iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA
DNA & RNA Element
UTRdb	microRNA	TRANSFAC	TargetScan
RepTar	miRcode	RAID2
Protein-protein Interaction
IID
Disease-associated Variation
GWASdb
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	3.20e-06	29.2	16	56

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlC 45
           C+iCl+ +kd p++ +CgH f+++C+   w    +    +f CP C
   Q: 16   CPICLDYLKD-PVTISCGHNFCLSCIiMSW----KDLHDSFPCPFC 56
           **********.999***********99999....778899****** PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MEFVTALADL RAEASCPICL DYLKDPVTIS CGHNFCLSCI IMSWKDLHDS FPCPFCHFCC 60
PERKFISNPQ LGSLTEIAKQ LQIRSKKRKR QEEKHVCKKH NQVLTFFCQK DLELLCPRCS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACTGCCAAC CACCGCGCAG GCTGAGCCCC AGGCAGGAAG CAGCCCACTT GGTGGGGTTG 60
GGGTATGAGT CCTTCCTCGC GGGGGCTCGG TGGGTCCTGA GTATTCTTTG GCCGGATTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00643--zf-B_box

SMART

SM00184--RING

Gene Ontology

GO:0005622--C:intracellular
GO:0008270--F:zinc ion binding

KEGG

hsa:391712

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cja-019867	Callithrix jacchus	79.49	1.00e-86	312.00
IUUC-Csa-023218	Chlorocebus sabaeus	94.35	5.00e-87	313.00
IUUC-Mcc-055880	Macaca mulatta	94.97	6.00e-100	356.00
IUUC-Nle-068984	Nomascus leucogenys	97.49	9.00e-101	358.00
IUUC-Ptr-090874	Pan troglodytes	98.86	2.00e-80	291.00
IUUC-Pab-097574	Pongo abelii	98.31	1.00e-91	328.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence