iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000181191.11	ENST00000471141.1	ENSP00000467564.1
ENSG00000181191.11	ENST00000374583.1	ENSP00000363711.1
ENSG00000181191.11	ENST00000374584.3	ENSP00000363712.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM	SZDB
DNA & RNA Element
UTRdb	CircNet	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB
Disease-associated Information
GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	11959851; 12036302; 18786927

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	8.80e-06	27.8	595	636

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdg..plvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC++++ +g     lpC H fh+ C+  w       +k+ +CP+Cr
   Q: 595  CPICCSEYVKGevATELPCHHYFHKPCVSIW------LQKSGTCPVCR 636
           ********4443233499*************......**********8 PP

Organism

Homo sapiens

Functional Description
(View)

Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting.

Protein Sequence
(Fasta)

MGQESSKPVW PNPTGGYQSN TGRRYGRRHA YVSFRPPTSQ RERIASQRKT NSEVPMHRSA 60
PSQTTKRSRS PFSTTRRSWD DSESSGTNLN IDNEDYSRYP PREYRASGSR RGMAYGHIDS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGATGTGAT GTAGTAACGT AATTACTCTC ACATTGGACT TAATCAGAAA GAATTTGCAG 60
ATTTTATTTT ATTTATTAAA AAACCAGAAG GCAATATAGC TAAATGTTTA ACATTAGTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR031227--PJA1
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0030163--P:protein catabolic process

KEGG

hsa:64219

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002058	Ailuropoda melanoleuca	85.14	0.00e+00	935.00
IUUC-Apl-003808	Anas platyrhynchos	67.21	9.00e-59	219.00
IUUC-Bdi-014634	Brachypodium distachyon	33.08	2.00e-14	72.40
IUUC-Cja-019832	Callithrix jacchus	90.75	6.00e-119	421.00
IUUC-Cfa-020124	Canis familiaris	83.84	6.00e-150	523.00
IUUC-Csa-023998	Chlorocebus sabaeus	95.81	0.00e+00	1051.00
IUUC-Cho-024393	Choloepus hoffmanni	76.29	1.00e-142	499.00
IUUC-Dno-029806	Dasypus novemcinctus	82.24	0.00e+00	763.00
IUUC-Ete-032338	Echinops telfairi	77.76	0.00e+00	681.00
IUUC-Eca-034421	Equus caballus	84.81	7.00e-145	506.00
IUUC-Fca-035465	Felis catus	84.01	0.00e+00	924.00
IUUC-Gma-042873	Glycine max	35.48	6.00e-18	84.00
IUUC-Ggo-044735	Gorilla gorilla	99.53	0.00e+00	1098.00
IUUC-Itr-048973	Ictidomys tridecemlineatus	85.67	0.00e+00	1001.00
IUUC-Laf-054182	Loxodonta africana	78.05	0.00e+00	712.00
IUUC-Mcc-055292	Macaca mulatta	96.94	0.00e+00	940.00
IUUC-Mga-059909	Meleagris gallopavo	68.37	2.00e-23	100.00
IUUC-Mmr-061024	Microcebus murinus	88.99	0.00e+00	952.00
IUUC-Mmu-063776	Mus musculus	73.56	0.00e+00	707.00
IUUC-Mpu-066644	Mustela putorius furo	85.58	0.00e+00	981.00
IUUC-Mlu-067639	Myotis lucifugus	78.14	0.00e+00	885.00
IUUC-Ocu-073783	Oryctolagus cuniculus	81.39	1.00e-146	512.00
IUUC-Oga-088286	Otolemur garnettii	87.29	0.00e+00	986.00
IUUC-Oar-089497	Ovis aries	83.72	0.00e+00	924.00
IUUC-Pan-092534	Papio anubis	94.06	0.00e+00	931.00
IUUC-Pca-100336	Procavia capensis	72.22	4.00e-157	548.00
IUUC-Rno-105580	Rattus norvegicus	78.21	3.00e-115	408.00
IUUC-Ssc-116194	Sus scrofa	85.27	0.00e+00	957.00
IUUC-Tsy-118954	Tarsius syrichta	74.53	3.00e-136	479.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence