iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046488

UUCD1 version

UUC-HoS-00345

Ensembl Protein ID

ENSP00000405574.1

UniProt Accession

Q9BZK7; D3DNQ9; Q14DC3; Q9H2I1; Q9H9A1; TBL1R_HUMAN

Genbank Protein ID

AAK00301.1; AAG44736.1; BAB14331.1; EAW78438.1; AAH60320.1; AAI13422.1

Protein Name

F-box-like/WD repeat-containing protein TBL1XR1; Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; TBL1-related protein 1; Transducin beta-like 1X-related protein 1

Genbank Nucleotide ID

AF314544; AF268193; AK022956; CH471052; BC060320; BC113421

Gene Name

TBL1XR1; IRA1; TBLR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000177565.16	ENST00000430069.5	ENSP00000405574.1
ENSG00000177565.16	ENST00000637659.1	ENSP00000490514.1
ENSG00000177565.16	ENST00000631253.2	ENSP00000486324.1
ENSG00000177565.16	ENST00000626758.1	ENSP00000486622.1
ENSG00000177565.16	ENST00000630796.2	ENSP00000486235.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	20547759; 19759827
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	20547759; 19759827

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.70e-53	177.8	347	385
UBD/Beta-Prp	1.90e-65	222.6	312	513

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHt++v+++++ ++ +ll+s+sdD t+k+W+++++++++
   Q: 347  GHTNEVNAIKWdPTgNLLASCSDDMTLKIWSMKQDNCVH 385
           8***********778*********************987 PP

UBD/Beta-Prp

   S: 14   tcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsp. 104
            +v++ ++++ +a+ s+d +i v ++ +   +++++gh++ev+a+k++p+g++l+++s+D+t+k+w++++  cvh l++h+++++++++sp 
   Q: 312  LDVDW-QSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPt 402
           44555.66777777777777777777777777777777777777777777777777777777777777777777777777777777777775 PP
   S: 105  .......sg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsf 188
                  +    l+s+s d+t+r+wd++ g c++ tl++h++ v +v+++pdg++l+sGs D++v +W+ +tg l++  +g  t+ +  + +
   Q: 403  gpgtnnpNAnLMLASASFDSTVRLWDVDRGICIH-TLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRG--TGGIFEVCW 491
           5555444222467777777777777777777777.7777777777777777777777777777777777777777777776..777777777 PP
   S: 189  dsngkelvsgsldgtvklwdlq 210
           +  g  + + + dg+v + dl+
   Q: 492  NAAGDKVGASASDGSVCVLDLR 513
           7777777777777777776665 PP

Organism

Homo sapiens

Functional Description
(View)

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.

Protein Sequence
(Fasta)

MSISSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GALVPPAALI SIIQKGLQYV 60
EAEVSINEDG TLFDGRPIES LSLIDAVMPD VVQTRQQAYR DKLAQQQAAA AAAAAAAASQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTTGCAGTG AGCTGAGATT GCACCATTGT GCTCCAATCT GGGCAACAAG AGCAAGACTC 60
TGTCTCAAAA ACAACAACAA CAAAAAAAAG TGATGTGACT GGCAGCACCC TATGCCTTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0010--Activator
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0991--Mental retardation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005876--C:spindle microtubule
GO:0017053--C:transcriptional repressor complex
GO:0008013--F:beta-catenin binding
GO:0042393--F:histone binding
GO:0047485--F:protein N-terminus binding
GO:0003714--F:transcription corepressor activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0060070--P:canonical Wnt signaling pathway
GO:0044255--P:cellular lipid metabolic process
GO:0060613--P:fat pad development
GO:0016575--P:histone deacetylation
GO:0016042--P:lipid catabolic process
GO:0035264--P:multicellular organism growth
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0030814--P:regulation of cAMP metabolic process
GO:0090207--P:regulation of triglyceride metabolic process
GO:0002021--P:response to dietary excess
GO:0006351--P:transcription, DNA-templated
GO:0050872--P:white fat cell differentiation

KEGG

hsa:79718

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000916	Aegilops tauschii	60.71	6.00e-55	206.00
IUUC-Aml-001717	Ailuropoda melanoleuca	98.83	0.00e+00	956.00
IUUC-Atr-002514	Amborella trichopoda	65.38	5.00e-145	508.00
IUUC-Apl-003708	Anas platyrhynchos	95.75	0.00e+00	911.00
IUUC-Aca-004611	Anolis carolinensis	95.91	0.00e+00	952.00
IUUC-Aly-005622	Arabidopsis lyrata	58.40	1.00e-119	424.00
IUUC-Ath-007137	Arabidopsis thaliana	59.50	4.00e-121	428.00
IUUC-Ago-007869	Ashbya gossypii	28.27	1.00e-32	134.00
IUUC-Ame-011601	Astyanax mexicanus	92.22	0.00e+00	904.00
IUUC-Bta-012418	Bos taurus	99.22	0.00e+00	980.00
IUUC-Bdi-014315	Brachypodium distachyon	60.42	1.00e-134	473.00
IUUC-Bol-016277	Brassica oleracea	57.25	5.00e-127	448.00
IUUC-Bra-016944	Brassica rapa	60.56	2.00e-126	446.00
IUUC-Cja-018832	Callithrix jacchus	99.81	0.00e+00	958.00
IUUC-Cfa-020029	Canis familiaris	99.03	0.00e+00	958.00
IUUC-Cpo-022080	Cavia porcellus	93.20	0.00e+00	913.00
IUUC-Cre-022979	Chlamydomonas reinhardtii	60.38	2.00e-130	459.00
IUUC-Csa-024075	Chlorocebus sabaeus	100.00	0.00e+00	958.00
IUUC-Cho-024872	Choloepus hoffmanni	99.15	5.00e-111	394.00
IUUC-Cin-025704	Ciona intestinalis	71.38	0.00e+00	790.00
IUUC-Csv-026257	Ciona savignyi	69.96	0.00e+00	759.00
IUUC-Cne-026946	Cryptococcus neoformans	38.01	2.00e-30	127.00
IUUC-Cme-027258	Cyanidioschyzon merolae	40.35	7.00e-106	377.00
IUUC-Dre-028075	Danio rerio	93.19	0.00e+00	924.00
IUUC-Dno-029196	Dasypus novemcinctus	99.61	0.00e+00	959.00
IUUC-Dor-030732	Dipodomys ordii	99.45	0.00e+00	732.00
IUUC-Eeu-034952	Erinaceus europaeus	89.61	0.00e+00	825.00
IUUC-Fca-035734	Felis catus	99.22	0.00e+00	958.00
IUUC-Fal-037185	Ficedula albicollis	96.11	0.00e+00	952.00
IUUC-Gmo-038870	Gadus morhua	90.47	0.00e+00	927.00
IUUC-Gga-041161	Gallus gallus	96.11	0.00e+00	953.00
IUUC-Gac-041844	Gasterosteus aculeatus	92.23	0.00e+00	954.00
IUUC-Gma-044208	Glycine max	48.34	3.00e-153	535.00
IUUC-Ggo-044882	Gorilla gorilla	100.00	0.00e+00	958.00
IUUC-Itr-047958	Ictidomys tridecemlineatus	100.00	0.00e+00	740.00
IUUC-Kpa-049338	Komagataella pastoris	28.91	9.00e-32	131.00
IUUC-Lch-050672	Latimeria chalumnae	96.70	0.00e+00	971.00
IUUC-Lpe-051084	Leersia perrieri	62.64	2.00e-136	479.00
IUUC-Loc-052030	Lepisosteus oculatus	95.95	0.00e+00	959.00
IUUC-Laf-054280	Loxodonta africana	98.83	0.00e+00	980.00
IUUC-Mcc-055203	Macaca mulatta	100.00	0.00e+00	957.00
IUUC-Meu-056563	Macropus eugenii	98.32	9.00e-135	473.00
IUUC-Mga-059660	Meleagris gallopavo	96.11	0.00e+00	953.00
IUUC-Mmr-060925	Microcebus murinus	97.80	0.00e+00	918.00
IUUC-Mdo-062078	Monodelphis domestica	98.25	0.00e+00	950.00
IUUC-Mmu-063603	Mus musculus	99.03	0.00e+00	954.00
IUUC-Mac-065508	Musa acuminata	61.80	3.00e-93	335.00
IUUC-Mpu-066741	Mustela putorius furo	99.03	0.00e+00	958.00
IUUC-Mlu-068152	Myotis lucifugus	99.42	0.00e+00	951.00
IUUC-Nle-069229	Nomascus leucogenys	100.00	0.00e+00	958.00
IUUC-Opr-070277	Ochotona princeps	88.56	0.00e+00	812.00
IUUC-Ont-072623	Oreochromis niloticus	92.43	0.00e+00	955.00
IUUC-Ocu-074280	Oryctolagus cuniculus	97.51	0.00e+00	949.00
IUUC-Obr-076718	Oryza brachyantha	62.91	7.00e-137	481.00
IUUC-Olo-080427	Oryza longistaminata	63.32	6.00e-132	464.00
IUUC-Ola-087365	Oryzias latipes	95.53	0.00e+00	952.00
IUUC-Oga-088357	Otolemur garnettii	94.36	0.00e+00	901.00
IUUC-Oar-089214	Ovis aries	99.42	0.00e+00	984.00
IUUC-Ptr-091532	Pan troglodytes	100.00	0.00e+00	958.00
IUUC-Pan-091927	Papio anubis	100.00	0.00e+00	958.00
IUUC-Psi-093941	Pelodiscus sinensis	92.60	0.00e+00	940.00
IUUC-Ppa-095868	Physcomitrella patens	65.16	9.00e-140	490.00
IUUC-Pfo-096158	Poecilia formosa	92.43	0.00e+00	954.00
IUUC-Pab-098705	Pongo abelii	100.00	0.00e+00	958.00
IUUC-Pop-098989	Populus trichocarpa	61.54	9.00e-128	450.00
IUUC-Pca-100256	Procavia capensis	99.02	0.00e+00	944.00
IUUC-Pva-102616	Pteropus vampyrus	99.01	0.00e+00	937.00
IUUC-Rno-105411	Rattus norvegicus	99.22	0.00e+00	957.00
IUUC-Sce-106132	Saccharomyces cerevisiae	24.78	2.00e-42	167.00
IUUC-Sha-106636	Sarcophilus harrisii	98.06	0.00e+00	950.00
IUUC-Smo-109301	Selaginella moellendorffii	63.49	9.00e-143	500.00
IUUC-Sit-110710	Setaria italica	63.71	2.00e-142	499.00
IUUC-Sly-111042	Solanum lycopersicum	50.68	4.00e-150	525.00
IUUC-Stu-112744	Solanum tuberosum	49.90	2.00e-141	496.00
IUUC-Sar-112971	Sorex araneus	90.20	0.00e+00	866.00
IUUC-Sbi-114420	Sorghum bicolor	63.19	3.00e-142	498.00
IUUC-Sre-115175	Sporisorium reilianum	37.92	1.00e-57	218.00
IUUC-Ssc-115695	Sus scrofa	97.67	0.00e+00	936.00
IUUC-Tgu-117009	Taeniopygia guttata	96.05	0.00e+00	936.00
IUUC-Tru-118581	Takifugu rubripes	95.34	0.00e+00	956.00
IUUC-Tsy-119424	Tarsius syrichta	82.05	0.00e+00	725.00
IUUC-Tni-119986	Tetraodon nigroviridis	95.53	0.00e+00	956.00
IUUC-Tca-121739	Theobroma cacao	54.08	7.00e-125	441.00
IUUC-Tme-127126	Tuber melanosporum	38.42	3.00e-58	219.00
IUUC-Tbe-127665	Tupaia belangeri	82.46	0.00e+00	820.00
IUUC-Vpa-130768	Vicugna pacos	99.61	0.00e+00	944.00
IUUC-Xtr-132842	Xenopus tropicalis	89.96	0.00e+00	902.00
IUUC-Xma-134020	Xiphophorus maculatus	92.43	0.00e+00	954.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence