iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000174516.14	ENST00000349459.10	ENSP00000309848.8
ENSG00000174516.14	ENST00000320740.11	ENSP00000322532.7
ENSG00000174516.14	ENST00000524466.5	ENSP00000434677.1
ENSG00000174516.14	ENST00000618547.4	ENSP00000484220.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA
DNA & RNA Element
UTRdb	circRNADb	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	UniProt
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	16884718

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	4.8	9.4	415	449

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 14   vlpCgHvfhadClqkw...pglknssskefrCPlC 45
           + pCgHv  ++    w   p+++     ++ CP C
   Q: 415  FAPCGHVCSEKTARYWaqtPLPHGTHAFHAACPFC 449
           489***9444444555999888888999999***9 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation.

Protein Sequence
(Fasta)

MVLEGNPEVG SPRTSDLQHR GNKGSCVLSS PGEDAQPGEE PIKYGELIVL GCCEEGGEET 60
EAQRGEVTGP RAHSCYNGCL ASGDKGRRRS RLALSRRSHA NGVKPDVMHH ISTPLVSKAL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGACAGGTCT GCGACTCTGG TCAACTGCAG CTGCTTTCCC CGGCCTCCAC CGCTGCCGCA 60
CACCCCCTTT GCCTTTAGCA TTTTCCTCCT CTCCTCTAAT TGCGTGGCGT CCCCAGATGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR006800--Pellino_fam
IPR013083--Znf_RING/FYVE/PHD

Pfam

PF04710--Pellino

Gene Ontology

GO:0005829--C:cytosol
GO:0004674--F:protein serine/threonine kinase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0006955--P:immune response
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0010804--P:negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0070534--P:protein K63-linked ubiquitination
GO:0008063--P:Toll signaling pathway

KEGG

hsa:246330

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ani-009497	Aspergillus nidulans	45.71	1.30e-01	31.60
IUUC-Bta-012742	Bos taurus	98.29	0.00e+00	871.00
IUUC-Cja-019444	Callithrix jacchus	99.36	0.00e+00	857.00
IUUC-Cfa-021130	Canis familiaris	94.26	0.00e+00	841.00
IUUC-Dno-029295	Dasypus novemcinctus	98.51	0.00e+00	847.00
IUUC-Dor-031146	Dipodomys ordii	97.87	0.00e+00	862.00
IUUC-Eca-034003	Equus caballus	98.09	0.00e+00	863.00
IUUC-Ggo-045552	Gorilla gorilla	99.57	0.00e+00	859.00
IUUC-Mcc-055899	Macaca mulatta	99.57	0.00e+00	858.00
IUUC-Mmr-060623	Microcebus murinus	98.93	0.00e+00	878.00
IUUC-Nle-069909	Nomascus leucogenys	99.36	0.00e+00	855.00
IUUC-Opr-070627	Ochotona princeps	94.46	0.00e+00	807.00
IUUC-Oga-088275	Otolemur garnettii	97.25	0.00e+00	831.00
IUUC-Oar-090103	Ovis aries	95.31	0.00e+00	850.00
IUUC-Ptr-091182	Pan troglodytes	99.57	0.00e+00	859.00
IUUC-Pva-103049	Pteropus vampyrus	98.51	0.00e+00	874.00
IUUC-Sre-115102	Sporisorium reilianum	26.67	1.50e-01	32.30
IUUC-Ssc-115616	Sus scrofa	98.72	0.00e+00	852.00
IUUC-Tsy-119136	Tarsius syrichta	83.58	6.00e-178	616.00
IUUC-Tvi-122444	Trichoderma virens	38.10	2.60e+00	25.40

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence