iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	20935222; 19615732; 11788588

Classification

Family	E-value	Score	Start	End
DUB/USP	6.20e-58	198.3	55	370

Active Site

Position(s)	Description	Evidence
64	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
318	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDa 92
           +Gl+N+g tC +NS++Q+ ++  ++++ l++    ++++ + +e+  ++  ++  l+e++++s++kav p el  +l+k+++    + q+Da
   Q: 55   VGLHNIGQTCCLNSLIQVFVMNVDFTRILKR---ITVPRGA-DEQRRSVPFQMLLLLEKMQDSRQKAVRPLELAYCLQKCNVP--LFVQHDA 140
           6******************************...5555443.567889*********************************99..79***** PP
   S: 93   qEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkk 184
             +   l + +++++                          ++ +  + ++ l+ +++k++++c +c+ +ssr++++l+l+l++ + +++ +
   Q: 141  AQLYLKLWNLIKDQI--------------------------TDVHLVERLQALYTIRVKDSLICVDCAMESSRNSSMLTLPLSLFDVDSKPL 206
           ***************..........................67788899***************************************999* PP
   S: 185  eslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls.......pfctspe 269
           ++l+d+L+ f+++ el ++ k++ce+c kk++ ++ lkl++lP++L++hL+Rfs ++  ++ +ki  +++fp++Ld s       + c    
   Q: 207  KTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRN--SQTRKICHSLYFPQSLDFSqilpmkrESCDA-- 294
           *****************************************************7755..6888***************554322112222.. PP
   S: 270  ekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetg.......staYvlfYkrr 338
            ++++  +YeL+av+ H G ++sGHY++y++n  +gkW++f+Ds++  v++e+++ + g       +taY+l+Y+++
   Q: 295  -EEQSGGQYELFAVIAHVGMADSGHYCVYIRNaVDGKWFCFNDSNICLVSWEDIQCTYGnpnyhwqETAYLLVYMKM 370
           .223389*************************55777*******************888***************986 PP

Organism

Homo sapiens

Functional Description
(View)

Isoform 2: Has enzymatic activity similar to isoform 1 and interferes with type I interferon signaling. Major deISGylation enzyme for nuclear proteins (PubMed:22170061).

Protein Sequence
(Fasta)

MSKAFGLLRQ ICQSILAESS QSPADLEEKK EEDSNMKREQ PRERPRAWDY PHGLVGLHNI 60
GQTCCLNSLI QVFVMNVDFT RILKRITVPR GADEQRRSVP FQMLLLLEKM QDSRQKAVRP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACAGAATGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAGCGAGG GCTGGAAGTC 60
TGGAGCAGGT GCGCGGCTGC AACGGCAGCC GCGGGAAGCT CGGGCCGGCA GGGTTTCCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0024--Alternative initiation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019785--F:ISG15-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0060338--P:regulation of type I interferon-mediated signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:11274

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001615	Ailuropoda melanoleuca	76.97	2.00e-159	555.00
IUUC-Apl-004006	Anas platyrhynchos	56.88	1.00e-105	375.00
IUUC-Aca-005088	Anolis carolinensis	55.38	7.00e-93	333.00
IUUC-Ame-010606	Astyanax mexicanus	32.28	5.00e-37	148.00
IUUC-Bta-013036	Bos taurus	76.18	1.00e-148	518.00
IUUC-Cja-019052	Callithrix jacchus	83.59	2.00e-158	551.00
IUUC-Cfa-020554	Canis familiaris	81.19	2.00e-165	575.00
IUUC-Cpo-022421	Cavia porcellus	72.27	9.00e-160	556.00
IUUC-Csa-023737	Chlorocebus sabaeus	93.60	7.00e-116	409.00
IUUC-Cho-024807	Choloepus hoffmanni	69.39	3.00e-70	258.00
IUUC-Dre-027408	Danio rerio	31.66	6.00e-43	167.00
IUUC-Dno-029813	Dasypus novemcinctus	66.31	9.00e-127	446.00
IUUC-Dor-030532	Dipodomys ordii	72.19	3.00e-159	554.00
IUUC-Ete-032254	Echinops telfairi	68.73	4.00e-154	537.00
IUUC-Eca-033482	Equus caballus	81.50	3.00e-159	554.00
IUUC-Eeu-034451	Erinaceus europaeus	72.51	6.00e-93	333.00
IUUC-Fca-036313	Felis catus	77.36	2.00e-165	575.00
IUUC-Fal-037216	Ficedula albicollis	52.94	6.00e-106	377.00
IUUC-Gmo-038649	Gadus morhua	32.70	3.00e-40	159.00
IUUC-Gga-041082	Gallus gallus	54.91	4.00e-95	341.00
IUUC-Gac-042439	Gasterosteus aculeatus	35.56	3.00e-50	192.00
IUUC-Itr-047918	Ictidomys tridecemlineatus	77.63	1.00e-171	595.00
IUUC-Loc-052688	Lepisosteus oculatus	34.47	2.00e-46	179.00
IUUC-Laf-054109	Loxodonta africana	77.75	6.00e-179	619.00
IUUC-Mcc-054814	Macaca mulatta	92.78	0.00e+00	727.00
IUUC-Meu-056253	Macropus eugenii	66.43	3.00e-107	381.00
IUUC-Mmr-061613	Microcebus murinus	81.19	4.00e-165	573.00
IUUC-Mdo-061890	Monodelphis domestica	63.39	1.00e-121	429.00
IUUC-Mmu-064329	Mus musculus	70.62	2.00e-147	514.00
IUUC-Mpu-066342	Mustela putorius furo	77.93	9.00e-169	586.00
IUUC-Mlu-067010	Myotis lucifugus	77.47	7.00e-169	586.00
IUUC-Nle-069148	Nomascus leucogenys	95.16	0.00e+00	741.00
IUUC-Opr-070988	Ochotona princeps	72.61	6.00e-68	251.00
IUUC-Ont-072039	Oreochromis niloticus	33.75	3.00e-47	182.00
IUUC-Oan-073740	Ornithorhynchus anatinus	58.06	2.00e-77	281.00
IUUC-Ocu-074498	Oryctolagus cuniculus	75.60	7.00e-156	543.00
IUUC-Ola-086753	Oryzias latipes	35.03	1.00e-46	180.00
IUUC-Oga-088497	Otolemur garnettii	79.39	8.00e-172	596.00
IUUC-Oar-089505	Ovis aries	75.86	4.00e-148	517.00
IUUC-Ptr-091656	Pan troglodytes	98.92	0.00e+00	766.00
IUUC-Pan-092498	Papio anubis	92.51	0.00e+00	722.00
IUUC-Psi-093409	Pelodiscus sinensis	55.71	7.00e-112	397.00
IUUC-Pfo-096507	Poecilia formosa	34.29	2.00e-47	183.00
IUUC-Pab-097828	Pongo abelii	94.43	0.00e+00	635.00
IUUC-Pca-100299	Procavia capensis	75.93	1.00e-105	376.00
IUUC-Pva-102972	Pteropus vampyrus	77.24	6.00e-164	570.00
IUUC-Rno-105738	Rattus norvegicus	70.62	9.00e-154	536.00
IUUC-Sar-112983	Sorex araneus	73.43	1.00e-119	422.00
IUUC-Ssc-116049	Sus scrofa	77.12	1.00e-152	532.00
IUUC-Tgu-117115	Taeniopygia guttata	56.01	5.00e-103	367.00
IUUC-Tru-118022	Takifugu rubripes	31.76	8.00e-41	160.00
IUUC-Tsy-118986	Tarsius syrichta	61.61	6.00e-63	234.00
IUUC-Tni-120306	Tetraodon nigroviridis	31.65	9.00e-39	154.00
IUUC-Tbe-127768	Tupaia belangeri	68.79	8.00e-116	410.00
IUUC-Ttr-128686	Tursiops truncatus	75.00	2.00e-152	531.00
IUUC-Xtr-132032	Xenopus tropicalis	42.77	6.00e-70	257.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence