iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	miRWalk	TargetScan
miRecords	RepTar	miRcode	RAID2
LncRNADisease
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
OMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	SOCS	16616006; 12228220; 25939384

Organism

Homo sapiens

Functional Description
(View)

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).

Protein Sequence
(Fasta)

MVTHSKFPAA GMSRPLDTSL RLKTFSSKSE YQLVVNAVRK LQESGFYWSA VTGGEANLLL 60
SAEPAGTFLI RDSSDQRHFF TLSVKTQSGT KNLRIQCEGG SFSLQSDPRS TQPVPRFDCV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCTCCGACT TGGACTCCCT GCTCCGCTGC TGCCGCTTCG GCCCCGCACG CAGCCAGCCG 60
CCAGCCGCCC GCCCGGCCCA GCTCCCGCCG CGGCCCCTTG CCGCGGTCCC TCTCCTGGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0341--Growth regulation
KW-0582--Pharmaceutical
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0734--Signal transduction inhibitor
KW-0833--Ubl conjugation pathway

Interpro

IPR000980--SH2
IPR028414--SOCS3
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0004860--F:protein kinase inhibitor activity
GO:0060670--P:branching involved in labyrinthine layer morphogenesis
GO:0019221--P:cytokine-mediated signaling pathway
GO:0007259--P:JAK-STAT cascade
GO:0043066--P:negative regulation of apoptotic process
GO:0050728--P:negative regulation of inflammatory response
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0060674--P:placenta blood vessel development
GO:0045597--P:positive regulation of cell differentiation
GO:0042517--P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0016567--P:protein ubiquitination
GO:0040008--P:regulation of growth
GO:0060334--P:regulation of interferon-gamma-mediated signaling pathway
GO:0060708--P:spongiotrophoblast differentiation
GO:0060707--P:trophoblast giant cell differentiation

KEGG

hsa:9021

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001529	Ailuropoda melanoleuca	96.44	1.00e-107	382.00
IUUC-Apl-003607	Anas platyrhynchos	82.22	9.00e-97	345.00
IUUC-Aca-005063	Anolis carolinensis	82.38	2.00e-103	367.00
IUUC-Ath-006990	Arabidopsis thaliana	32.94	9.00e-03	36.20
IUUC-Ame-010859	Astyanax mexicanus	57.39	5.00e-71	260.00
IUUC-Bta-012817	Bos taurus	91.70	2.00e-111	394.00
IUUC-Bra-017963	Brassica rapa	30.00	6.20e-02	32.30
IUUC-Cja-019605	Callithrix jacchus	99.11	2.00e-114	404.00
IUUC-Cfa-021231	Canis familiaris	97.78	4.00e-109	387.00
IUUC-Cpo-022003	Cavia porcellus	91.23	2.00e-107	381.00
IUUC-Csa-023511	Chlorocebus sabaeus	100.00	7.00e-113	399.00
IUUC-Dre-028536	Danio rerio	59.57	1.00e-73	269.00
IUUC-Dno-029003	Dasypus novemcinctus	92.44	5.00e-110	390.00
IUUC-Eca-034205	Equus caballus	83.80	4.00e-68	250.00
IUUC-Fca-036317	Felis catus	95.96	2.00e-108	384.00
IUUC-Gmo-038777	Gadus morhua	63.89	9.00e-36	142.00
IUUC-Gga-041258	Gallus gallus	83.11	7.00e-97	346.00
IUUC-Gac-041837	Gasterosteus aculeatus	55.90	2.00e-65	241.00
IUUC-Ggo-045620	Gorilla gorilla	100.00	7.00e-113	399.00
IUUC-Itr-048023	Ictidomys tridecemlineatus	91.91	7.00e-112	396.00
IUUC-Lch-049510	Latimeria chalumnae	68.12	8.00e-85	306.00
IUUC-Loc-052863	Lepisosteus oculatus	63.04	1.00e-79	288.00
IUUC-Laf-054136	Loxodonta africana	92.54	2.00e-109	387.00
IUUC-Mcc-055383	Macaca mulatta	100.00	7.00e-113	399.00
IUUC-Meu-056153	Macropus eugenii	88.50	2.00e-110	391.00
IUUC-Mmr-061185	Microcebus murinus	95.13	3.00e-107	380.00
IUUC-Mdo-061819	Monodelphis domestica	89.33	1.00e-113	402.00
IUUC-Mmu-064231	Mus musculus	96.89	2.00e-119	421.00
IUUC-Mpu-066691	Mustela putorius furo	98.67	4.00e-109	387.00
IUUC-Mlu-067673	Myotis lucifugus	96.02	3.00e-116	410.00
IUUC-Ont-072406	Oreochromis niloticus	55.02	2.00e-68	251.00
IUUC-Oan-073249	Ornithorhynchus anatinus	74.67	7.00e-94	336.00
IUUC-Ocu-074935	Oryctolagus cuniculus	88.41	6.00e-32	128.00
IUUC-Ola-087373	Oryzias latipes	48.04	3.00e-48	184.00
IUUC-Oga-088041	Otolemur garnettii	92.89	1.00e-109	388.00
IUUC-Oar-089646	Ovis aries	90.39	2.00e-103	368.00
IUUC-Ptr-091502	Pan troglodytes	100.00	7.00e-113	399.00
IUUC-Pan-091934	Papio anubis	100.00	7.00e-113	399.00
IUUC-Pfo-096412	Poecilia formosa	42.79	3.00e-48	184.00
IUUC-Pab-098554	Pongo abelii	100.00	7.00e-113	399.00
IUUC-Rno-105874	Rattus norvegicus	96.44	4.00e-119	420.00
IUUC-Sha-107151	Sarcophilus harrisii	87.28	3.00e-110	390.00
IUUC-Ssc-115722	Sus scrofa	88.37	2.00e-65	240.00
IUUC-Tgu-117151	Taeniopygia guttata	84.00	4.00e-97	347.00
IUUC-Tru-118428	Takifugu rubripes	54.15	2.00e-68	251.00
IUUC-Tni-120590	Tetraodon nigroviridis	54.59	4.00e-67	247.00
IUUC-Ttr-129065	Tursiops truncatus	93.01	4.00e-111	393.00
IUUC-Xtr-132167	Xenopus tropicalis	65.78	1.00e-81	295.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence