iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000178222.12	ENST00000506730.5	ENSP00000425843.1
ENSG00000178222.12	ENST00000382968.9	ENSP00000372428.5
ENSG00000178222.12	ENST00000433731.6	ENSP00000389709.2
ENSG00000178222.12	ENST00000511620.5	ENSP00000426115.1
ENSG00000178222.12	ENST00000510715.5	ENSP00000423560.1
ENSG00000178222.12	ENST00000333673.5	ENSP00000327481.5

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
Mentha
Disease-associated Variation
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	76.17	2.00e-83	305.00	IUUC-Mmu-063236

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Homo sapiens

Functional Description
(View)

SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination (By similarity).

Protein Sequence
(Fasta)

MANWVFCNRC FQPPHRTSCF SLTNCGHVYC DACLGKGKKN ECLICKAPCR TVLLSKHTDA 60
DIQAFFMSID SLCKKYSRET SQILEFQEKH RKRLLAFYRE KISRLEESLR KSVLQIEQLQ 120

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Nucleotide Sequence
(Fasta)

AGAGCTGCCC GCCTTCGGGC CCTGCGCGGG GAGGCTGGTC CCAACCTTGC GTGGGCTTCG 60
CGTGGGCCCG GCCTCGCCGC TGCGGTCGCC CGCCTGGCAT GGCCAACTGG GTGTTCTGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0436--Ligase
KW-0469--Meiosis
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF14634--zf-RING_5

Gene Ontology

GO:0000795--C:synaptonemal complex
GO:0016874--F:ligase activity
GO:0019789--F:SUMO transferase activity
GO:0008270--F:zinc ion binding
GO:0051026--P:chiasma assembly
GO:0006311--P:meiotic gene conversion
GO:0016925--P:protein sumoylation
GO:0007131--P:reciprocal meiotic recombination
GO:0007129--P:synapsis

KEGG

hsa:285498

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001870	Ailuropoda melanoleuca	78.76	3.00e-88	317.00
IUUC-Apl-003243	Anas platyrhynchos	52.94	3.00e-54	204.00
IUUC-Cja-019749	Callithrix jacchus	75.84	9.00e-122	429.00
IUUC-Cfa-021065	Canis familiaris	74.49	8.00e-82	296.00
IUUC-Cpo-021724	Cavia porcellus	78.05	8.00e-37	144.00
IUUC-Csa-023944	Chlorocebus sabaeus	88.70	8.00e-145	506.00
IUUC-Dre-028619	Danio rerio	42.99	3.00e-22	98.60
IUUC-Fal-036889	Ficedula albicollis	47.55	1.00e-46	179.00
IUUC-Gga-041126	Gallus gallus	54.90	2.00e-56	212.00
IUUC-Ggo-045115	Gorilla gorilla	97.98	2.00e-173	601.00
IUUC-Lch-049607	Latimeria chalumnae	40.82	7.00e-47	181.00
IUUC-Loc-052360	Lepisosteus oculatus	43.70	2.00e-31	127.00
IUUC-Mcc-055392	Macaca mulatta	95.83	7.00e-107	380.00
IUUC-Mga-060189	Meleagris gallopavo	52.69	2.00e-42	164.00
IUUC-Mdo-062424	Monodelphis domestica	66.67	4.00e-65	241.00
IUUC-Mmu-063236	Mus musculus	76.17	2.00e-84	305.00
IUUC-Mpu-066050	Mustela putorius furo	78.57	3.00e-87	315.00
IUUC-Nle-069489	Nomascus leucogenys	92.25	5.00e-133	466.00
IUUC-Oan-073698	Ornithorhynchus anatinus	55.44	4.00e-53	200.00
IUUC-Ocu-073927	Oryctolagus cuniculus	77.71	1.00e-68	251.00
IUUC-Ola-087241	Oryzias latipes	32.77	2.00e-20	91.30
IUUC-Ptr-091122	Pan troglodytes	98.30	1.00e-169	588.00
IUUC-Pan-092892	Papio anubis	94.79	8.00e-106	376.00
IUUC-Pab-097611	Pongo abelii	97.93	1.00e-109	389.00
IUUC-Rno-105151	Rattus norvegicus	75.65	1.00e-85	309.00
IUUC-Sha-107525	Sarcophilus harrisii	63.73	9.00e-67	246.00
IUUC-Tgu-116643	Taeniopygia guttata	50.99	8.00e-53	199.00
IUUC-Tbe-127755	Tupaia belangeri	43.30	3.00e-38	151.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence