iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-005063

UUCD1 version

UUC-AnC-00849

Ensembl Protein ID

ENSACAP00000016418.2

UniProt Accession

G1KSY2; G1KSY2_ANOCA

Protein Name

Uncharacterized protein

Gene Name

SOCS3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000016701.3	ENSACAT00000016743.3	ENSACAP00000016418.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	82.38	5.00e-102	367.00	IUUC-Hsa-046909

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MVTHRKFPSA AGMSHPLDTS LRLKTFSSKS EYQLVVNAVR KLQESGFYWS AVTGGQANLL 60
LSAEPTGTFL IRDSSDQRHF FTLSVKTESG TKNLRIQCEG GSFSLQSDPH SSQPVPRFDC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGAAACTG CCAGCCAGGC TTGCTCTGGG CGCTGGAAAT CGTGCCACAG CCATGACTTG 60
GCAAGCCTTC GCTTTGGCTA GCGCACAGGG TCGGCAGCAG GGCGGGAAGC GCGCCCCCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028414--SOCS3
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0007259--P:JAK-STAT cascade
GO:0043066--P:negative regulation of apoptotic process
GO:0050728--P:negative regulation of inflammatory response
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0045597--P:positive regulation of cell differentiation
GO:0016567--P:protein ubiquitination

KEGG

acs:100564374

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001529	Ailuropoda melanoleuca	78.76	9.00e-98	348.00
IUUC-Apl-003607	Anas platyrhynchos	86.73	2.00e-93	334.00
IUUC-Ath-006990	Arabidopsis thaliana	33.78	3.20e-02	33.90
IUUC-Ame-010859	Astyanax mexicanus	57.33	2.00e-66	244.00
IUUC-Bta-012817	Bos taurus	80.00	7.00e-100	356.00
IUUC-Bdi-014242	Brachypodium distachyon	34.48	6.50e-01	27.70
IUUC-Bra-017963	Brassica rapa	29.33	9.60e-02	31.60
IUUC-Cja-019605	Callithrix jacchus	80.09	4.00e-100	356.00
IUUC-Cfa-021231	Canis familiaris	80.09	2.00e-99	354.00
IUUC-Cpo-022003	Cavia porcellus	79.91	5.00e-99	353.00
IUUC-Csa-023511	Chlorocebus sabaeus	81.14	3.00e-100	357.00
IUUC-Dre-028536	Danio rerio	61.57	7.00e-71	259.00
IUUC-Dno-029003	Dasypus novemcinctus	80.62	2.00e-99	354.00
IUUC-Eca-034205	Equus caballus	69.83	9.00e-63	232.00
IUUC-Fca-036317	Felis catus	81.82	4.00e-97	346.00
IUUC-Gmo-038777	Gadus morhua	63.89	4.00e-36	142.00
IUUC-Gga-041258	Gallus gallus	87.20	3.00e-94	337.00
IUUC-Gac-041837	Gasterosteus aculeatus	61.05	9.00e-65	239.00
IUUC-Ggo-045620	Gorilla gorilla	81.14	3.00e-100	357.00
IUUC-Hsa-046909	Homo sapiens	81.14	3.00e-100	357.00
IUUC-Itr-048023	Ictidomys tridecemlineatus	78.90	8.00e-101	359.00
IUUC-Lch-049510	Latimeria chalumnae	70.09	5.00e-81	293.00
IUUC-Loc-052863	Lepisosteus oculatus	65.28	2.00e-76	278.00
IUUC-Laf-054136	Loxodonta africana	79.91	6.00e-100	356.00
IUUC-Mcc-055383	Macaca mulatta	81.14	3.00e-100	357.00
IUUC-Meu-056153	Macropus eugenii	78.21	5.00e-99	353.00
IUUC-Mmr-061185	Microcebus murinus	79.74	9.00e-99	352.00
IUUC-Mdo-061819	Monodelphis domestica	79.39	1.00e-99	355.00
IUUC-Mmu-064231	Mus musculus	82.02	9.00e-104	369.00
IUUC-Mpu-066691	Mustela putorius furo	80.09	2.00e-99	354.00
IUUC-Mlu-067673	Myotis lucifugus	79.91	2.00e-102	364.00
IUUC-Ont-072406	Oreochromis niloticus	58.60	6.00e-67	246.00
IUUC-Oan-073249	Ornithorhynchus anatinus	78.20	8.00e-90	322.00
IUUC-Ocu-074935	Oryctolagus cuniculus	79.10	3.00e-28	115.00
IUUC-Ola-087373	Oryzias latipes	49.74	6.00e-48	183.00
IUUC-Oga-088041	Otolemur garnettii	81.78	2.00e-100	357.00
IUUC-Oar-089646	Ovis aries	76.52	8.00e-95	339.00
IUUC-Ptr-091502	Pan troglodytes	81.14	3.00e-100	357.00
IUUC-Pan-091934	Papio anubis	81.14	3.00e-100	357.00
IUUC-Pfo-096412	Poecilia formosa	44.76	4.00e-48	183.00
IUUC-Pab-098554	Pongo abelii	81.14	3.00e-100	357.00
IUUC-Rno-105874	Rattus norvegicus	81.14	2.00e-102	364.00
IUUC-Sha-107151	Sarcophilus harrisii	77.54	1.00e-98	352.00
IUUC-Ssc-115722	Sus scrofa	71.35	8.00e-61	225.00
IUUC-Tgu-117151	Taeniopygia guttata	87.68	4.00e-95	340.00
IUUC-Tru-118428	Takifugu rubripes	57.67	5.00e-66	243.00
IUUC-Tni-120590	Tetraodon nigroviridis	58.14	5.00e-66	243.00
IUUC-Ttr-129065	Tursiops truncatus	79.31	8.00e-100	355.00
IUUC-Xtr-132167	Xenopus tropicalis	70.95	5.00e-82	296.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence