iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pab-098168

Ensembl Protein ID

ENSPPYP00000001840.2

UniProt Accession

H2N854; H2N854_PONAB

Genbank Protein ID

ENSPPYP00000001840

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

ABGA01402751

Gene Name

LCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000001596.2	ENSPPYT00000001899.2	ENSPPYP00000001840.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	9.30e-19	67.2	40	98

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++++v++l++ye+++d++L ++kG++++++   e++++W+k+++ ++g++G++P nFv+k++
   Q: 40   QDNLVIALHSYEPSHDGDLGFEKGEQLRIL---EESGEWWKAQSLTTGQEGFIPFNFVAKAN 98
           6899**************************...99************************987 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

CHYPIVPLDG KGKLPIRNGS EVRDPLVTYE GCNPPASPLQ DNLVIALHSY EPSHDGDLGF 60
EKGEQLRILE ESGEWWKAQS LTTGQEGFIP FNFVAKANSL EPEPWFFKNL SRKDAERQLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCCATTATC CCATAGTCCC ACTGGATGGC AAGGGCAAGG TAAGAGCCGT GACAGGGGCC 60
TTGGTAAGGG AGTTGGGTAG AGCATGCACC CCAGGAGAAA GAAATGACCA GCACTACAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0001772--C:immunological synapse
GO:0045121--C:membrane raft
GO:0000242--C:pericentriolar material
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004722--F:protein serine/threonine phosphatase activity
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006882--P:cellular zinc ion homeostasis
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0050870--P:positive regulation of T cell activation
GO:0042493--P:response to drug
GO:0030217--P:T cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001315	Ailuropoda melanoleuca	92.07	0.00e+00	974.00
IUUC-Apl-004134	Anas platyrhynchos	81.01	0.00e+00	736.00
IUUC-Bta-013264	Bos taurus	95.69	0.00e+00	973.00
IUUC-Cja-019574	Callithrix jacchus	94.54	0.00e+00	706.00
IUUC-Cfa-021161	Canis familiaris	91.30	0.00e+00	968.00
IUUC-Cpo-022492	Cavia porcellus	95.48	0.00e+00	962.00
IUUC-Csa-023270	Chlorocebus sabaeus	78.43	0.00e+00	760.00
IUUC-Dre-028005	Danio rerio	75.22	0.00e+00	726.00
IUUC-Dno-029365	Dasypus novemcinctus	93.84	0.00e+00	938.00
IUUC-Dor-030892	Dipodomys ordii	91.43	0.00e+00	944.00
IUUC-Eca-033325	Equus caballus	94.88	0.00e+00	951.00
IUUC-Eeu-035004	Erinaceus europaeus	88.31	0.00e+00	759.00
IUUC-Fca-035908	Felis catus	97.33	0.00e+00	988.00
IUUC-Fal-036804	Ficedula albicollis	70.89	0.00e+00	694.00
IUUC-Gmo-038984	Gadus morhua	67.16	0.00e+00	681.00
IUUC-Gga-040997	Gallus gallus	83.78	0.00e+00	868.00
IUUC-Gac-041854	Gasterosteus aculeatus	73.51	0.00e+00	710.00
IUUC-Gma-043628	Glycine max	31.84	2.00e-20	94.40
IUUC-Ggo-045238	Gorilla gorilla	93.04	0.00e+00	983.00
IUUC-Hsa-047039	Homo sapiens	98.77	0.00e+00	999.00
IUUC-Hvu-047815	Hordeum vulgare	28.86	6.00e-20	92.80
IUUC-Itr-048479	Ictidomys tridecemlineatus	97.33	0.00e+00	983.00
IUUC-Lch-049568	Latimeria chalumnae	78.57	0.00e+00	815.00
IUUC-Laf-054499	Loxodonta africana	90.91	0.00e+00	963.00
IUUC-Mcc-054872	Macaca mulatta	77.06	0.00e+00	809.00
IUUC-Meu-056879	Macropus eugenii	91.85	0.00e+00	939.00
IUUC-Mtr-058765	Medicago truncatula	34.15	5.00e-20	93.20
IUUC-Mga-059971	Meleagris gallopavo	84.39	0.00e+00	875.00
IUUC-Mmr-060740	Microcebus murinus	96.92	0.00e+00	985.00
IUUC-Mdo-062192	Monodelphis domestica	93.43	0.00e+00	956.00
IUUC-Mmu-064241	Mus musculus	96.51	0.00e+00	980.00
IUUC-Mpu-066595	Mustela putorius furo	97.33	0.00e+00	985.00
IUUC-Mlu-067069	Myotis lucifugus	95.29	0.00e+00	966.00
IUUC-Opr-070472	Ochotona princeps	91.60	0.00e+00	961.00
IUUC-Ont-071711	Oreochromis niloticus	70.40	0.00e+00	677.00
IUUC-Ocu-074221	Oryctolagus cuniculus	96.31	0.00e+00	976.00
IUUC-Ola-087000	Oryzias latipes	69.90	0.00e+00	707.00
IUUC-Oga-088225	Otolemur garnettii	96.30	0.00e+00	976.00
IUUC-Oar-090244	Ovis aries	84.17	0.00e+00	912.00
IUUC-Ptr-090751	Pan troglodytes	99.14	0.00e+00	725.00
IUUC-Pan-091804	Papio anubis	98.36	0.00e+00	996.00
IUUC-Psi-093252	Pelodiscus sinensis	75.61	0.00e+00	761.00
IUUC-Pfo-096542	Poecilia formosa	72.17	0.00e+00	706.00
IUUC-Pca-100547	Procavia capensis	96.32	4.00e-172	597.00
IUUC-Rno-105542	Rattus norvegicus	96.10	0.00e+00	977.00
IUUC-Sha-107524	Sarcophilus harrisii	92.20	0.00e+00	948.00
IUUC-Sar-113235	Sorex araneus	88.64	0.00e+00	810.00
IUUC-Ssc-115624	Sus scrofa	95.89	0.00e+00	974.00
IUUC-Tru-118559	Takifugu rubripes	73.48	0.00e+00	707.00
IUUC-Tca-121341	Theobroma cacao	32.70	6.00e-22	99.40
IUUC-Ttr-129002	Tursiops truncatus	86.46	0.00e+00	902.00
IUUC-Xtr-132224	Xenopus tropicalis	75.77	0.00e+00	790.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence