iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	miRTarBase	microRNA
TRANSFAC	TargetScan	RepTar	miRcode
RAID2
Protein-protein Interaction
IID
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	10831842
ULD/UDP/UBQ/UBQ_Other	UBQ_Other	10831842

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	1.10e-08	36.6	617	652
ULD/UDP/UBQ/UBQ_Other	2.20e-18	67.5	22	95

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGF.dreealqaLraannnleaAveyL 38
           + +leql++MGF +re++lqaL a++++++aAve L
   Q: 617  QVQLEQLRSMGFlNREANLQALIATGGDVDAAVEKL 652
           679******************************987 PP

ULD/UDP/UBQ/UBQ_Other

   S: 1    vqvtvksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllekksg 75
           ++vtvk+++++e +++v  ++t+++LKe+i+++++ +p+q  Li++GkiL+d+++La++g++dg t+hl+ k+ +
   Q: 22   IKVTVKTPKDKE-DFSVTDTCTIQQLKEEISQRFKAHPDQLVLIFAGKILKDPDSLAQCGVRDGLTVHLVIKRQH 95
           6899*****985.78899****************************************************99876 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MAKGGEALPQ GSPAPVQDPH LIKVTVKTPK DKEDFSVTDT CTIQQLKEEI SQRFKAHPDQ 60
LVLIFAGKIL KDPDSLAQCG VRDGLTVHLV IKRQHRAMGN ECPAASVPTQ GPSPGSLPQP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGGACCTGA TAGTGCGGGT TCTGGCCCAG AAGGCCTCAG GGGTGGCTGT GTAGCAAGAT 60
GAGGGAGGTT TGGAGCCCTG CATAAAGAGA AGGACGGGAC CACAGCTGAC TGGTATGTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome

Interpro

IPR006636--STI1_HS-bd
IPR015940--UBA
IPR009060--UBA-like
IPR015496--Ubiquilin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50030--UBA
PS50053--UBIQUITIN_2

Pfam

PF00627--UBA
PF00240--ubiquitin

SMART

SM00727--STI1
SM00165--UBA
SM00213--UBQ

KEGG

hsa:50613

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001302	Ailuropoda melanoleuca	77.56	0.00e+00	862.00
IUUC-Bgr-012188	Blumeria graminis	26.50	1.00e-10	61.20
IUUC-Bta-012941	Bos taurus	79.29	0.00e+00	739.00
IUUC-Cja-019387	Callithrix jacchus	88.11	0.00e+00	979.00
IUUC-Cfa-020572	Canis familiaris	79.24	0.00e+00	883.00
IUUC-Cpo-021846	Cavia porcellus	78.14	8.00e-121	427.00
IUUC-Csa-024187	Chlorocebus sabaeus	95.11	0.00e+00	1025.00
IUUC-Cho-024936	Choloepus hoffmanni	80.00	0.00e+00	899.00
IUUC-Dno-029226	Dasypus novemcinctus	79.69	0.00e+00	923.00
IUUC-Dse-031421	Dothistroma septosporum	29.18	2.00e-13	70.50
IUUC-Ete-032824	Echinops telfairi	69.51	0.00e+00	734.00
IUUC-Eca-033383	Equus caballus	75.22	0.00e+00	634.00
IUUC-Fca-035855	Felis catus	78.63	0.00e+00	843.00
IUUC-Ggo-045636	Gorilla gorilla	97.86	0.00e+00	1088.00
IUUC-Itr-049069	Ictidomys tridecemlineatus	81.98	0.00e+00	840.00
IUUC-Laf-054412	Loxodonta africana	84.81	2.00e-145	509.00
IUUC-Mcc-055310	Macaca mulatta	95.42	0.00e+00	1029.00
IUUC-Mmr-060687	Microcebus murinus	83.33	0.00e+00	874.00
IUUC-Mdo-062941	Monodelphis domestica	68.56	2.00e-122	432.00
IUUC-Mmu-063953	Mus musculus	73.40	0.00e+00	803.00
IUUC-Mpu-066645	Mustela putorius furo	87.25	5.00e-126	444.00
IUUC-Nle-069745	Nomascus leucogenys	96.18	0.00e+00	1019.00
IUUC-Ocu-073979	Oryctolagus cuniculus	79.27	0.00e+00	868.00
IUUC-Oga-088802	Otolemur garnettii	82.90	0.00e+00	898.00
IUUC-Oar-089721	Ovis aries	77.39	0.00e+00	785.00
IUUC-Ptr-091188	Pan troglodytes	87.94	0.00e+00	951.00
IUUC-Pma-094577	Petromyzon marinus	70.37	1.00e-28	117.00
IUUC-Pab-098116	Pongo abelii	97.40	0.00e+00	1079.00
IUUC-Pca-100194	Procavia capensis	71.45	6.00e-171	593.00
IUUC-Pva-102958	Pteropus vampyrus	80.25	0.00e+00	649.00
IUUC-Pte-104090	Pyrenophora teres	27.65	2.00e-08	53.90
IUUC-Pyt-104472	Pyrenophora triticirepentis	26.85	2.00e-09	57.00
IUUC-Rno-105161	Rattus norvegicus	74.96	0.00e+00	871.00
IUUC-Sha-107327	Sarcophilus harrisii	60.09	0.00e+00	647.00
IUUC-Sar-113022	Sorex araneus	74.39	0.00e+00	857.00
IUUC-Ssc-115333	Sus scrofa	74.05	2.00e-127	449.00
IUUC-Tsy-119637	Tarsius syrichta	76.23	0.00e+00	681.00
IUUC-Tbe-128150	Tupaia belangeri	76.14	4.00e-176	611.00
IUUC-Ttr-128507	Tursiops truncatus	75.42	0.00e+00	834.00
IUUC-Vpa-130797	Vicugna pacos	68.35	0.00e+00	754.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence