iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tgu-117009

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABQF01023231

Gene Name

TBL1XR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000010773.1	ENSTGUT00000011229.1	ENSTGUP00000011109.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.80e-51	169.0	347	385
UBD/Beta-Prp	6.20e-65	219.1	307	483

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHt++v+++++ ++ +ll+s+sdD t+k+W+++++ +++
   Q: 347  GHTNEVNAIKWdPTgNLLASCSDDMTLKIWSMKQDSCVH 385
           8***********778********************9986 PP

UBD/Beta-Prp

   S: 93   hedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtd 181
           h++ +l+++++  +++++s s d  i+v +l ++  ++ t++gh+  vn ++++p+gnll+s+s+D t+++W++k+++++++l+  h++
   Q: 307  HSAPALDVDWQS-NNTFASCSTDMCIHVCKLGQDRPIK-TFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDSCVHDLQA-HNK 392
           667777888877.7889999999999999999999998.9999999999999999999999999999999999999999999987.999 PP
   S: 182  svyslsfdsng.........kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlq 261
            +y ++++++g           l+s+s d+tv+lwd+ +g c++tl+ h+++v+sv+fsp++ +l+sgs D+ + iW++++g l++++ 
   Q: 393  EIYTIKWSPTGpgtnnpnanLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYR 481
           99999999998999999888888899999999999999999999999999999999999999999999999999999999999888877 PP
   S: 262  lh 263
           ++
   Q: 482  GT 483
           65 PP

Organism

Taeniopygia guttata

Protein Sequence
(Fasta)

KMSISSDEVN FLVYRYLQES GFSHSAFTFG IESHISQSNI NGALVPPAAL ISIIQKGLQY 60
VEAEVSINED GTLFDGRPIE SLSLIDAVMP DVVQTRQQAY RDKLAQQQAA AAAAAAATNQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGATGAGTA TAAGCAGTGA TGAGGTTAAC TTCCTGGTAT ATAGATACTT GCAAGAGTCA 60
GGTGAGTTTT TACACTTCTG ATTATTAAAC AATGCATAAT TTATTTCATC TTCATCTGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0005876--C:spindle microtubule
GO:0017053--C:transcriptional repressor complex
GO:0003714--F:transcription corepressor activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0060070--P:canonical Wnt signaling pathway
GO:0060613--P:fat pad development
GO:0016042--P:lipid catabolic process
GO:0035264--P:multicellular organism growth
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0030814--P:regulation of cAMP metabolic process
GO:0090207--P:regulation of triglyceride metabolic process
GO:0002021--P:response to dietary excess
GO:0050872--P:white fat cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001717	Ailuropoda melanoleuca	95.45	0.00e+00	938.00
IUUC-Apl-003708	Anas platyrhynchos	99.79	0.00e+00	915.00
IUUC-Aca-004611	Anolis carolinensis	99.21	0.00e+00	950.00
IUUC-Ame-011601	Astyanax mexicanus	89.90	0.00e+00	889.00
IUUC-Bta-012418	Bos taurus	99.21	0.00e+00	972.00
IUUC-Cja-018832	Callithrix jacchus	99.01	0.00e+00	944.00
IUUC-Cfa-020029	Canis familiaris	95.26	0.00e+00	937.00
IUUC-Cpo-022080	Cavia porcellus	94.28	0.00e+00	910.00
IUUC-Csa-024075	Chlorocebus sabaeus	95.85	0.00e+00	937.00
IUUC-Cho-024872	Choloepus hoffmanni	98.29	2.00e-111	395.00
IUUC-Dre-028075	Danio rerio	96.44	0.00e+00	919.00
IUUC-Dno-029196	Dasypus novemcinctus	99.61	0.00e+00	954.00
IUUC-Dor-030732	Dipodomys ordii	99.17	0.00e+00	730.00
IUUC-Eeu-034952	Erinaceus europaeus	89.33	0.00e+00	822.00
IUUC-Fca-035734	Felis catus	99.01	0.00e+00	949.00
IUUC-Fal-037185	Ficedula albicollis	99.80	0.00e+00	954.00
IUUC-Gmo-038870	Gadus morhua	90.50	0.00e+00	915.00
IUUC-Gga-041161	Gallus gallus	100.00	0.00e+00	957.00
IUUC-Gac-041844	Gasterosteus aculeatus	92.31	0.00e+00	941.00
IUUC-Ggo-044882	Gorilla gorilla	95.85	0.00e+00	937.00
IUUC-Hsa-046488	Homo sapiens	95.85	0.00e+00	937.00
IUUC-Itr-047958	Ictidomys tridecemlineatus	99.72	0.00e+00	723.00
IUUC-Kpa-049338	Komagataella pastoris	28.52	2.00e-31	129.00
IUUC-Lch-050672	Latimeria chalumnae	96.06	0.00e+00	955.00
IUUC-Loc-052030	Lepisosteus oculatus	95.29	0.00e+00	948.00
IUUC-Laf-054280	Loxodonta africana	98.81	0.00e+00	971.00
IUUC-Mcc-055203	Macaca mulatta	95.86	0.00e+00	939.00
IUUC-Meu-056563	Macropus eugenii	98.74	1.00e-135	475.00
IUUC-Mga-059660	Meleagris gallopavo	100.00	0.00e+00	957.00
IUUC-Mmr-060925	Microcebus murinus	97.57	0.00e+00	901.00
IUUC-Mdo-062078	Monodelphis domestica	98.82	0.00e+00	947.00
IUUC-Mmu-063603	Mus musculus	99.01	0.00e+00	947.00
IUUC-Mac-065508	Musa acuminata	61.80	1.00e-93	336.00
IUUC-Mpu-066741	Mustela putorius furo	95.26	0.00e+00	937.00
IUUC-Mlu-068152	Myotis lucifugus	99.41	0.00e+00	944.00
IUUC-Nle-069229	Nomascus leucogenys	95.85	0.00e+00	937.00
IUUC-Opr-070277	Ochotona princeps	88.54	0.00e+00	815.00
IUUC-Ont-072623	Oreochromis niloticus	92.31	0.00e+00	941.00
IUUC-Ocu-074280	Oryctolagus cuniculus	97.48	0.00e+00	941.00
IUUC-Oin-079515	Oryza indica	44.12	1.00e-94	340.00
IUUC-Ola-087365	Oryzias latipes	95.28	0.00e+00	941.00
IUUC-Oga-088357	Otolemur garnettii	95.25	0.00e+00	889.00
IUUC-Oar-089214	Ovis aries	99.41	0.00e+00	977.00
IUUC-Ptr-091532	Pan troglodytes	95.85	0.00e+00	937.00
IUUC-Pan-091927	Papio anubis	95.85	0.00e+00	937.00
IUUC-Psi-093941	Pelodiscus sinensis	92.49	0.00e+00	922.00
IUUC-Pma-094105	Petromyzon marinus	63.49	4.00e-101	360.00
IUUC-Pfo-096158	Poecilia formosa	92.11	0.00e+00	941.00
IUUC-Pab-098705	Pongo abelii	95.85	0.00e+00	937.00
IUUC-Pca-100256	Procavia capensis	98.62	0.00e+00	942.00
IUUC-Ppe-101572	Prunus persica	64.62	5.00e-128	451.00
IUUC-Pva-102616	Pteropus vampyrus	99.01	0.00e+00	946.00
IUUC-Rno-105411	Rattus norvegicus	99.21	0.00e+00	949.00
IUUC-Sce-106132	Saccharomyces cerevisiae	25.36	4.00e-42	165.00
IUUC-Sha-106636	Sarcophilus harrisii	98.43	0.00e+00	942.00
IUUC-Stu-112786	Solanum tuberosum	48.54	1.00e-142	499.00
IUUC-Sar-112971	Sorex araneus	87.35	0.00e+00	862.00
IUUC-Sre-115175	Sporisorium reilianum	37.17	4.00e-58	219.00
IUUC-Ssc-115695	Sus scrofa	97.63	0.00e+00	929.00
IUUC-Tru-118581	Takifugu rubripes	95.46	0.00e+00	942.00
IUUC-Tsy-119424	Tarsius syrichta	82.02	0.00e+00	733.00
IUUC-Tni-119986	Tetraodon nigroviridis	95.66	0.00e+00	946.00
IUUC-Tur-126856	Triticum urartu	60.61	5.00e-62	231.00
IUUC-Tme-127126	Tuber melanosporum	38.42	1.00e-58	219.00
IUUC-Tbe-127665	Tupaia belangeri	84.36	0.00e+00	825.00
IUUC-Vpa-130768	Vicugna pacos	95.85	0.00e+00	938.00
IUUC-Xtr-132842	Xenopus tropicalis	93.04	0.00e+00	903.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence