719 Gallus gallus 99.44 0.00e+00 4677.00
IUUC-Gac-042502 Gasterosteus aculeatus 97.46 0.00e+00 4613.00
IUUC-Gma-043317 Glycine max 83.45 0.00e+00 3999.00
IUUC-Ggo-045622 Gorilla gorilla 94.48 0.00e+00 4373.00
IUUC-Hvu-047251 Hordeum vulgare 84.54 0.00e+00 3751.00
IUUC-Itr-048517 Ictidomys tridecemlineatus 100.00 0.00e+00 2466.00
IUUC-Kpa-049289 Komagataella pastoris 65.02 0.00e+00 3141.00
IUUC-Lch-049690 Latimeria chalumnae 96.03 0.00e+00 4244.00
IUUC-Lpe-050868 Leersia perrieri 82.43 0.00e+00 3999.00
IUUC-Loc-052365 Lepisosteus oculatus 97.81 0.00e+00 4651.00
IUUC-Lma-053043 Leptosphaeria maculans 73.31 0.00e+00 3579.00
IUUC-Laf-053582 Loxodonta africana 100.00 0.00e+00 4701.00
IUUC-Mcc-055024 Macaca mulatta 100.00 0.00e+00 4701.00
IUUC-Meu-056637 Macropus eugenii 98.04 0.00e+00 4517.00
IUUC-Mor-057244 Magnaporthe oryzae 71.93 0.00e+00 3440.00
IUUC-Mpo-057580 Magnaporthe poae 71.94 0.00e+00 3478.00
IUUC-Mtr-058326 Medicago truncatula 83.49 0.00e+00 4031.00
IUUC-Mla-059121 Melampsora laricipopulina 76.43 0.00e+00 3613.00
IUUC-Mga-059789 Meleagris gallopavo 99.44 0.00e+00 4677.00
IUUC-Mvi-060563 Microbotryum violaceum 74.28 0.00e+00 3607.00
IUUC-Mmr-060880 Microcebus murinus 98.80 0.00e+00 4637.00
IUUC-Mdo-062237 Monodelphis domestica 99.83 0.00e+00 4697.00
IUUC-Mmu-064177 Mus musculus 99.91 0.00e+00 4700.00
IUUC-Mac-065558 Musa acuminata 81.87 0.00e+00 3826.00
IUUC-Mpu-066903 Mustela putorius furo 100.00 0.00e+00 4701.00
IUUC-Mlu-067424 Myotis lucifugus 99.79 0.00e+00 4690.00
IUUC-Nfi-068265 Neosartorya fischeri 73.92 0.00e+00 2359.00
IUUC-Ncr-068963 Neurospora crassa 72.63 0.00e+00 3506.00
IUUC-Nle-069111 Nomascus leucogenys 99.31 0.00e+00 3247.00
IUUC-Opr-070706 Ochotona princeps 98.46 0.00e+00 4585.00
IUUC-Ont-071405 Oreochromis niloticus 98.40 0.00e+00 4632.00
IUUC-Oan-073481 Ornithorhynchus anatinus 99.72 0.00e+00 2206.00
IUUC-Ocu-074231 Oryctolagus cuniculus 100.00 0.00e+00 4701.00
IUUC-Oba-075452 Oryza barthii 83.85 0.00e+00 3965.00
IUUC-Obr-076377 Oryza brachyantha 83.90 0.00e+00 3965.00
IUUC-Ogl-077666 Oryza glaberrima 83.74 0.00e+00 4018.00
IUUC-Ogu-078187 Oryza glumaepatula 83.90 0.00e+00 3967.00
IUUC-Oin-079234 Oryza indica 83.81 0.00e+00 3964.00
IUUC-Olo-080543 Oryza longistaminata 83.90 0.00e+00 3967.00
IUUC-Ome-081541 Oryza meridionalis 83.10 0.00e+00 3984.00
IUUC-Oni-082712 Oryza nivara 85.41 0.00e+00 3199.00
IUUC-Opu-083904 Oryza punctata 83.38 0.00e+00 4009.00
IUUC-Oru-084749 Oryza rufipogon 83.58 0.00e+00 4021.00
IUUC-Osa-085504 Oryza sativa 85.70 0.00e+00 2055.00
IUUC-Ola-087464 Oryzias latipes 98.14 0.00e+00 4356.00
IUUC-Olu-087705 Ostreococcus lucimarinus 81.03 0.00e+00 3935.00
IUUC-Oga-087910 Otolemur garnettii 100.00 8.00e-75 271.00
IUUC-Oar-089892 Ovis aries 99.87 0.00e+00 4696.00
IUUC-Ptr-090562 Pan troglodytes 96.80 0.00e+00 917.00
IUUC-Pan-092555 Papio anubis 100.00 0.00e+00 4577.00
IUUC-Psi-094049 Pelodiscus sinensis 99.49 0.00e+00 4677.00
IUUC-Pma-094240 Petromyzon marinus 93.85 0.00e+00 4275.00
IUUC-Pno-095146 Phaeosphaeria nodorum 71.44 0.00e+00 3468.00
IUUC-Ppa-095776 Physcomitrella patens 83.55 0.00e+00 4023.00
IUUC-Pfo-097177 Poecilia formosa 98.23 0.00e+00 4628.00
IUUC-Pab-097961 Pongo abelii 100.00 0.00e+00 4701.00
IUUC-Pop-099731 Populus trichocarpa 83.36 0.00e+00 4023.00
IUUC-Pca-100655 Procavia capensis 99.65 0.00e+00 1631.00
IUUC-Ppe-101199 Prunus persica 81.71 0.00e+00 3924.00
IUUC-Pva-103175 Pteropus vampyrus 99.55 0.00e+00 3616.00
IUUC-Pgr-103467 Puccinia graminis 76.17 0.00e+00 3620.00
IUUC-Ptt-103770 Puccinia triticina 69.77 0.00e+00 3245.00
IUUC-Pte-104210 Pyrenophora teres 72.70 0.00e+00 3530.00
IUUC-Pyt-104572 Pyrenophora triticirepentis 72.80 0.00e+00 2295.00
IUUC-Rno-105997 Rattus norvegicus 99.91 0.00e+00 4700.00
IUUC-Sce-106157 Saccharomyces cerevisiae 61.68 0.00e+00 2996.00
IUUC-Sha-107355 Sarcophilus harrisii 99.79 0.00e+00 4695.00
IUUC-Sja-107760 Schizosaccharomyces japonicus 74.29 0.00e+00 3554.00
IUUC-Spo-108160 Schizosaccharomyces pombe 73.94 0.00e+00 3557.00
IUUC-Ssl-108519 Sclerotinia sclerotiorum 73.43 0.00e+00 2329.00
IUUC-Smo-109278 Selaginella moellendorffii 83.59 0.00e+00 4011.00
IUUC-Sit-110777 Setaria italica 83.71 0.00e+00 4041.00
IUUC-Sly-110889 Solanum lycopersicum 83.60 0.00e+00 4035.00
IUUC-Stu-112016 Solanum tuberosum 83.51 0.00e+00 4035.00
IUUC-Sar-113245 Sorex araneus 95.57 0.00e+00 2679.00
IUUC-Sbi-114423 Sorghum bicolor 84.79 0.00e+00 1828.00
IUUC-Sre-115077 Sporisorium reilianum 67.24 0.00e+00 3259.00
IUUC-Ssc-116211 Sus scrofa 99.73 0.00e+00 4481.00
IUUC-Tgu-116697 Taeniopygia guttata 99.49 0.00e+00 4678.00
IUUC-Tru-117984 Takifugu rubripes 97.31 0.00e+00 4636.00
IUUC-Tsy-118893 Tarsius syrichta 99.87 0.00e+00 1550.00
IUUC-Tni-120620 Tetraodon nigroviridis 98.75 0.00e+00 3422.00
IUUC-Tca-121331 Theobroma cacao 83.67 0.00e+00 4014.00
IUUC-Tre-122031 Trichoderma reesei 72.90 0.00e+00 3503.00
IUUC-Tvi-122603 Trichoderma virens 72.47 0.00e+00 3487.00
IUUC-Tae-125167 Triticum aestivum 83.61 0.00e+00 4041.00
IUUC-Tur-126772 Triticum urartu 83.59 0.00e+00 3986.00
IUUC-Tme-126899 Tuber melanosporum 73.65 0.00e+00 3578.00
IUUC-Tbe-127364 Tupaia belangeri 99.93 0.00e+00 2973.00
IUUC-Ttr-129009 Tursiops truncatus 99.40 0.00e+00 4668.00
IUUC-Vda-130015 Verticillium dahliae 71.16 0.00e+00 2284.00
IUUC-Vpa-130769 Vicugna pacos 93.59 0.00e+00 1112.00
IUUC-Vvi-131030 Vitis vinifera 83.32 0.00e+00 3987.00
IUUC-Xtr-132067 Xenopus tropicalis 98.72 0.00e+00 4642.00
IUUC-Xma-134252 Xiphophorus maculatus 98.10 0.00e+00 4624.00
IUUC-Yli-134434 Yarrowia lipolytica 65.72 0.00e+00 3155.00
IUUC-Zma-134994 Zea mays 83.48 0.00e+00 4016.00
Created Date 25-Jun-2017

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