iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000174989.12	ENST00000309909.9	ENSP00000310686.5
ENSG00000174989.12	ENST00000455858.2	ENSP00000389144.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	SomamiR	miRcode	RAID2
LncRNADisease
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	17998335; 14990695; 18539111; 18498745; 17205132; 17588513
UBD/Beta-Prp	Beta-Prp	21070969

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	5.70e-05	24.9	115	159
E3 adaptor/Cullin RING/DCX/DWD	2.90e-12	48.0	436	467
UBD/Beta-Prp	9.00e-45	154.8	204	507

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 102  lldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
              +lp+e+ ++i+++ld++el+r+a+v+++w+ +a+++ lw ++
   Q: 115  FDIQLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRL 159
           5679*****************************999999999765 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 7    tclaf..sd.tllvsGsdDgtikvWDlrtgvl 35
           tc+++  s  +l+vsG+ Dg +++ Dlr+g+ 
   Q: 436  TCVNLsdSPpNLMVSGNMDGRVRIHDLRSGNI 467
           89999873359*****************9975 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheae.........vtavkfspdgkilvtgseDrtikvwdlstgkc 86
           +l++ +++v+++v+   ++ ++++g+++g ++vwd++t+++++ + + e+e         v+ v+++++  + v + eD+++++wdl+tgk+
   Q: 204  ELEHVPDTVLCDVHS--HDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEedepgmqpnVSFVRINSS--LAVAAYEDGFLNIWDLRTGKY 291
           67888999***8888..************************9999777777789999999*********..9******************** PP
   S: 87   vhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltg 177
            ++  +h++++ +l++s+++ +++++s+ +++++   e+g++  + + +  ++v+++++ p++ ++ v+ ++ + ++ + lk ++  rtl  
   Q: 292  PVHRFEHDARIQALALSQDDATVATASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETrRYPVAVAAAGDLM-YLLKAEDSARTLLY 382
           999999**********************************************************************8.************** PP
   S: 178  ghtdsvyslsfdsng.....kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs.pnderlvsgssDgsiriWdlrsgdllktlqlh 263
           +h ++v++l+++ n+     + l ++ + +++ +++l++g+ + +l +  + +++v++s +  +++vsg++Dg +ri+dlrsg++  +l+ h
   Q: 383  AHGPPVTCLDVSANQvafgvQGLGWVYEGSKILVYSLEAGRRLLKLGNVLRDFTCVNLSdSPPNLMVSGNMDGRVRIHDLRSGNIALSLSAH 474
           ***********************************************************78899**************************** PP
   S: 264  nssvisvavlsfgdnvlvlgsedskvniwklkknep 299
           + +v++v++   +d+++v+g+e++ v +w++++n++
   Q: 475  QLRVSAVQM---DDWKIVSGGEEGLVSVWDYRMNQK 507
           *******99...********************9875 PP

Organism

Homo sapiens

Functional Description
(View)

Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695).

Protein Sequence
(Fasta)

MDDYSLDEFR RRWQEELAQA QAPKKRRRPE AAERRARRPE VGSGRGEQAS GDPALAQRLL 60
EGAGRPPAAR ATRAEGQDVA SRSRSPLARE GAGGGEQLVD QLIRDLNEMN DVPFFDIQLP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGCGGACA CTTCCCTGGG CGGGACTGTC TCGTGGCACC CGGTGGAACC GAGGAGAACG 60
TGGAGCGCCG GGAGCGGCGA ATATGGACGA CTACAGCCTG GATGAGTTCC GTCGGCGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0333--Golgi apparatus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008283--P:cell proliferation
GO:0007030--P:Golgi organization
GO:0060716--P:labyrinthine layer blood vessel development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0060712--P:spongiotrophoblast layer development

KEGG

hsa:26259

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001274	Ailuropoda melanoleuca	88.03	0.00e+00	945.00
IUUC-Apl-003239	Anas platyrhynchos	61.30	0.00e+00	674.00
IUUC-Aca-004756	Anolis carolinensis	57.88	3.00e-129	454.00
IUUC-Ame-011198	Astyanax mexicanus	54.30	1.00e-57	216.00
IUUC-Bta-012430	Bos taurus	61.25	4.00e-159	555.00
IUUC-Cja-019131	Callithrix jacchus	90.13	0.00e+00	1030.00
IUUC-Cfa-021022	Canis familiaris	78.70	0.00e+00	920.00
IUUC-Cpo-021898	Cavia porcellus	77.19	0.00e+00	902.00
IUUC-Csa-023452	Chlorocebus sabaeus	96.82	0.00e+00	1134.00
IUUC-Cho-024759	Choloepus hoffmanni	75.75	0.00e+00	835.00
IUUC-Dre-028123	Danio rerio	45.10	2.00e-141	496.00
IUUC-Dno-029045	Dasypus novemcinctus	87.31	0.00e+00	831.00
IUUC-Dor-030433	Dipodomys ordii	77.09	0.00e+00	769.00
IUUC-Ete-032465	Echinops telfairi	79.65	0.00e+00	744.00
IUUC-Eca-034134	Equus caballus	87.20	0.00e+00	898.00
IUUC-Eeu-035047	Erinaceus europaeus	76.94	0.00e+00	768.00
IUUC-Fca-036574	Felis catus	87.50	0.00e+00	882.00
IUUC-Fal-037665	Ficedula albicollis	59.28	4.00e-171	594.00
IUUC-Gmo-039137	Gadus morhua	46.83	2.00e-68	252.00
IUUC-Gga-040711	Gallus gallus	59.03	0.00e+00	663.00
IUUC-Gac-041675	Gasterosteus aculeatus	50.00	4.00e-50	190.00
IUUC-Ggo-045331	Gorilla gorilla	98.98	0.00e+00	1017.00
IUUC-Itr-048412	Ictidomys tridecemlineatus	88.21	0.00e+00	882.00
IUUC-Loc-052631	Lepisosteus oculatus	53.17	1.00e-163	570.00
IUUC-Laf-054127	Loxodonta africana	72.73	8.00e-56	209.00
IUUC-Mcc-055083	Macaca mulatta	97.66	0.00e+00	1119.00
IUUC-Mga-060113	Meleagris gallopavo	62.22	0.00e+00	646.00
IUUC-Mmr-061780	Microcebus murinus	86.48	0.00e+00	922.00
IUUC-Mdo-063066	Monodelphis domestica	61.35	0.00e+00	707.00
IUUC-Mmu-063524	Mus musculus	76.92	0.00e+00	842.00
IUUC-Mpu-066913	Mustela putorius furo	87.84	0.00e+00	919.00
IUUC-Mlu-067924	Myotis lucifugus	83.58	0.00e+00	932.00
IUUC-Nle-069558	Nomascus leucogenys	97.38	0.00e+00	1057.00
IUUC-Opr-070506	Ochotona princeps	83.16	0.00e+00	906.00
IUUC-Ont-071514	Oreochromis niloticus	47.94	7.00e-144	504.00
IUUC-Ocu-074477	Oryctolagus cuniculus	85.57	0.00e+00	865.00
IUUC-Ola-087416	Oryzias latipes	43.97	3.00e-144	505.00
IUUC-Oga-088643	Otolemur garnettii	86.62	0.00e+00	942.00
IUUC-Oar-090172	Ovis aries	86.48	0.00e+00	885.00
IUUC-Ptr-090870	Pan troglodytes	99.50	0.00e+00	1142.00
IUUC-Pan-092017	Papio anubis	96.49	0.00e+00	1134.00
IUUC-Psi-093794	Pelodiscus sinensis	63.23	0.00e+00	651.00
IUUC-Pfo-096192	Poecilia formosa	50.10	2.00e-146	512.00
IUUC-Pab-097882	Pongo abelii	97.99	0.00e+00	1118.00
IUUC-Pca-100902	Procavia capensis	83.14	6.00e-155	541.00
IUUC-Pva-103139	Pteropus vampyrus	85.48	0.00e+00	955.00
IUUC-Rno-105798	Rattus norvegicus	80.08	0.00e+00	849.00
IUUC-Sha-106576	Sarcophilus harrisii	64.96	0.00e+00	667.00
IUUC-Ssc-115923	Sus scrofa	76.88	0.00e+00	919.00
IUUC-Tgu-116667	Taeniopygia guttata	53.07	5.00e-108	384.00
IUUC-Tru-118323	Takifugu rubripes	43.09	1.00e-135	476.00
IUUC-Tsy-118818	Tarsius syrichta	70.08	5.00e-97	348.00
IUUC-Tni-120438	Tetraodon nigroviridis	42.49	2.00e-133	469.00
IUUC-Tbe-127784	Tupaia belangeri	83.98	1.00e-97	350.00
IUUC-Ttr-128288	Tursiops truncatus	78.32	0.00e+00	811.00
IUUC-Vpa-130307	Vicugna pacos	84.03	0.00e+00	801.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence