iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
microRNA	TRANSFAC	TargetScan	RepTar
miRNAMap	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/Cullin	Cullin_N_terminal	21107322; 16763193
E3 adaptor/Cullin RING/APC_C/APC_C	APC_C	21107322; 16763193

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
E3 adaptor/Cullin RING/APC_C/APC_C	22.71	7.00e-25	110.00	IUUC-Sce-106292

Organism

Homo sapiens

Functional Description
(View)

Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation.

Protein Sequence
(Fasta)

MAAAVVVAEG DSDSRPGQEL LVAWNTVSTG LVPPAALGLV SSRTSGAVPP KEEELRAAVE 60
VLRGHGLHSV LEEWFVEVLQ NDLQANISPE FWNAISQCEN SADEPQCLLL LLDAFGLLES 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGTCGGTG GGTGCAGATG GCGGCGGCAG TTGTGGTGGC GGAGGGGGAC AGCGACTCCC 60
GGCCCGGACA GGAGTTGTTA GTGGCCTGGA ACACCGTGAG CACCGGCCTG GTGCCGCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0221--Differentiation
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR014786--APC_su2_C
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50069--CULLIN_2

Pfam

PF08672--ANAPC2
PF00888--Cullin

SMART

SM01013--APC2
SM00182--CULLIN

Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0031625--F:ubiquitin protein ligase binding
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0045773--P:positive regulation of axon extension
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0090129--P:positive regulation of synapse maturation
GO:0031915--P:positive regulation of synaptic plasticity
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070979--P:protein K11-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051439--P:regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

KEGG

hsa:29882

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000110	Aegilops tauschii	35.22	3.00e-90	326.00
IUUC-Aml-001248	Ailuropoda melanoleuca	95.02	0.00e+00	1412.00
IUUC-Atr-002679	Amborella trichopoda	39.76	4.00e-97	349.00
IUUC-Apl-003362	Anas platyrhynchos	71.92	0.00e+00	1060.00
IUUC-Aca-004655	Anolis carolinensis	68.73	0.00e+00	1010.00
IUUC-Aly-006274	Arabidopsis lyrata	34.75	3.00e-95	343.00
IUUC-Ath-007394	Arabidopsis thaliana	37.13	1.00e-95	344.00
IUUC-Ago-007945	Ashbya gossypii	20.73	8.00e-14	72.40
IUUC-Acl-008276	Aspergillus clavatus	33.73	3.00e-71	263.00
IUUC-Afl-008425	Aspergillus flavus	31.80	8.00e-69	255.00
IUUC-Afu-008876	Aspergillus fumigatus	34.79	2.00e-70	260.00
IUUC-Ani-009501	Aspergillus nidulans	33.06	9.00e-73	268.00
IUUC-Ang-009519	Aspergillus niger	33.27	3.00e-66	246.00
IUUC-Aor-009911	Aspergillus oryzae	31.90	1.00e-68	254.00
IUUC-Ate-010350	Aspergillus terreus	37.32	6.00e-61	229.00
IUUC-Ame-011184	Astyanax mexicanus	55.86	0.00e+00	779.00
IUUC-Bgr-011977	Blumeria graminis	32.08	8.00e-69	255.00
IUUC-Bta-013406	Bos taurus	95.76	0.00e+00	1095.00
IUUC-Bci-013817	Botrytis cinerea	34.48	1.00e-66	248.00
IUUC-Bdi-014198	Brachypodium distachyon	38.51	2.00e-91	330.00
IUUC-Bol-015766	Brassica oleracea	34.32	8.00e-95	342.00
IUUC-Bra-017977	Brassica rapa	34.65	1.00e-94	341.00
IUUC-Cel-018129	Caenorhabditis elegans	29.56	4.00e-50	193.00
IUUC-Cja-019940	Callithrix jacchus	96.48	0.00e+00	1503.00
IUUC-Cfa-020113	Canis familiaris	94.53	0.00e+00	1407.00
IUUC-Cpo-021669	Cavia porcellus	96.19	0.00e+00	1495.00
IUUC-Cre-022990	Chlamydomonas reinhardtii	37.59	9.00e-25	108.00
IUUC-Csa-023060	Chlorocebus sabaeus	95.01	0.00e+00	1491.00
IUUC-Cin-025736	Ciona intestinalis	39.36	7.00e-107	381.00
IUUC-Csv-026175	Ciona savignyi	30.98	1.00e-22	99.40
IUUC-Cgl-026442	Colletotrichum gloeosporioides	34.30	2.00e-65	244.00
IUUC-Cne-026902	Cryptococcus neoformans	33.33	4.00e-66	246.00
IUUC-Cme-027318	Cyanidioschyzon merolae	26.93	1.00e-22	102.00
IUUC-Dre-028318	Danio rerio	54.17	0.00e+00	832.00
IUUC-Dno-029026	Dasypus novemcinctus	89.38	0.00e+00	1291.00
IUUC-Dor-031148	Dipodomys ordii	96.08	0.00e+00	1343.00
IUUC-Dse-031458	Dothistroma septosporum	30.87	6.00e-33	136.00
IUUC-Dme-032025	Drosophila melanogaster	38.85	2.00e-140	493.00
IUUC-Ete-033154	Echinops telfairi	88.79	0.00e+00	713.00
IUUC-Eca-033812	Equus caballus	96.81	0.00e+00	1194.00
IUUC-Eeu-035246	Erinaceus europaeus	90.69	7.00e-116	411.00
IUUC-Fca-035890	Felis catus	92.46	0.00e+00	1399.00
IUUC-Fal-037639	Ficedula albicollis	72.11	0.00e+00	997.00
IUUC-Fox-037792	Fusarium oxysporum	30.91	2.00e-59	224.00
IUUC-Fso-038191	Fusarium solani	30.23	1.00e-59	225.00
IUUC-Gmo-039138	Gadus morhua	61.57	0.00e+00	697.00
IUUC-Ggr-040106	Gaeumannomyces graminis	29.55	1.00e-47	185.00
IUUC-Gga-040327	Gallus gallus	71.41	0.00e+00	1019.00
IUUC-Gac-042053	Gasterosteus aculeatus	55.56	0.00e+00	674.00
IUUC-Gma-043658	Glycine max	29.36	1.00e-96	347.00
IUUC-Ggo-045094	Gorilla gorilla	99.76	0.00e+00	1564.00
IUUC-Hvu-047677	Hordeum vulgare	40.33	8.00e-79	288.00
IUUC-Itr-047927	Ictidomys tridecemlineatus	96.65	0.00e+00	1486.00
IUUC-Kpa-049177	Komagataella pastoris	32.52	5.00e-68	252.00
IUUC-Lch-049435	Latimeria chalumnae	64.16	0.00e+00	1025.00
IUUC-Lpe-050728	Leersia perrieri	35.02	2.00e-87	317.00
IUUC-Loc-052561	Lepisosteus oculatus	57.92	0.00e+00	865.00
IUUC-Lma-052995	Leptosphaeria maculans	30.24	3.00e-51	197.00
IUUC-Laf-053447	Loxodonta africana	95.09	0.00e+00	1479.00
IUUC-Mcc-054960	Macaca mulatta	99.39	0.00e+00	1561.00
IUUC-Meu-056836	Macropus eugenii	71.23	0.00e+00	1030.00
IUUC-Mor-057155	Magnaporthe oryzae	31.63	2.00e-52	201.00
IUUC-Mpo-057560	Magnaporthe poae	29.85	6.00e-52	199.00
IUUC-Mtr-058784	Medicago truncatula	31.17	2.00e-107	384.00
IUUC-Mla-058965	Melampsora laricipopulina	37.74	8.00e-61	228.00
IUUC-Mga-059511	Meleagris gallopavo	70.63	0.00e+00	1012.00
IUUC-Mvi-060393	Microbotryum violaceum	33.45	3.00e-78	286.00
IUUC-Mmr-061594	Microcebus murinus	96.06	0.00e+00	1492.00
IUUC-Mdo-063009	Monodelphis domestica	73.56	0.00e+00	1086.00
IUUC-Mmu-063535	Mus musculus	94.50	0.00e+00	1429.00
IUUC-Mac-065167	Musa acuminata	34.14	7.00e-97	348.00
IUUC-Mpu-065758	Mustela putorius furo	95.53	0.00e+00	1443.00
IUUC-Nfi-068614	Neosartorya fischeri	34.65	1.00e-69	258.00
IUUC-Ncr-068900	Neurospora crassa	30.71	3.00e-35	144.00
IUUC-Nle-069236	Nomascus leucogenys	92.02	0.00e+00	1386.00
IUUC-Opr-070724	Ochotona princeps	91.74	0.00e+00	794.00
IUUC-Ont-072662	Oreochromis niloticus	50.89	0.00e+00	730.00
IUUC-Oan-073106	Ornithorhynchus anatinus	53.06	5.00e-77	281.00
IUUC-Oba-075268	Oryza barthii	38.64	4.00e-84	306.00
IUUC-Obr-076594	Oryza brachyantha	38.52	2.00e-94	340.00
IUUC-Ogl-077092	Oryza glaberrima	39.15	5.00e-94	339.00
IUUC-Ogu-078791	Oryza glumaepatula	38.72	4.00e-84	306.00
IUUC-Oin-079065	Oryza indica	39.15	5.00e-94	339.00
IUUC-Olo-080300	Oryza longistaminata	38.69	8.00e-83	301.00
IUUC-Ome-081502	Oryza meridionalis	38.80	2.00e-84	307.00
IUUC-Oni-082212	Oryza nivara	38.64	4.00e-84	306.00
IUUC-Opu-083508	Oryza punctata	39.46	5.00e-88	319.00
IUUC-Oru-084815	Oryza rufipogon	38.51	3.00e-84	306.00
IUUC-Osa-085494	Oryza sativa	39.15	5.00e-94	339.00
IUUC-Ola-087495	Oryzias latipes	54.59	0.00e+00	800.00
IUUC-Olu-087578	Ostreococcus lucimarinus	34.98	4.00e-94	339.00
IUUC-Oga-088026	Otolemur garnettii	95.13	0.00e+00	1519.00
IUUC-Oar-089448	Ovis aries	67.85	0.00e+00	867.00
IUUC-Ptr-090626	Pan troglodytes	92.21	0.00e+00	1419.00
IUUC-Pan-092841	Papio anubis	99.39	0.00e+00	1561.00
IUUC-Psi-093519	Pelodiscus sinensis	68.89	3.00e-144	506.00
IUUC-Pno-094923	Phaeosphaeria nodorum	25.10	8.00e-26	112.00
IUUC-Ppa-095741	Physcomitrella patens	40.17	1.00e-64	241.00
IUUC-Pfo-096798	Poecilia formosa	51.84	0.00e+00	762.00
IUUC-Pab-097600	Pongo abelii	99.51	0.00e+00	1560.00
IUUC-Pop-099171	Populus trichocarpa	31.59	3.00e-103	369.00
IUUC-Pca-101085	Procavia capensis	88.94	0.00e+00	1364.00
IUUC-Ppe-101600	Prunus persica	39.59	3.00e-103	369.00
IUUC-Pva-102210	Pteropus vampyrus	94.16	0.00e+00	1471.00
IUUC-Pgr-103279	Puccinia graminis	38.74	8.00e-76	278.00
IUUC-Ptt-103707	Puccinia triticina	35.60	3.00e-62	233.00
IUUC-Pte-104344	Pyrenophora teres	28.55	5.00e-49	189.00
IUUC-Pyt-104781	Pyrenophora triticirepentis	37.35	2.00e-35	145.00
IUUC-Rno-104923	Rattus norvegicus	95.57	0.00e+00	1419.00
IUUC-Sce-106292	Saccharomyces cerevisiae	23.19	9.00e-22	99.40
IUUC-Sha-107256	Sarcophilus harrisii	74.24	0.00e+00	1068.00
IUUC-Sja-107869	Schizosaccharomyces japonicus	34.50	2.00e-70	260.00
IUUC-Spo-108218	Schizosaccharomyces pombe	29.55	2.00e-53	203.00
IUUC-Smo-108710	Selaginella moellendorffii	43.34	1.00e-75	277.00
IUUC-Sit-110252	Setaria italica	37.81	1.00e-89	325.00
IUUC-Sly-111678	Solanum lycopersicum	35.33	3.00e-98	353.00
IUUC-Stu-112740	Solanum tuberosum	35.68	3.00e-100	360.00
IUUC-Sbi-114620	Sorghum bicolor	39.91	7.00e-83	301.00
IUUC-Sre-115165	Sporisorium reilianum	33.02	4.00e-22	100.00
IUUC-Ssc-116411	Sus scrofa	72.46	1.00e-63	235.00
IUUC-Tgu-116996	Taeniopygia guttata	71.77	0.00e+00	1052.00
IUUC-Tru-118128	Takifugu rubripes	56.92	0.00e+00	802.00
IUUC-Tni-120443	Tetraodon nigroviridis	56.30	0.00e+00	752.00
IUUC-Tca-121062	Theobroma cacao	35.62	4.00e-97	349.00
IUUC-Tre-121916	Trichoderma reesei	32.09	2.00e-65	244.00
IUUC-Tvi-122395	Trichoderma virens	30.58	2.00e-58	221.00
IUUC-Tae-122865	Triticum aestivum	35.23	5.00e-92	332.00
IUUC-Tme-126929	Tuber melanosporum	33.88	5.00e-69	255.00
IUUC-Ttr-128180	Tursiops truncatus	88.79	0.00e+00	1366.00
IUUC-Uma-129453	Ustilago maydis	31.86	5.00e-33	136.00
IUUC-Vda-129887	Verticillium dahliae	39.17	4.00e-34	139.00
IUUC-Vvi-130919	Vitis vinifera	34.19	3.00e-99	356.00
IUUC-Xtr-132418	Xenopus tropicalis	67.36	0.00e+00	1040.00
IUUC-Xma-133612	Xiphophorus maculatus	61.92	0.00e+00	694.00
IUUC-Yli-134637	Yarrowia lipolytica	34.69	3.00e-69	256.00
IUUC-Zma-135885	Zea mays	39.22	3.00e-91	330.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence