iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000176871.8	ENST00000315436.7	ENSP00000319474.3
ENSG00000176871.8	ENST00000441406.6	ENSP00000409131.2
ENSG00000176871.8	ENST00000543218.5	ENSP00000438433.1
ENSG00000176871.8	ENST00000535496.5	ENSP00000439450.1
ENSG00000176871.8	ENST00000543186.1	ENSP00000445547.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Information
GWASdb
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	SOCS	17001306

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	2.20e-14	54.7	358	405
E3 adaptor/Cullin RING/DCX/DWD	1.30e-31	108.9	153	186
UBD/Beta-Prp	1.40e-45	157.4	127	362

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyed 51
           ++++w++++   SL+hLCR+a r++l+++++    +LP+Pk++k++L y++
   Q: 358  HVQFWTAPRVLSSLKHLCRKALRSFLTTYQV---LALPIPKKMKEFLTYRT 405
           689****************************...***************86 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlr 31
           gH+d v++l+f  s+  +lvs+s+D+t+++WDl 
   Q: 153  GHQDVVRDLSFtpSGsLILVSASRDKTLRIWDLN 186
           8***********6556779*************85 PP

UBD/Beta-Prp

   S: 24   llatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfspsgdklvsGs 113
           +latg  dg ik+w+v+tg ll  lsgh++ v++++f p+g+ ilv++s+D+t+++wdl+  gk++++l+gh + v+++s+sp+ + l s+ 
   Q: 127  VLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSlILVSASRDKTLRIWDLNkHGKQIQVLSGHLQWVYCCSISPDCSMLCSAA 218
           79****************************************9****************9789********************99******* PP
   S: 114  hdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl...........tgghtdsvyslsfdsngke 194
             + + +w +++++ ++  l+gh+++v +  ++pd+ llv++s+D+ v +Wd  tg+ lr l           +  h +s +s+ f+++g +
   Q: 219  GEKSVFLWSMRSYTLIR-KLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLhhtqvdpamddSDVHISSLRSVCFSPEGLY 309
           *****************.********************************************99999999888777888888888******* PP
   S: 195  lvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           l+++++d+ +++w l+ ++   +  +  +n ++  f+p++  +++g+ Dg +++W
   Q: 310  LATVADDRLLRIWALELKT--PIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFW 362
           ***************9885..7899****************************** PP

Organism

Homo sapiens

Functional Description
(View)

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MLSPAPEEPL LLAELKPGRP HQFDWKSSCE TWSVAFSPDG SWFAWSQGHC IVKLIPWPLE 60
EQFIPKGFEA KSRSSKNETK GRGSPKEKTL DCGQIVWGLA FSPWPSPPSR KLWARHHPQV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACTTGAATG AAGCTGACAC CAAGAACCGC GGGAAGAGCT TGGGCCCAAA GCAGGAAAGG 60
GAAGCGCTCG AGTTGGGGGT AAGGGGAGGC ATTTTGGGGA CAATGAGCTG AGCTCAGTAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR001496--SOCS_box
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50225--SOCS
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07525--SOCS_box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00253--SOCS
SM00969--SOCS_box
SM00320--WD40

Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

KEGG

hsa:55884

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002221	Ailuropoda melanoleuca	97.78	0.00e+00	819.00
IUUC-Apl-004107	Anas platyrhynchos	69.29	1.00e-131	462.00
IUUC-Aca-004354	Anolis carolinensis	73.63	5.00e-169	587.00
IUUC-Bta-012627	Bos taurus	98.77	0.00e+00	779.00
IUUC-Cja-018897	Callithrix jacchus	98.20	0.00e+00	784.00
IUUC-Cfa-020122	Canis familiaris	98.03	0.00e+00	820.00
IUUC-Cpo-022540	Cavia porcellus	97.54	0.00e+00	790.00
IUUC-Csa-023719	Chlorocebus sabaeus	99.74	0.00e+00	797.00
IUUC-Cho-024367	Choloepus hoffmanni	97.32	4.00e-172	596.00
IUUC-Dno-029021	Dasypus novemcinctus	98.28	0.00e+00	795.00
IUUC-Dor-030321	Dipodomys ordii	97.68	0.00e+00	786.00
IUUC-Ete-032955	Echinops telfairi	97.24	0.00e+00	780.00
IUUC-Eca-033485	Equus caballus	98.47	0.00e+00	768.00
IUUC-Fca-035389	Felis catus	98.20	0.00e+00	791.00
IUUC-Fal-037184	Ficedula albicollis	84.45	1.00e-142	499.00
IUUC-Gga-041014	Gallus gallus	77.00	2.00e-177	615.00
IUUC-Ggo-045585	Gorilla gorilla	100.00	0.00e+00	806.00
IUUC-Itr-049085	Ictidomys tridecemlineatus	97.94	0.00e+00	793.00
IUUC-Lch-050131	Latimeria chalumnae	69.76	6.00e-168	583.00
IUUC-Loc-052807	Lepisosteus oculatus	53.92	3.00e-117	415.00
IUUC-Laf-053528	Loxodonta africana	98.28	0.00e+00	776.00
IUUC-Mcc-055665	Macaca mulatta	100.00	0.00e+00	806.00
IUUC-Meu-056054	Macropus eugenii	87.88	0.00e+00	699.00
IUUC-Mga-059326	Meleagris gallopavo	77.44	0.00e+00	631.00
IUUC-Mmr-060815	Microcebus murinus	97.04	0.00e+00	787.00
IUUC-Mdo-062000	Monodelphis domestica	90.57	0.00e+00	748.00
IUUC-Mmu-063927	Mus musculus	96.14	0.00e+00	780.00
IUUC-Mpu-065726	Mustela putorius furo	96.40	0.00e+00	776.00
IUUC-Mlu-067527	Myotis lucifugus	97.14	2.00e-119	421.00
IUUC-Nle-069680	Nomascus leucogenys	99.49	0.00e+00	797.00
IUUC-Opr-070356	Ochotona princeps	97.74	0.00e+00	802.00
IUUC-Oan-073647	Ornithorhynchus anatinus	83.94	2.00e-136	478.00
IUUC-Ocu-073973	Oryctolagus cuniculus	97.29	0.00e+00	784.00
IUUC-Oga-088797	Otolemur garnettii	99.02	0.00e+00	795.00
IUUC-Oar-089187	Ovis aries	98.72	0.00e+00	778.00
IUUC-Ptr-091317	Pan troglodytes	100.00	0.00e+00	805.00
IUUC-Pan-092694	Papio anubis	91.95	0.00e+00	687.00
IUUC-Psi-093392	Pelodiscus sinensis	79.40	0.00e+00	642.00
IUUC-Pab-098145	Pongo abelii	99.74	0.00e+00	797.00
IUUC-Pca-100454	Procavia capensis	88.72	0.00e+00	720.00
IUUC-Pva-102986	Pteropus vampyrus	89.97	0.00e+00	729.00
IUUC-Rno-104931	Rattus norvegicus	94.85	0.00e+00	767.00
IUUC-Sha-106476	Sarcophilus harrisii	91.77	0.00e+00	746.00
IUUC-Ssc-115643	Sus scrofa	98.71	0.00e+00	790.00
IUUC-Tgu-117522	Taeniopygia guttata	64.53	4.00e-137	481.00
IUUC-Tsy-119301	Tarsius syrichta	99.50	0.00e+00	818.00
IUUC-Ttr-128683	Tursiops truncatus	98.71	0.00e+00	791.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence