iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-045331

UUCD1 version

UUC-GoG-00113

Ensembl Protein ID

ENSGGOP00000002690.2

UniProt Accession

G3QJT4; G3QJT4_GORGO

Protein Name

Uncharacterized protein

Gene Name

FBXW8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000002728.2	ENSGGOT00000002744.2	ENSGGOP00000002690.2
ENSGGOG00000002728.2	ENSGGOT00000031415.1	ENSGGOP00000024768.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.50e-14	52.2	382	415
UBD/Beta-Prp	8.00e-45	153.7	112	414

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrtgvl 35
           H+ +v++++ +d+ +vsG+  g + vWD+rt+ +
   Q: 382  HQLRVSAVQMDDWKIVSGGEEGLVSVWDYRTNQK 415
           7778999999669****************99865 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheae.........vtavkfspdgkilvtgseDrtikvwdlst 83
           +l++ +++v+++v+   ++ ++++g+++g ++vwd++t+++++ + + e+e         v+ v+++++  + v + eD+++++wdl+t
   Q: 112  ELEHVPDAVLCDVHS--HDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEedepgmqpnVSFVRINSS--LAVAAYEDGFLNIWDLRT 196
           67888999***8888..************************9999777777789999999*********..9***************** PP
   S: 84   gkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkl 171
           gk+ ++  +h++++ +l++s+++ +++++s+ +++++   e+g++  + + +  ++v+++++ p++ ++ v  ++ + ++ + lk ++ 
   Q: 197  GKYPVHRFEHDARIQALALSQDDATVATASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETrRYPVVVAAAGDLM-YLLKAEDS 284
           ***999999**********************************************************************8.******** PP
   S: 172  lrtltgghtdsvyslsfdsng.....kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs.pnderlvsgssDgsiriWdlrsg 254
            rtl  +h ++v++l+++ n+     + l ++ + +++ +++l++g+ + +l +  + +++v++s +  +++vsg++Dg +ri+dlrsg
   Q: 285  ARTLLYAHGPPVTCLDVSANQvafgvQGLGWVYEGSKILVYSLEAGRRLLKLGNVLRDFTCVNLSdSPPNLMVSGNMDGRVRIHDLRSG 373
           *****************************************************************78899******************* PP
   S: 255  dllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkkne 298
           ++  +l+ h+ +v++v++   +d+++v+g+e++ v +w++++n+
   Q: 374  NIALSLSAHQLRVSAVQM---DDWKIVSGGEEGLVSVWDYRTNQ 414
           ****************99...*******************9987 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MDDYSLDEFR RRWQNEMNDV PFFDIQLPYE LAINIFQYLD RKELGRCAQV SKTWKVIAED 60
EVLWYRLCQQ EGHLPDSSIS DYSCWKLIFQ ECRAKEHMLR SNWKNRKGAV SELEHVPDAV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACGACT ACAGCCTGGA TGAGTTCCGT CGGCGCTGGC AGGANNNNNN NNNNNNNNNN 60
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:1990393--C:3M complex
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008283--P:cell proliferation
GO:0007030--P:Golgi organization
GO:0060716--P:labyrinthine layer blood vessel development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0060712--P:spongiotrophoblast layer development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001274	Ailuropoda melanoleuca	87.09	0.00e+00	881.00
IUUC-Apl-003239	Anas platyrhynchos	61.41	0.00e+00	647.00
IUUC-Aca-004756	Anolis carolinensis	57.39	1.00e-127	449.00
IUUC-Ame-011198	Astyanax mexicanus	53.11	5.00e-53	201.00
IUUC-Bta-012430	Bos taurus	55.34	2.00e-144	506.00
IUUC-Cja-019131	Callithrix jacchus	92.48	0.00e+00	946.00
IUUC-Cfa-021022	Canis familiaris	87.70	0.00e+00	888.00
IUUC-Cpo-021898	Cavia porcellus	85.40	0.00e+00	882.00
IUUC-Csa-023452	Chlorocebus sabaeus	97.76	0.00e+00	998.00
IUUC-Cho-024759	Choloepus hoffmanni	73.78	0.00e+00	736.00
IUUC-Dre-028123	Danio rerio	48.00	1.00e-136	480.00
IUUC-Dno-029045	Dasypus novemcinctus	86.65	0.00e+00	820.00
IUUC-Dor-030433	Dipodomys ordii	83.13	0.00e+00	708.00
IUUC-Ete-032465	Echinops telfairi	83.54	0.00e+00	714.00
IUUC-Eca-034134	Equus caballus	86.59	0.00e+00	889.00
IUUC-Eeu-035047	Erinaceus europaeus	76.53	0.00e+00	763.00
IUUC-Fca-036574	Felis catus	86.91	0.00e+00	874.00
IUUC-Fal-037665	Ficedula albicollis	57.98	6.00e-165	573.00
IUUC-Gmo-039137	Gadus morhua	46.72	2.00e-62	232.00
IUUC-Gga-040711	Gallus gallus	61.41	0.00e+00	638.00
IUUC-Gac-041675	Gasterosteus aculeatus	48.94	2.00e-48	185.00
IUUC-Hsa-046240	Homo sapiens	98.98	0.00e+00	1015.00
IUUC-Itr-048412	Ictidomys tridecemlineatus	87.60	0.00e+00	872.00
IUUC-Loc-052631	Lepisosteus oculatus	52.13	9.00e-157	547.00
IUUC-Laf-054127	Loxodonta africana	71.33	3.00e-54	203.00
IUUC-Mcc-055083	Macaca mulatta	98.37	0.00e+00	1008.00
IUUC-Mga-060113	Meleagris gallopavo	60.79	0.00e+00	641.00
IUUC-Mmr-061780	Microcebus murinus	86.38	0.00e+00	875.00
IUUC-Mdo-063066	Monodelphis domestica	64.57	0.00e+00	672.00
IUUC-Mmu-063524	Mus musculus	81.10	0.00e+00	807.00
IUUC-Mpu-066913	Mustela putorius furo	87.09	0.00e+00	878.00
IUUC-Mlu-067924	Myotis lucifugus	86.15	0.00e+00	854.00
IUUC-Nle-069558	Nomascus leucogenys	97.64	0.00e+00	944.00
IUUC-Opr-070506	Ochotona princeps	85.45	0.00e+00	861.00
IUUC-Ont-071514	Oreochromis niloticus	46.59	3.00e-136	478.00
IUUC-Ocu-074477	Oryctolagus cuniculus	84.95	0.00e+00	856.00
IUUC-Ola-087416	Oryzias latipes	47.49	5.00e-135	474.00
IUUC-Oga-088643	Otolemur garnettii	87.60	0.00e+00	891.00
IUUC-Oar-090172	Ovis aries	85.19	0.00e+00	877.00
IUUC-Ptr-090870	Pan troglodytes	99.19	0.00e+00	1017.00
IUUC-Pan-092017	Papio anubis	97.56	0.00e+00	998.00
IUUC-Psi-093794	Pelodiscus sinensis	62.70	0.00e+00	645.00
IUUC-Pfo-096192	Poecilia formosa	49.40	9.00e-140	490.00
IUUC-Pab-097882	Pongo abelii	98.78	0.00e+00	1008.00
IUUC-Pca-100902	Procavia capensis	89.92	2.00e-129	456.00
IUUC-Pva-103139	Pteropus vampyrus	86.59	0.00e+00	887.00
IUUC-Rno-105798	Rattus norvegicus	79.88	0.00e+00	822.00
IUUC-Sha-106576	Sarcophilus harrisii	64.14	0.00e+00	657.00
IUUC-Ssc-115923	Sus scrofa	80.00	0.00e+00	816.00
IUUC-Tgu-116667	Taeniopygia guttata	52.27	7.00e-106	377.00
IUUC-Tru-118323	Takifugu rubripes	44.38	2.00e-127	449.00
IUUC-Tsy-118818	Tarsius syrichta	68.90	1.00e-94	340.00
IUUC-Tni-120438	Tetraodon nigroviridis	44.78	1.00e-123	437.00
IUUC-Tbe-127784	Tupaia belangeri	83.01	5.00e-96	344.00
IUUC-Ttr-128288	Tursiops truncatus	76.64	0.00e+00	763.00
IUUC-Vpa-130307	Vicugna pacos	83.33	0.00e+00	757.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence