iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000180353.10	ENST00000314583.7	ENSP00000320176.3
ENSG00000180353.10	ENST00000428394.6	ENSP00000387645.2
ENSG00000180353.10	ENST00000495491.5	ENSP00000418299.1
ENSG00000180353.10	ENST00000464274.5	ENSP00000420507.1
ENSG00000180353.10	ENST00000497391.5	ENSP00000419614.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	PhosphoBase
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.40e-11	44.6	434	485

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
            + ydy+++ +deL++   dv++ i  e  degW++g    +g  GlfP+n+v+ l
   Q: 434  VAVYDYQGEGSDELSFDPDDVITDI--EMVDEGWWRG--RCHGHFGLFPANYVKLL 485
           589*********************9..9*********..8*************977 PP

Organism

Homo sapiens

Functional Description
(View)

Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively, while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN, but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1, through binding to its C-terminal region. Interacts with HS1BP3. Interacts with FES/FPS (By similarity). Interacts (via SH2 domain) with FGR. Forms a multiprotein complex with LYN and ANKRD54 (By similarity).

Protein Sequence
(Fasta)

MWKSVVGHDV SVSVETQGDD WDTDPDFVND ISEKEQRWGA KTIEGSGRTE HINIHQLRNK 60
VSEEHDVLRK KEMESGPKAS HGYGGRFGVE RDRMDKSAVG HEYVAEVEKH SSQTDAAKGF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTGAAGCAG CAGCTCAGTT TCTCACTCCG AAGTGGCAGC AGCCAGAGAG GGAGTCGGTG 60
TGGACGCGAG GAGCCGGGCG CTTAGAACAG AGGCTTGCAC AGGTGGAGGT GGGTACTCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0472--Membrane
KW-0496--Mitochondrion
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain

Interpro

IPR028534--HS1
IPR003134--Hs1_Cortactin
IPR001452--SH3_domain

PROSITE

PS51090--CORTACTIN
PS50002--SH3

Pfam

PF02218--HS1_rep
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005667--C:transcription factor complex
GO:0019901--F:protein kinase binding
GO:0001085--F:RNA polymerase II transcription factor binding
GO:0030041--P:actin filament polymerization
GO:0071345--P:cellular response to cytokine stimulus
GO:0030218--P:erythrocyte differentiation
GO:0035556--P:intracellular signal transduction
GO:2000107--P:negative regulation of leukocyte apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:2000251--P:positive regulation of actin cytoskeleton reorganization
GO:0008284--P:positive regulation of cell proliferation
GO:0030854--P:positive regulation of granulocyte differentiation
GO:0045651--P:positive regulation of macrophage differentiation
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0042993--P:positive regulation of transcription factor import into nucleus
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0042531--P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0030833--P:regulation of actin filament polymerization
GO:0006355--P:regulation of transcription, DNA-templated
GO:0009725--P:response to hormone

KEGG

hsa:3059

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001194	Ailuropoda melanoleuca	83.13	0.00e+00	720.00
IUUC-Bta-012591	Bos taurus	86.73	0.00e+00	672.00
IUUC-Cja-019982	Callithrix jacchus	88.78	0.00e+00	718.00
IUUC-Cfa-020262	Canis familiaris	80.97	0.00e+00	637.00
IUUC-Cpo-021362	Cavia porcellus	82.72	0.00e+00	632.00
IUUC-Csa-023911	Chlorocebus sabaeus	97.45	0.00e+00	637.00
IUUC-Dor-030437	Dipodomys ordii	76.08	2.00e-168	585.00
IUUC-Ete-033160	Echinops telfairi	75.98	6.00e-154	537.00
IUUC-Eca-033269	Equus caballus	84.27	0.00e+00	711.00
IUUC-Eeu-035032	Erinaceus europaeus	71.21	6.00e-122	431.00
IUUC-Fca-035999	Felis catus	82.14	0.00e+00	746.00
IUUC-Ggo-044505	Gorilla gorilla	93.42	0.00e+00	754.00
IUUC-Itr-048592	Ictidomys tridecemlineatus	66.91	4.00e-163	567.00
IUUC-Laf-054202	Loxodonta africana	80.93	0.00e+00	650.00
IUUC-Mcc-055824	Macaca mulatta	96.89	0.00e+00	634.00
IUUC-Mmr-061281	Microcebus murinus	77.41	2.00e-168	585.00
IUUC-Mdo-062515	Monodelphis domestica	70.47	2.00e-153	535.00
IUUC-Mmu-064341	Mus musculus	81.21	0.00e+00	672.00
IUUC-Mpu-066565	Mustela putorius furo	83.33	0.00e+00	678.00
IUUC-Mlu-066942	Myotis lucifugus	80.59	0.00e+00	664.00
IUUC-Nle-069436	Nomascus leucogenys	93.81	0.00e+00	738.00
IUUC-Opr-070288	Ochotona princeps	76.64	1.00e-165	575.00
IUUC-Ocu-074686	Oryctolagus cuniculus	83.94	2.00e-179	622.00
IUUC-Ola-086894	Oryzias latipes	59.44	2.00e-94	339.00
IUUC-Oga-088585	Otolemur garnettii	75.86	0.00e+00	648.00
IUUC-Oar-089686	Ovis aries	86.01	0.00e+00	702.00
IUUC-Ptr-090461	Pan troglodytes	94.03	0.00e+00	740.00
IUUC-Pan-091887	Papio anubis	97.18	0.00e+00	637.00
IUUC-Psi-093785	Pelodiscus sinensis	51.91	2.00e-138	486.00
IUUC-Pab-098222	Pongo abelii	97.46	0.00e+00	637.00
IUUC-Pca-100668	Procavia capensis	80.99	0.00e+00	661.00
IUUC-Pva-102767	Pteropus vampyrus	73.05	2.00e-165	575.00
IUUC-Rno-106001	Rattus norvegicus	83.44	0.00e+00	676.00
IUUC-Sar-113338	Sorex araneus	75.32	3.00e-168	585.00
IUUC-Ssc-116027	Sus scrofa	84.94	0.00e+00	719.00
IUUC-Tgu-117472	Taeniopygia guttata	58.74	2.00e-152	532.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence