iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	1.40e-19	71.9	46	114
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	5.70e-09	35.2	146	177

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd.vqpevfrallkFlYtgkldene 69
           +Dv+l  g++ f++h++vLaasS++F+a+f+++l+es+  ++v+++d + pev++ ll+F Y++++ +ne
   Q: 46   TDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESR-DDTVNFQDnLHPEVLELLLDFAYSSRIAINE 114
           7*************************************.*******99*****************99987 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           ++Nclg++ ++d+++c++L+++  +++l hF+
   Q: 146  PSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFE 177
           89*****************************5 PP

Organism

Homo sapiens

Functional Description
(View)

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.

Protein Sequence
(Fasta)

MSVSVHETRK SRSSTGSMNV TLFHKASHPD CVLAHLNTLR KHCMFTDVTL WAGDRAFPCH 60
RAVLAASSRY FEAMFSHGLR ESRDDTVNFQ DNLHPEVLEL LLDFAYSSRI AINEENAESL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTTCTGCG GCTGCACTGA AGGGTTCGGC TGCCCATCCG TCACAGAGGC GATGCCTCTG 60
ATTGGCTGCT GCTCTTCGGG CCGGGAGGCG GGGCGGGAAG GCCGGAGAAA CTAGTTTGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0810--Translation regulation
KW-0833--Ubl conjugation pathway

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030565--KLHL25
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006446--P:regulation of translational initiation

KEGG

hsa:64410

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002373	Ailuropoda melanoleuca	97.62	0.00e+00	1211.00
IUUC-Apl-003543	Anas platyrhynchos	90.34	0.00e+00	1099.00
IUUC-Aca-004729	Anolis carolinensis	87.61	0.00e+00	1079.00
IUUC-Ame-011020	Astyanax mexicanus	85.23	0.00e+00	1036.00
IUUC-Bta-012955	Bos taurus	95.59	0.00e+00	1191.00
IUUC-Cja-018839	Callithrix jacchus	98.98	0.00e+00	1221.00
IUUC-Cfa-020224	Canis familiaris	97.79	0.00e+00	1208.00
IUUC-Cpo-021593	Cavia porcellus	93.55	0.00e+00	1121.00
IUUC-Csa-023276	Chlorocebus sabaeus	99.66	0.00e+00	1229.00
IUUC-Dre-028053	Danio rerio	85.40	0.00e+00	1013.00
IUUC-Dno-029287	Dasypus novemcinctus	94.91	0.00e+00	1180.00
IUUC-Dor-030908	Dipodomys ordii	88.79	0.00e+00	1077.00
IUUC-Fca-035897	Felis catus	97.96	0.00e+00	1212.00
IUUC-Fal-037036	Ficedula albicollis	90.32	0.00e+00	1104.00
IUUC-Gmo-039345	Gadus morhua	85.23	0.00e+00	1006.00
IUUC-Gga-040404	Gallus gallus	90.15	0.00e+00	1105.00
IUUC-Gac-042447	Gasterosteus aculeatus	84.72	0.00e+00	1020.00
IUUC-Ggo-045060	Gorilla gorilla	99.83	0.00e+00	1231.00
IUUC-Itr-047993	Ictidomys tridecemlineatus	97.96	0.00e+00	1208.00
IUUC-Lch-050211	Latimeria chalumnae	86.56	0.00e+00	1053.00
IUUC-Loc-052578	Lepisosteus oculatus	85.06	0.00e+00	1042.00
IUUC-Lma-053168	Leptosphaeria maculans	29.79	1.00e-04	41.20
IUUC-Laf-053498	Loxodonta africana	95.93	0.00e+00	1141.00
IUUC-Mcc-055033	Macaca mulatta	99.49	0.00e+00	1228.00
IUUC-Meu-056893	Macropus eugenii	93.38	0.00e+00	1160.00
IUUC-Mga-060025	Meleagris gallopavo	90.32	0.00e+00	1104.00
IUUC-Mmr-060658	Microcebus murinus	97.79	0.00e+00	1212.00
IUUC-Mdo-062667	Monodelphis domestica	93.21	0.00e+00	1155.00
IUUC-Mmu-063125	Mus musculus	94.91	0.00e+00	1145.00
IUUC-Mpu-066209	Mustela putorius furo	97.79	0.00e+00	1212.00
IUUC-Mlu-068237	Myotis lucifugus	93.89	0.00e+00	1142.00
IUUC-Nle-069454	Nomascus leucogenys	99.83	0.00e+00	1217.00
IUUC-Ont-072138	Oreochromis niloticus	84.89	0.00e+00	1009.00
IUUC-Oan-073320	Ornithorhynchus anatinus	86.08	0.00e+00	1074.00
IUUC-Ocu-073765	Oryctolagus cuniculus	90.15	0.00e+00	1100.00
IUUC-Oga-088002	Otolemur garnettii	97.79	0.00e+00	1201.00
IUUC-Oar-089481	Ovis aries	95.08	0.00e+00	1186.00
IUUC-Ptr-091200	Pan troglodytes	99.83	0.00e+00	1228.00
IUUC-Psi-093884	Pelodiscus sinensis	89.98	0.00e+00	1092.00
IUUC-Pno-095143	Phaeosphaeria nodorum	27.24	4.00e-15	75.90
IUUC-Pab-098588	Pongo abelii	88.96	0.00e+00	1064.00
IUUC-Pva-102321	Pteropus vampyrus	96.77	0.00e+00	1199.00
IUUC-Rno-104835	Rattus norvegicus	94.74	0.00e+00	1144.00
IUUC-Sha-107528	Sarcophilus harrisii	93.21	0.00e+00	1159.00
IUUC-Ssc-116161	Sus scrofa	97.79	0.00e+00	1208.00
IUUC-Tgu-116569	Taeniopygia guttata	90.15	0.00e+00	1100.00
IUUC-Tni-120525	Tetraodon nigroviridis	75.80	0.00e+00	882.00
IUUC-Ttr-129297	Tursiops truncatus	96.77	0.00e+00	1198.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence