iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000178498.15	ENST00000548804.5	ENSP00000449294.1
ENSG00000178498.15	ENST00000551632.1	ENSP00000448696.1
ENSG00000178498.15	ENST00000550300.1	ENSP00000446996.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
RepTar	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	12670957

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.0002	23.4	164	202

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlp.CgHvfhadClqkwpglknssskefrCPlC 45
           C+iCl ++++  ++l  C H f++ C+ +        + +  CP C
   Q: 164  CPICLGEIQN-AKTLEkCRHSFCEGCITRA------LQVKKACPMC 202
           ********99.555445**********888......888889**** PP

Organism

Homo sapiens

Functional Description
(View)

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.

Protein Sequence
(Fasta)

MSFVLSRMAA CGGTCKNKVT VSKPVWDFLS KETPARLARL REEHRVSILI DGETSDIYVL 60
QLSPQGPPPA PPNGLYLARK ALKGLLKEAE KELKKAQRQG ELMGCLALGG GGEHPEMHRA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CATTTTTGTT TTGGGGAGGA AGGGCAGGGG CTTGCGGATA GAAGGGGGTC AAAGGAACGG 60
TGATTATCAC CTGTGAGGGG AAAGGGGGTG CTGTCCTCCC TCCTTCCCTT TTCCTCAGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0914--Notch signaling pathway
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0007219--P:Notch signaling pathway
GO:0016567--P:protein ubiquitination

KEGG

hsa:196403

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001955	Ailuropoda melanoleuca	89.63	1.00e-146	512.00
IUUC-Aca-004581	Anolis carolinensis	73.71	8.00e-132	462.00
IUUC-Ame-010892	Astyanax mexicanus	45.71	8.00e-77	280.00
IUUC-Bta-013176	Bos taurus	98.56	4.00e-159	553.00
IUUC-Cja-020011	Callithrix jacchus	99.71	3.00e-161	561.00
IUUC-Csa-023491	Chlorocebus sabaeus	99.71	1.00e-160	559.00
IUUC-Dre-027528	Danio rerio	45.33	8.00e-79	287.00
IUUC-Dor-030132	Dipodomys ordii	99.20	4.00e-99	353.00
IUUC-Eca-034031	Equus caballus	99.42	8.00e-161	559.00
IUUC-Fca-035841	Felis catus	90.20	3.00e-150	524.00
IUUC-Gmo-039399	Gadus morhua	66.14	1.00e-74	272.00
IUUC-Gac-041788	Gasterosteus aculeatus	68.25	6.00e-77	280.00
IUUC-Itr-048095	Ictidomys tridecemlineatus	99.38	5.00e-145	506.00
IUUC-Lch-049613	Latimeria chalumnae	49.28	2.00e-90	325.00
IUUC-Loc-052211	Lepisosteus oculatus	66.67	5.00e-74	271.00
IUUC-Laf-054581	Loxodonta africana	97.52	2.00e-136	478.00
IUUC-Mcc-054728	Macaca mulatta	99.71	1.00e-160	559.00
IUUC-Meu-056607	Macropus eugenii	91.49	2.00e-56	213.00
IUUC-Mmr-061590	Microcebus murinus	98.85	8.00e-160	556.00
IUUC-Mmu-063092	Mus musculus	98.56	1.00e-159	555.00
IUUC-Mlu-067304	Myotis lucifugus	98.85	1.00e-159	555.00
IUUC-Nle-069146	Nomascus leucogenys	99.71	4.00e-162	563.00
IUUC-Opr-070349	Ochotona princeps	96.25	9.00e-153	532.00
IUUC-Ont-072659	Oreochromis niloticus	68.78	3.00e-77	281.00
IUUC-Oan-073678	Ornithorhynchus anatinus	59.44	3.00e-62	230.00
IUUC-Ocu-074233	Oryctolagus cuniculus	99.41	1.00e-154	538.00
IUUC-Ola-086410	Oryzias latipes	62.33	3.00e-51	193.00
IUUC-Oga-088601	Otolemur garnettii	98.55	5.00e-159	553.00
IUUC-Oar-089267	Ovis aries	90.49	1.00e-157	548.00
IUUC-Ptr-090762	Pan troglodytes	99.69	1.00e-145	509.00
IUUC-Pan-092025	Papio anubis	100.00	3.00e-161	561.00
IUUC-Pma-094498	Petromyzon marinus	56.15	5.00e-61	227.00
IUUC-Ppa-095323	Physcomitrella patens	49.74	3.00e-49	189.00
IUUC-Pfo-096782	Poecilia formosa	42.44	7.00e-65	241.00
IUUC-Pab-098746	Pongo abelii	96.36	2.00e-93	335.00
IUUC-Pva-102316	Pteropus vampyrus	98.27	2.00e-157	548.00
IUUC-Rno-105615	Rattus norvegicus	98.56	1.00e-159	555.00
IUUC-Sha-107204	Sarcophilus harrisii	95.10	1.00e-155	542.00
IUUC-Ssc-115485	Sus scrofa	99.13	2.00e-157	548.00
IUUC-Tru-118523	Takifugu rubripes	67.91	4.00e-75	274.00
IUUC-Tni-120280	Tetraodon nigroviridis	68.98	7.00e-76	276.00
IUUC-Ttr-128361	Tursiops truncatus	98.27	5.00e-157	546.00
IUUC-Xtr-131966	Xenopus tropicalis	72.65	6.00e-132	463.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence