iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
microRNA	TRANSFAC	TargetScan	RepTar
miRNAMap	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	dbPTM	BioGRID
mUbiSiDa
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UBL/SUMO	SUMO	15247916

Classification

Family	E-value	Score	Start	End
ULD/UBL/SUMO	8.50e-30	105.0	14	93

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/SUMO

   S: 5    fkapvslkvagqdGsevlfklklsaqlkklmeavYvkrinldensvrfvfngqkireqetpeelevededkiellcqksGG 85
           +  +++lkvagqdGs v+fk+k++++l+klm+a Y+++++l+++++rf+f+gq+i+ +++p++le+eded+i++++q +GG
   Q: 14   NNNHINLKVAGQDGSVVQFKIKRQTPLSKLMKA-YCEPRGLSVKQIRFRFGGQPISGTDKPAQLEMEDEDTIDVFQQPTGG 93
           789******************************.**********************************************9 PP

Organism

Homo sapiens

Functional Description
(View)

Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I.

Protein Sequence
(Fasta)

MANEKPTEEV KTENNNHINL KVAGQDGSVV QFKIKRQTPL SKLMKAYCEP RGLSVKQIRF 60
RFGGQPISGT DKPAQLEMED EDTIDVFQQP TGGVY 95

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Nucleotide Sequence
(Fasta)

CTGGCGCACA CAGCGGGAGG GGAGGGAGCC CAGGATGTGC ACGCACCCTC TCCCTCATCC 60
ACCGCTGTCA CCTCCTGCTG CTCTTCCTGC TGCTCGTGTA CTCGTTAGGT GCGGACCCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR022617--Rad60/SUMO-like_dom
IPR033950--Sumo
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF11976--Rad60-SLD

SMART

SM00213--UBQ

Gene Ontology

GO:0005634--C:nucleus
GO:0031386--F:protein tag
GO:0016925--P:protein sumoylation

KEGG

hsa:387082

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ath-006791	Arabidopsis thaliana	41.49	5.00e-17	79.30
IUUC-Dor-030760	Dipodomys ordii	33.77	2.00e-06	46.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence