iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xtr-132224

Ensembl Protein ID

ENSXETP00000011470.2

UniProt Accession

F6ULV4; F6ULV4_XENTR

Genbank Protein ID

ENSXETP00000011470

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AAMC01090999

Gene Name

lck

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000005250.2	ENSXETT00000011470.2	ENSXETP00000011470.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	9.60e-16	57.7	63	120

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++v +ly+ye+ +d++L +++G++++v+   eq  +W+k+++  +g+ G +P nFv+ ++
   Q: 63   DNLVVALYNYEPMHDEDLGFEAGEKLHVL---EQKDEWWKAKSLRTGQVGYIPYNFVASVN 120
           689**************************...9999*********************9986 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MGCGCSSEYE DDWIENFDVC DHCHLPRQKL TKMAAILLIT CYDIQDPLVS YTGLNPPSSP 60
LHDNLVVALY NYEPMHDEDL GFEAGEKLHV LEQKDEWWKA KSLRTGQVGY IPYNFVASVN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGATGTG GGTGCAGCTC TGAGTATGAA GATGACTGGA TTGAAAATTT TGATGTGTGT 60
GATCACTGCC ATCTTCCTAG ACAGAAGTCT GAGGTTAGTA CTGTAAATAC CAATAGGCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0050853--P:B cell receptor signaling pathway
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0030217--P:T cell differentiation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000140	Aegilops tauschii	30.08	1.00e-21	99.00
IUUC-Aml-001315	Ailuropoda melanoleuca	71.99	0.00e+00	818.00
IUUC-Apl-004134	Anas platyrhynchos	75.00	0.00e+00	686.00
IUUC-Ame-011954	Astyanax mexicanus	66.88	0.00e+00	657.00
IUUC-Bta-013264	Bos taurus	76.03	0.00e+00	831.00
IUUC-Bdi-014122	Brachypodium distachyon	32.16	2.00e-21	98.20
IUUC-Cja-019817	Callithrix jacchus	71.59	0.00e+00	692.00
IUUC-Cfa-021161	Canis familiaris	71.61	0.00e+00	813.00
IUUC-Cpo-022492	Cavia porcellus	75.83	0.00e+00	835.00
IUUC-Csa-024143	Chlorocebus sabaeus	72.04	0.00e+00	695.00
IUUC-Dre-028005	Danio rerio	73.21	0.00e+00	695.00
IUUC-Dno-029365	Dasypus novemcinctus	72.50	0.00e+00	785.00
IUUC-Dor-030892	Dipodomys ordii	74.34	0.00e+00	781.00
IUUC-Eca-033325	Equus caballus	74.12	0.00e+00	800.00
IUUC-Eeu-035004	Erinaceus europaeus	67.57	0.00e+00	629.00
IUUC-Fca-035908	Felis catus	76.03	0.00e+00	832.00
IUUC-Fal-036624	Ficedula albicollis	68.61	0.00e+00	678.00
IUUC-Gmo-038984	Gadus morhua	64.91	0.00e+00	694.00
IUUC-Gga-040997	Gallus gallus	76.42	0.00e+00	840.00
IUUC-Gac-041854	Gasterosteus aculeatus	68.43	0.00e+00	715.00
IUUC-Ggo-045238	Gorilla gorilla	71.80	0.00e+00	819.00
IUUC-Hsa-047039	Homo sapiens	76.03	0.00e+00	835.00
IUUC-Hvu-047855	Hordeum vulgare	30.86	4.00e-22	99.80
IUUC-Itr-048479	Ictidomys tridecemlineatus	76.23	0.00e+00	839.00
IUUC-Lch-049568	Latimeria chalumnae	75.78	0.00e+00	826.00
IUUC-Loc-052904	Lepisosteus oculatus	69.43	0.00e+00	692.00
IUUC-Laf-054499	Loxodonta africana	71.80	0.00e+00	815.00
IUUC-Mcc-055317	Macaca mulatta	71.81	0.00e+00	697.00
IUUC-Meu-056879	Macropus eugenii	74.85	0.00e+00	822.00
IUUC-Mga-059971	Meleagris gallopavo	75.44	0.00e+00	818.00
IUUC-Mmr-060740	Microcebus murinus	75.64	0.00e+00	832.00
IUUC-Mdo-062192	Monodelphis domestica	76.23	0.00e+00	835.00
IUUC-Mmu-064241	Mus musculus	74.85	0.00e+00	825.00
IUUC-Mpu-066595	Mustela putorius furo	75.44	0.00e+00	828.00
IUUC-Mlu-067069	Myotis lucifugus	75.49	0.00e+00	823.00
IUUC-Nle-069222	Nomascus leucogenys	71.14	0.00e+00	694.00
IUUC-Opr-070472	Ochotona princeps	71.91	0.00e+00	809.00
IUUC-Ont-071711	Oreochromis niloticus	69.80	0.00e+00	712.00
IUUC-Ocu-074221	Oryctolagus cuniculus	74.90	0.00e+00	816.00
IUUC-Ola-087000	Oryzias latipes	67.13	0.00e+00	705.00
IUUC-Oga-088225	Otolemur garnettii	75.25	0.00e+00	826.00
IUUC-Oar-090244	Ovis aries	67.08	0.00e+00	775.00
IUUC-Pan-091804	Papio anubis	76.23	0.00e+00	838.00
IUUC-Psi-093252	Pelodiscus sinensis	68.68	0.00e+00	723.00
IUUC-Pma-094311	Petromyzon marinus	63.33	0.00e+00	664.00
IUUC-Pfo-096542	Poecilia formosa	67.70	0.00e+00	724.00
IUUC-Pab-098168	Pongo abelii	75.77	0.00e+00	790.00
IUUC-Pva-103021	Pteropus vampyrus	69.43	0.00e+00	682.00
IUUC-Rno-105542	Rattus norvegicus	74.85	0.00e+00	827.00
IUUC-Sha-107524	Sarcophilus harrisii	76.62	0.00e+00	838.00
IUUC-Sar-113235	Sorex araneus	70.49	0.00e+00	694.00
IUUC-Ssc-115624	Sus scrofa	75.83	0.00e+00	828.00
IUUC-Tgu-116912	Taeniopygia guttata	70.16	0.00e+00	675.00
IUUC-Tru-118559	Takifugu rubripes	68.10	0.00e+00	707.00
IUUC-Tae-123192	Triticum aestivum	30.47	3.00e-22	100.00
IUUC-Tur-126022	Triticum urartu	30.47	6.00e-22	99.80
IUUC-Ttr-129002	Tursiops truncatus	69.20	0.00e+00	769.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence