iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000177981.10	ENST00000317697.7	ENSP00000320893.3
ENSG00000177981.10	ENST00000536953.5	ENSP00000438498.1
ENSG00000177981.10	ENST00000539865.5	ENSP00000438434.1
ENSG00000177981.10	ENST00000536071.5	ENSP00000442737.1
ENSG00000177981.10	ENST00000540143.5	ENSP00000443835.1
ENSG00000177981.10	ENST00000540782.1	ENSP00000437530.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	SOCS	12559969

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	3.00e-14	54.3	238	286

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrl.kaidkLPLPksLkdYLly 49
           +kl++l+s p +L++L R+a+rr+lg q l +a+++LPLP sLk+YLl 
   Q: 238  EKLTVLCSAPGTLKTLARYAVRRSLGLQYLpDAVKGLPLPASLKEYLLL 286
           7899*******************************************96 PP

Organism

Homo sapiens

Functional Description
(View)

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MSSSMWYIMQ SIQSKYSLSE RLIRTIAAIR SFPHDNVEDL IRGGADVNCT HGTLKPLHCA 60
CMVSDADCVE LLLEKGAEVN ALDGYNRTAL HYAAEKDEAC VEVLLEYGAN PNALDGNRDT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAATTATTG GAGAAGCACA AAAGGCCATG GGAAACATGT GCAGAGATCA AGCAGTTTGG 60
CTGGTCCAGT CAAGTTCCAG GTCAAACATT TGAGAGCCAA GGGTAGGTGG GAACTGGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001496--SOCS_box

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50225--SOCS

Pfam

PF12796--Ank_2
PF07525--SOCS_box

SMART

SM00248--ANK
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

KEGG

hsa:140461

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001601	Ailuropoda melanoleuca	98.61	5.00e-168	583.00
IUUC-Apl-003898	Anas platyrhynchos	84.02	4.00e-123	433.00
IUUC-Aca-005321	Anolis carolinensis	90.21	6.00e-156	543.00
IUUC-Ame-010739	Astyanax mexicanus	79.79	5.00e-129	453.00
IUUC-Bta-013314	Bos taurus	98.26	1.00e-167	582.00
IUUC-Cja-018726	Callithrix jacchus	98.96	2.00e-168	584.00
IUUC-Cfa-020084	Canis familiaris	98.61	5.00e-168	583.00
IUUC-Cpo-022509	Cavia porcellus	97.92	2.00e-167	580.00
IUUC-Csa-023640	Chlorocebus sabaeus	100.00	3.00e-170	590.00
IUUC-Cho-024844	Choloepus hoffmanni	98.61	5.00e-168	583.00
IUUC-Cin-025183	Ciona intestinalis	37.42	1.00e-19	91.70
IUUC-Dre-027663	Danio rerio	79.44	4.00e-133	467.00
IUUC-Dno-029623	Dasypus novemcinctus	98.26	1.00e-167	581.00
IUUC-Dor-030857	Dipodomys ordii	97.22	5.00e-166	576.00
IUUC-Eca-033273	Equus caballus	98.26	1.00e-167	582.00
IUUC-Eeu-034981	Erinaceus europaeus	97.57	2.00e-166	578.00
IUUC-Fca-035934	Felis catus	98.61	5.00e-168	583.00
IUUC-Fal-037472	Ficedula albicollis	83.22	2.00e-137	481.00
IUUC-Gmo-038873	Gadus morhua	77.51	3.00e-131	460.00
IUUC-Gga-041086	Gallus gallus	86.22	2.00e-147	514.00
IUUC-Gac-041583	Gasterosteus aculeatus	79.09	7.00e-134	469.00
IUUC-Ggo-044756	Gorilla gorilla	100.00	3.00e-170	590.00
IUUC-Itr-048325	Ictidomys tridecemlineatus	97.92	5.00e-167	579.00
IUUC-Lch-050156	Latimeria chalumnae	83.97	2.00e-147	514.00
IUUC-Laf-053574	Loxodonta africana	98.26	4.00e-167	580.00
IUUC-Mcc-054710	Macaca mulatta	97.30	7.00e-168	582.00
IUUC-Meu-056561	Macropus eugenii	95.83	2.00e-163	567.00
IUUC-Mga-059733	Meleagris gallopavo	85.25	3.00e-125	440.00
IUUC-Mmr-060632	Microcebus murinus	98.26	1.00e-167	582.00
IUUC-Mmu-064371	Mus musculus	97.22	2.00e-165	574.00
IUUC-Mpu-066066	Mustela putorius furo	98.26	2.00e-167	581.00
IUUC-Mlu-067200	Myotis lucifugus	98.61	5.00e-168	583.00
IUUC-Nle-069782	Nomascus leucogenys	100.00	3.00e-170	590.00
IUUC-Opr-070962	Ochotona princeps	95.14	4.00e-163	566.00
IUUC-Ont-071639	Oreochromis niloticus	79.79	8.00e-130	456.00
IUUC-Oan-072927	Ornithorhynchus anatinus	79.21	3.00e-73	267.00
IUUC-Ocu-074106	Oryctolagus cuniculus	95.45	1.00e-162	565.00
IUUC-Ola-086720	Oryzias latipes	79.09	1.00e-128	452.00
IUUC-Oga-088635	Otolemur garnettii	98.61	5.00e-168	583.00
IUUC-Oar-090018	Ovis aries	98.26	1.00e-167	582.00
IUUC-Ptr-091388	Pan troglodytes	99.65	8.00e-170	589.00
IUUC-Pan-092014	Papio anubis	100.00	3.00e-170	590.00
IUUC-Psi-093909	Pelodiscus sinensis	86.76	4.00e-150	523.00
IUUC-Pfo-096383	Poecilia formosa	78.40	2.00e-128	451.00
IUUC-Pab-097714	Pongo abelii	97.87	7.00e-162	562.00
IUUC-Pva-103230	Pteropus vampyrus	97.96	9.00e-141	492.00
IUUC-Rno-104942	Rattus norvegicus	97.92	2.00e-166	577.00
IUUC-Sha-106733	Sarcophilus harrisii	97.22	1.00e-165	575.00
IUUC-Ssc-116033	Sus scrofa	98.26	1.00e-167	582.00
IUUC-Tgu-117411	Taeniopygia guttata	86.36	3.00e-143	500.00
IUUC-Tru-118207	Takifugu rubripes	77.70	7.00e-127	446.00
IUUC-Tsy-119535	Tarsius syrichta	73.96	3.00e-111	394.00
IUUC-Tni-120699	Tetraodon nigroviridis	78.05	5.00e-127	446.00
IUUC-Tbe-127600	Tupaia belangeri	97.96	3.00e-140	490.00
IUUC-Ttr-128818	Tursiops truncatus	97.57	5.00e-167	579.00
IUUC-Vpa-130323	Vicugna pacos	98.26	1.00e-167	582.00
IUUC-Xtr-132195	Xenopus tropicalis	64.77	3.00e-91	328.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence